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Bryan Maloney

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Publication Info
Gene × environment interaction by a longitudinal epigenome-wide association study (LEWAS) overcomes limitations of genome-wide association study (GWAS). Lahiri DK, Maloney B Epigenomics. 4(6):685-99. doi: 10.2217/epi.12.60. December 2012. View on PubMed.
Structural and functional characterization of H2 haplotype MAPT promoter: unique neurospecific domains and a hypoxia-inducible element would enhance rationally targeted tauopathy research for Alzheimer's disease. Maloney B, Lahiri DK Gene. 501(1):63-78. doi: 10.1016/j.gene.2012.01.049. June 10, 2012. View on PubMed.
Applying epigenetics to Alzheimer's disease via the latent early-life associated regulation (LEARn) model. Maloney B, Sambamurti K, Zawia N, Lahiri DK Curr Alzheimer Res. 9(5):589-99. June 2012. View on PubMed.
Do epigenetic pathways initiate late onset Alzheimer disease (LOAD): towards a new paradigm. Bihaqi SW, Schumacher A, Maloney B, Lahiri DK, Zawia NH Curr Alzheimer Res. 9(5):574-88. June 2012. View on PubMed.
The "LEARn" (latent early-life associated regulation) model: an epigenetic pathway linking metabolic and cognitive disorders. Lahiri DK, Maloney B J Alzheimers Dis. 30 Suppl 2:S15-30. doi: 10.3233/JAD-2012-120373. 2012. View on PubMed.
Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis. Bailey JA, Maloney B, Ge YW, Lahiri DK Gene. 488(1-2):13-22. doi: 10.1016/j.gene.2011.06.017. November 15, 2011. View on PubMed.
The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motif. Maloney B, Lahiri DK Gene. 488(1-2):1-12. doi: 10.1016/j.gene.2011.06.004. November 15, 2011. View on PubMed.
Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links. Sokol DK, Maloney B, Long JM, Ray B, Lahiri DK Neurology. 76(15):1344-52. doi: 10.1212/WNL.0b013e3182166dc7. April 12, 2011. View on PubMed.
Beyond the signaling effect role of amyloid-ß42 on the processing of APP, and its clinical implications. Lahiri DK, Maloney B Exp Neurol. 225(1):51-4. doi: 10.1016/j.expneurol.2010.04.018. September 2010. View on PubMed.
The "LEARn" (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer's disease, and proposes remedial steps. Lahiri DK, Maloney B Exp Gerontol. 45(4):291-6. doi: 10.1016/j.exger.2010.01.001. April 2010. View on PubMed.
Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions. Maloney B, Ge YW, Petersen RC, Hardy J, Rogers JT, Pérez-Tur J, Lahiri DK Am J Med Genet B Neuropsychiatr Genet. 153B(1):185-201. doi: 10.1002/ajmg.b.30973. January 5, 2010. View on PubMed.
The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases. Lahiri DK, Maloney B, Zawia NH Mol Psychiatry. 14(11):992-1003. doi: 10.1038/mp.2009.82. November 2009. View on PubMed.
Development and validation of the high-quality 'rapid method for swab' to genotype the HTTLPR serotonin transporter (SLC6A4) promoter polymorphism. Maloney B, Ray B, Hayden EP, Nurnberger JI Jr, Lahiri DK Psychiatr Genet. 19(2):72-82. doi: 10.1097/YPG.0b013e3283208091. April 2009. View on PubMed.
Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice. Dosunmu R, Wu J, Adwan L, Maloney B, Basha MR, McPherson CA, Harry GJ, Rice DC, Zawia NH, Lahiri DK J Alzheimers Dis. 18(1):211-30. doi: 10.3233/JAD-2009-1138. 2009. View on PubMed.
Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model. Lahiri DK, Zawia NH, Greig NH, Sambamurti K, Maloney B Biogerontology. 9(6):375-9. doi: 10.1007/s10522-008-9162-6. December 2008. View on PubMed.
Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism. Hayden EP, Dougherty LR, Maloney B, Olino TM, Sheikh H, Durbin CE, Nurnberger JI Jr, Lahiri DK, Klein DN J Affect Disord. 107(1-3):227-30. doi: 10.1016/j.jad.2007.07.028. April 2008. View on PubMed.
Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marié I, Maurin T and 9 others Neuron. 57(5):680-90. doi: 10.1016/j.neuron.2008.02.024. March 13, 2008. View on PubMed.
Co-localization and distribution of cerebral APP and SP1 and its relationship to amyloidogenesis. Brock B, Basha R, DiPalma K, Anderson A, Harry GJ, Rice DC, Maloney B, Lahiri DK, Zawia NH J Alzheimers Dis. 13(1):71-80. February 2008. View on PubMed.
Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. Wu J, Basha MR, Brock B, Cox DP, Cardozo-Pelaez F, McPherson CA, Harry J and 5 others J Neurosci. 28(1):3-9. doi: 10.1523/JNEUROSCI.4405-07.2008. January 2, 2008. View on PubMed.
Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer's disease. Maloney B, Ge YW, Alley GM, Lahiri DK J Neurochem. 103(3):1237-57. doi: 10.1111/j.1471-4159.2007.04831.x. November 2007. View on PubMed.
Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism: a multimethod association study. Hayden EP, Dougherty LR, Maloney B, Emily Durbin C, Olino TM, Nurnberger JI Jr, Lahiri DK, Klein DN Psychiatr Genet. 17(3):135-42. doi: 10.1097/YPG.0b013e3280147847. June 2007. View on PubMed.
How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the "LEARn" model (latent early-life associated regulation) may explain the triggering of AD. Lahiri DK, Maloney B, Basha MR, Ge YW, Zawia NH Curr Alzheimer Res. 4(2):219-28. April 2007. View on PubMed.
The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. Lahiri DK, Chen D, Maloney B, Holloway HW, Yu QS, Utsuki T, Giordano T, Sambamurti K, Greig NH J Pharmacol Exp Ther. 320(1):386-96. doi: 10.1124/jpet.106.112102. January 2007. View on PubMed.
Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors. Lahiri DK, Ge YW, Rogers JT, Sambamurti K, Greig NH, Maloney B Curr Alzheimer Res. 3(5):475-83. December 2006. View on PubMed.
High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression. Sokol DK, Chen D, Farlow MR, Dunn DW, Maloney B, Zimmer JA, Lahiri DK J Child Neurol. 21(6):444-9. doi: 10.1177/08830738060210062201. June 2006. View on PubMed.
Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain. Bolin CM, Basha R, Cox D, Zawia NH, Maloney B, Lahiri DK, Cardozo-Pelaez F FASEB J. 20(6):788-90. doi: 10.1096/fj.05-5091fje. April 2006. View on PubMed.
Characterization of the human beta-secretase 2 (BACE2) 5'-flanking region: identification of a 268-bp region as the basal BACE2 promoter. Maloney B, Ge YW, Greig NH, Lahiri DK J Mol Neurosci. 29(1):81-99. doi: 10.1385/JMN:29:1:81. 2006. View on PubMed.
Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells. Lahiri DK, Maloney B, Ge YW J Mol Neurosci. 29(1):65-80. doi: 10.1385/JMN:29:1:65. 2006. View on PubMed.
BACE1 gene promoter is differentially regulated: detection of a novel promoter region for its cell type-specific regulation. Lahiri DK, Maloney B, Ge YW J Mol Neurosci. 28(2):193-210. doi: 10.1385/JMN:28:2:193. 2006. View on PubMed.
Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease. Lahiri DK, Ge YW, Maloney B, Wavrant-De Vrièze F, Hardy J Neurobiol Aging. 26(10):1329-41. doi: 10.1016/j.neurobiolaging.2004.11.005. December 2005. View on PubMed.
NF-(kappa)B mediates amyloid beta peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells. Du Y, Chen X, Wei X, Bales KR, Berg DT, Paul SM, Farlow MR, Maloney B, Ge YW, Lahiri DK Brain Res Mol Brain Res. 136(1-2):177-88. doi: 10.1016/j.molbrainres.2005.02.001. May 20, 2005. View on PubMed.
Characterization of the APP proximal promoter and 5'-untranslated regions: identification of cell type-specific domains and implications in APP gene expression and Alzheimer's disease. Lahiri DK, Ge YW, Maloney B FASEB J. 19(6):653-5. doi: 10.1096/fj.04-2900fje. April 2005. View on PubMed.
Challenges in creating a vaccine to prevent hepatitis E. Maloney BJ, Takeda N, Suzaki Y, Ami Y, Li TC, Miyamura T, Arntzen CJ, Mason HS Vaccine. 23(15):1870-4. doi: 10.1016/j.vaccine.2004.11.020. March 7, 2005. View on PubMed.
Virus-like particle expression and assembly in plants: hepatitis B and Norwalk viruses. Huang Z, Elkin G, Maloney BJ, Beuhner N, Arntzen CJ, Thanavala Y, Mason HS Vaccine. 23(15):1851-8. doi: 10.1016/j.vaccine.2004.11.017. March 7, 2005. View on PubMed.
Mechanism of promoter activity of the beta-amyloid precursor protein gene in different cell lines: identification of a specific 30 bp fragment in the proximal promoter region. Ge YW, Ghosh C, Song W, Maloney B, Lahiri DK J Neurochem. 90(6):1432-44. doi: 10.1111/j.1471-4159.2004.02608.x. September 2004. View on PubMed.
Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease. Maloney B, Ge YW, Greig N, Lahiri DK FASEB J. 18(11):1288-90. doi: 10.1096/fj.03-1703fje. August 2004. View on PubMed.
Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression. Ge YW, Maloney B, Sambamurti K, Lahiri DK FASEB J. 18(9):1037-9. doi: 10.1096/fj.03-1379fje. June 2004. View on PubMed.
Gene structure and organization of the human beta-secretase (BACE) promoter. Sambamurti K, Kinsey R, Maloney B, Ge YW, Lahiri DK FASEB J. 18(9):1034-6. doi: 10.1096/fj.03-1378fje. June 2004. View on PubMed.
Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene. Bellingham SA, Lahiri DK, Maloney B, La Fontaine S, Multhaup G, Camakaris J J Biol Chem. 279(19):20378-86. doi: 10.1074/jbc.M400805200. May 7, 2004. View on PubMed.
Construction of recombinant avian infectious laryngotracheitis virus expressing the beta-galactosidase gene and DNA sequencing of the insertion region. Guo P, Scholz E, Maloney B, Welniak E Virology. 202(2):771-81. doi: 10.1006/viro.1994.1399. August 1, 1994. View on PubMed.
Assembly pathway of avian infectious laryngotracheitis virus. Guo P, Scholz E, Turek J, Nodgreen R, Maloney B Am J Vet Res. 54(12):2031-9. December 1993. View on PubMed.
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