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Dennis Cvitkovitch

Associate Dean Research - Dental Research Institute

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Associate Dean Research - Dental Research Institute University of Toronto

The Dental Research Institute is located in The Faculty of Dentistry. We have a robust research that is both grant and private contract funded in a diverse are of disciplines in both basic and clinical science. We also offer core facilities for outside users that include, histology, microscopy (SEM, Laser dissection, fluorescent, CLSM), Micro CT, mechanical testing, microbiological analyses: http://www.utoronto.ca/dentistry/facultyresearch/dri.html

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Jun 2008 - Present
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Publication Info
CinA is regulated via ComX to modulate genetic transformation and cell viability in Streptococcus mutans. Mair RW, Senadheera DB, Cvitkovitch DG FEMS Microbiol Lett. 331(1):44-52. doi: 10.1111/j.1574-6968.2012.02550.x. June 2012. View on PubMed.
Regulation of bacteriocin production and cell death by the VicRK signaling system in Streptococcus mutans. Senadheera DB, Cordova M, Ayala EA, Chávez de Paz LE, Singh K, Downey JS, Svensäter G, Goodman SD, Cvitkovitch DG J Bacteriol. 194(6):1307-16. doi: 10.1128/JB.06071-11. March 2012. View on PubMed.
TcyR regulates L-cystine uptake via the TcyABC transporter in Streptococcus mutans. Kim J, Senadheera DB, Lévesque CM, Cvitkovitch DG FEMS Microbiol Lett. 328(2):114-21. doi: 10.1111/j.1574-6968.2011.02492.x. March 2012. View on PubMed.
Oligomerization of the response regulator ComE from Streptococcus mutans is affected by phosphorylation. Hung DC, Downey JS, Kreth J, Qi F, Shi W, Cvitkovitch DG, Goodman SD J Bacteriol. 194(5):1127-35. doi: 10.1128/JB.06565-11. March 2012. View on PubMed.
Regulation of the competence pathway as a novel role associated with a streptococcal bacteriocin. Dufour D, Cordova M, Cvitkovitch DG, Lévesque CM J Bacteriol. 193(23):6552-9. doi: 10.1128/JB.05968-11. December 2011. View on PubMed.
Bacterial biogeography of the human digestive tract. Stearns JC, Lynch MD, Senadheera DB, Tenenbaum HC, Goldberg MB, Cvitkovitch DG, Croitoru K, Moreno-Hagelsieb G, Neufeld JD Sci Rep. 1:170. doi: 10.1038/srep00170. November 25, 2011. View on PubMed.
Characterization of DNA binding sites of the ComE response regulator from Streptococcus mutans. Hung DC, Downey JS, Ayala EA, Kreth J, Mair R, Senadheera DB, Qi F, Cvitkovitch DG, Shi W, Goodman SD J Bacteriol. 193(14):3642-52. doi: 10.1128/JB.00155-11. May 20, 2011. View on PubMed.
Biodegradation of resin-dentin interfaces increases bacterial microleakage. Kermanshahi S, Santerre JP, Cvitkovitch DG, Finer Y J Dent Res. 89(9):996-1001. doi: 10.1177/0022034510372885. May 26, 2010. View on PubMed.
Acid tolerance mechanisms utilized by Streptococcus mutans. Matsui R, Cvitkovitch D Future Microbiol. 5(3):403-17. doi: 10.2217/fmb.09.129. March 2010. View on PubMed.
Characterization of a glutamate transporter operon, glnQHMP, in Streptococcus mutans and its role in acid tolerance. Krastel K, Senadheera DB, Mair R, Downey JS, Goodman SD, Cvitkovitch DG J Bacteriol. 192(4):984-93. doi: 10.1128/JB.01169-09. December 18, 2009. View on PubMed.
Atypical roles for Campylobacter jejuni amino acid ATP binding cassette transporter components PaqP and PaqQ in bacterial stress tolerance and pathogen-host cell dynamics. Lin AE, Krastel K, Hobb RI, Thompson SA, Cvitkovitch DG, Gaynor EC Infect Immun. 77(11):4912-24. doi: 10.1128/IAI.00571-08. August 24, 2009. View on PubMed.
Cell death in Streptococcus mutans biofilms: a link between CSP and extracellular DNA. Perry JA, Cvitkovitch DG, Lévesque CM FEMS Microbiol Lett. 299(2):261-6. doi: 10.1111/j.1574-6968.2009.01758.x. August 18, 2009. View on PubMed.
Inactivation of VicK affects acid production and acid survival of Streptococcus mutans. Senadheera D, Krastel K, Mair R, Persadmehr A, Abranches J, Burne RA, Cvitkovitch DG J Bacteriol. 191(20):6415-24. doi: 10.1128/JB.00793-09. August 14, 2009. View on PubMed.
Acid-stress-induced changes in enterohaemorrhagic Escherichia coli O157 : H7 virulence. House B, Kus JV, Prayitno N, Mair R, Que L, Chingcuanco F, Gannon V, Cvitkovitch DG, Barnett Foster D Microbiology. 155(Pt 9):2907-18. doi: 10.1099/mic.0.025171-0. June 4, 2009. View on PubMed.
Peptide alarmone signalling triggers an auto-active bacteriocin necessary for genetic competence. Perry JA, Jones MB, Peterson SN, Cvitkovitch DG, Lévesque CM Mol Microbiol. 72(4):905-17. doi: 10.1111/j.1365-2958.2009.06693.x. April 14, 2009. View on PubMed.
The LiaFSR system regulates the cell envelope stress response in Streptococcus mutans. Suntharalingam P, Senadheera MD, Mair RW, Lévesque CM, Cvitkovitch DG J Bacteriol. 191(9):2973-84. doi: 10.1128/JB.01563-08. February 27, 2009. View on PubMed.
Composite resin degradation products from BisGMA monomer modulate the expression of genes associated with biofilm formation and other virulence factors in Streptococcus mutans. Singh J, Khalichi P, Cvitkovitch DG, Santerre JP J Biomed Mater Res A. 88(2):551-60. doi: 10.1002/jbm.a.31879. February 2009. View on PubMed.
Simultaneous interferometric measurement of corrosive or demineralizing bacteria and their mineral interfaces. Waters MS, El-Naggar MY, Hsu L, Sturm CA, Luttge A, Udwadia FE, Cvitkovitch DG, Goodman SD, Nealson KH Appl Environ Microbiol. 75(5):1445-9. doi: 10.1128/AEM.02039-08. January 5, 2009. View on PubMed.
The involvement of the pyruvate dehydrogenase E1alpha subunit, in Streptococcus mutans acid tolerance. Korithoski B, Lévesque CM, Cvitkovitch DG FEMS Microbiol Lett. 289(1):13-9. doi: 10.1111/j.1574-6968.2008.01351.x. December 2008. View on PubMed.
The influence of triethylene glycol derived from dental composite resins on the regulation of Streptococcus mutans gene expression. Khalichi P, Singh J, Cvitkovitch DG, Santerre JP Biomaterials. 30(4):452-9. doi: 10.1016/j.biomaterials.2008.09.053. November 5, 2008. View on PubMed.
Involvement of Streptococcus mutans regulator RR11 in oxidative stress response during biofilm growth and in the development of genetic competence. Perry JA, Lévesque CM, Suntharaligam P, Mair RW, Bu M, Cline RT, Peterson SN, Cvitkovitch DG Lett Appl Microbiol. 47(5):439-44. doi: 10.1111/j.1472-765X.2008.02455.x. November 2008. View on PubMed.
Regulation of sagA, siaA and scpC by SilCR, a putative signaling peptide of Streptococcus pyogenes. Salim KY, de Azavedo JC, Bast DJ, Cvitkovitch DG FEMS Microbiol Lett. 289(2):119-25. doi: 10.1111/j.1574-6968.2008.01375.x. October 29, 2008. View on PubMed.
Modification of Pseudomonas aeruginosa Pa5196 type IV Pilins at multiple sites with D-Araf by a novel GT-C family Arabinosyltransferase, TfpW. Kus JV, Kelly J, Tessier L, Harvey H, Cvitkovitch DG, Burrows LL J Bacteriol. 190(22):7464-78. doi: 10.1128/JB.01075-08. September 19, 2008. View on PubMed.
Novel proteins that modulate type IV pilus retraction dynamics in Pseudomonas aeruginosa. Asikyan ML, Kus JV, Burrows LL J Bacteriol. 190(21):7022-34. doi: 10.1128/JB.00938-08. September 5, 2008. View on PubMed.
In search of the microbe/mineral interface: quantitative analysis of bacteria on metal surfaces using vertical scanning interferometry. Waters MS, Sturm CA, El-Naggar MY, Luttge A, Udwadia FE, Cvitkovitch DG, Goodman SD, Nealson KH Geobiology. 6(3):254-62. doi: 10.1111/j.1472-4669.2008.00161.x. May 6, 2008. View on PubMed.
Antibiofilm activity of sodium bicarbonate, sodium metaperiodate and SDS combination against dental unit waterline-associated bacteria and yeast. Gawande PV, LoVetri K, Yakandawala N, Romeo T, Zhanel GG, Cvitkovitch DG, Madhyastha S J Appl Microbiol. 105(4):986-92. doi: 10.1111/j.1365-2672.2008.03823.x. April 16, 2008. View on PubMed.
Quorum sensing and biofilm formation by Streptococcus mutans. Senadheera D, Cvitkovitch DG Adv Exp Med Biol. 631:178-88. doi: 10.1007/978-0-387-78885-2_12. 2008. View on PubMed.
Autoinducer-2-regulated genes in Streptococcus mutans UA159 and global metabolic effect of the luxS mutation. Sztajer H, Lemme A, Vilchez R, Schulz S, Geffers R, Yip CY, Levesque CM, Cvitkovitch DG, Wagner-Döbler I J Bacteriol. 190(1):401-15. doi: 10.1128/JB.01086-07. November 2, 2007. View on PubMed.
Systemic inactivation and phenotypic characterization of two-component systems in expression of Streptococcus mutans virulence properties. Lévesque CM, Mair RW, Perry JA, Lau PC, Li YH, Cvitkovitch DG Lett Appl Microbiol. 45(4):398-404. doi: 10.1111/j.1472-765X.2007.02203.x. October 2007. View on PubMed.
Involvement of the detoxifying enzyme lactoylglutathione lyase in Streptococcus mutans aciduricity. Korithoski B, Lévesque CM, Cvitkovitch DG J Bacteriol. 189(21):7586-92. doi: 10.1128/JB.00754-07. August 24, 2007. View on PubMed.
Role for sagA and siaA in quorum sensing and iron regulation in Streptococcus pyogenes. Salim KY, de Azavedo JC, Bast DJ, Cvitkovitch DG Infect Immun. 75(10):5011-7. doi: 10.1128/IAI.01824-06. July 16, 2007. View on PubMed.
The response regulator ComE in Streptococcus mutans functions both as a transcription activator of mutacin production and repressor of CSP biosynthesis. Kreth J, Hung DC, Merritt J, Perry J, Zhu L, Goodman SD, Cvitkovitch DG, Shi W, Qi F Microbiology. 153(Pt 6):1799-807. doi: 10.1099/mic.0.2007/005975-0. June 2007. View on PubMed.
Modification of an effector strain for replacement therapy of dental caries to enable clinical safety trials. Hillman JD, Mo J, McDonell E, Cvitkovitch D, Hillman CH J Appl Microbiol. 102(5):1209-19. doi: 10.1111/j.1365-2672.2007.03316.x. May 2007. View on PubMed.
The Streptococcus mutans vicX gene product modulates gtfB/C expression, biofilm formation, genetic competence, and oxidative stress tolerance. Senadheera MD, Lee AW, Hung DC, Spatafora GA, Goodman SD, Cvitkovitch DG J Bacteriol. 189(4):1451-8. doi: 10.1128/JB.01161-06. November 17, 2006. View on PubMed.
Glycosylation of Pseudomonas aeruginosa strain Pa5196 type IV pilins with mycobacterium-like alpha-1,5-linked d-Araf oligosaccharides. Voisin S, Kus JV, Houliston S, St-Michael F, Watson D, Cvitkovitch DG, Kelly J, Brisson JR, Burrows LL J Bacteriol. 189(1):151-9. doi: 10.1128/JB.01224-06. November 3, 2006. View on PubMed.
Streptococcal viability and diminished stress tolerance in mutants lacking the signal recognition particle pathway or YidC2. Hasona A, Crowley PJ, Levesque CM, Mair RW, Cvitkovitch DG, Bleiweis AS, Brady LJ Proc Natl Acad Sci U S A. 102(48):17466-71. doi: 10.1073/pnas.0508778102. November 29, 2005. View on PubMed.
Peptide pheromone induced cell death of Streptococcus mutans. Qi F, Kreth J, Lévesque CM, Kay O, Mair RW, Shi W, Cvitkovitch DG, Goodman SD FEMS Microbiol Lett. 251(2):321-6. doi: 10.1016/j.femsle.2005.08.018. October 15, 2005. View on PubMed.
Identification of group A Streptococcus antigenic determinants upregulated in vivo. Salim KY, Cvitkovitch DG, Chang P, Bast DJ, Handfield M, Hillman JD, de Azavedo JC Infect Immun. 73(9):6026-38. doi: 10.1128/IAI.73.9.6026-6038.2005. September 2005. View on PubMed.
Transport and metabolism of citrate by Streptococcus mutans. Korithoski B, Krastel K, Cvitkovitch DG J Bacteriol. 187(13):4451-6. doi: 10.1128/JB.187.13.4451-4456.2005. July 2005. View on PubMed.
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development. Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG J Bacteriol. 187(12):4064-76. doi: 10.1128/JB.187.12.4064-4076.2005. June 2005. View on PubMed.
Involvement of sortase anchoring of cell wall proteins in biofilm formation by Streptococcus mutans. Lévesque CM, Voronejskaia E, Huang YC, Mair RW, Ellen RP, Cvitkovitch DG Infect Immun. 73(6):3773-7. doi: 10.1128/IAI.73.6.3773-3777.2005. June 2005. View on PubMed.
Quorum sensing in streptococcal biofilm formation. Suntharalingam P, Cvitkovitch DG Trends Microbiol. 13(1):3-6. doi: 10.1016/j.tim.2004.11.009. January 2005. View on PubMed.
Trigger factor in Streptococcus mutans is involved in stress tolerance, competence development, and biofilm formation. Wen ZT, Suntharaligham P, Cvitkovitch DG, Burne RA Infect Immun. 73(1):219-25. doi: 10.1128/IAI.73.1.219-225.2005. January 2005. View on PubMed.
Effect of composite resin biodegradation products on oral streptococcal growth. Khalichi P, Cvitkovitch DG, Santerre JP Biomaterials. 25(24):5467-72. doi: 10.1016/j.biomaterials.2003.12.056. November 2004. View on PubMed.
ComX activity of Streptococcus mutans growing in biofilms. Aspiras MB, Ellen RP, Cvitkovitch DG FEMS Microbiol Lett. 238(1):167-74. doi: 10.1016/j.femsle.2004.07.032. September 1, 2004. View on PubMed.
Significant differences in type IV pilin allele distribution among Pseudomonas aeruginosa isolates from cystic fibrosis (CF) versus non-CF patients. Kus JV, Tullis E, Cvitkovitch DG, Burrows LL Microbiology. 150(Pt 5):1315-26. doi: 10.1099/mic.0.26822-0. May 2004. View on PubMed.
Esp-independent biofilm formation by Enterococcus faecalis. Kristich CJ, Li YH, Cvitkovitch DG, Dunny GM J Bacteriol. 186(1):154-63. January 2004. View on PubMed.
Quorum sensing and biofilm formation in Streptococcal infections. Cvitkovitch DG, Li YH, Ellen RP J Clin Invest. 112(11):1626-32. doi: 10.1172/JCI20430. December 2003. View on PubMed.
Effect of an orphan response regulator on Streptococcus mutans sucrose-dependent adherence and cariogenesis. Idone V, Brendtro S, Gillespie R, Kocaj S, Peterson E, Rendi M, Warren W and 4 others Infect Immun. 71(8):4351-60. August 2003. View on PubMed.
Novel two-component regulatory system involved in biofilm formation and acid resistance in Streptococcus mutans. Li YH, Lau PC, Tang N, Svensäter G, Ellen RP, Cvitkovitch DG J Bacteriol. 184(22):6333-42. November 2002. View on PubMed.
A quorum-sensing signaling system essential for genetic competence in Streptococcus mutans is involved in biofilm formation. Li YH, Tang N, Aspiras MB, Lau PC, Lee JH, Ellen RP, Cvitkovitch DG J Bacteriol. 184(10):2699-708. May 2002. View on PubMed.
PCR ligation mutagenesis in transformable streptococci: application and efficiency. Lau PC, Sung CK, Lee JH, Morrison DA, Cvitkovitch DG J Microbiol Methods. 49(2):193-205. April 2002. View on PubMed.
Cell density modulates acid adaptation in Streptococcus mutans: implications for survival in biofilms. Li YH, Hanna MN, Svensäter G, Ellen RP, Cvitkovitch DG J Bacteriol. 183(23):6875-84. doi: 10.1128/JB.183.23.6875-6884.2001. December 2001. View on PubMed.
uvrA is an acid-inducible gene involved in the adaptive response to low pH in Streptococcus mutans. Hanna MN, Ferguson RJ, Li YH, Cvitkovitch DG J Bacteriol. 183(20):5964-73. doi: 10.1128/JB.183.20.5964-5973.2001. October 2001. View on PubMed.
Natural genetic transformation of Streptococcus mutans growing in biofilms. Li YH, Lau PC, Lee JH, Ellen RP, Cvitkovitch DG J Bacteriol. 183(3):897-908. doi: 10.1128/JB.183.3.897-908.2001. February 2001. View on PubMed.
Genetic competence and transformation in oral streptococci. Cvitkovitch DG Crit Rev Oral Biol Med. 12(3):217-43. 2001. View on PubMed.
Resistance of a novel root canal sealer to bacterial ingress in vitro. Padachey N, Patel V, Santerre P, Cvitkovitch D, Lawrence HP, Friedman S J Endod. 26(11):656-9. doi: 10.1097/00004770-200011000-00006. November 2000. View on PubMed.
Defects in D-alanyl-lipoteichoic acid synthesis in Streptococcus mutans results in acid sensitivity. Boyd DA, Cvitkovitch DG, Bleiweis AS, Kiriukhin MY, Debabov DV, Neuhaus FC, Hamilton IR J Bacteriol. 182(21):6055-65. November 2000. View on PubMed.
A novel beta-glucoside-specific PTS locus from Streptococcus mutans that is not inhibited by glucose. Cote CK, Cvitkovitch D, Bleiweis AS, Honeyman AL Microbiology. 146 ( Pt 7):1555-63. doi: 10.1099/00221287-146-7-1555. July 2000. View on PubMed.
Tn917-lac mutagenesis of Streptococcus mutans to identify environmentally regulated genes. Cvitkovitch DG, Gutierrez JA, Behari J, Youngman PJ, Wetz JE, Crowley PJ, Hillman JD, Brady LJ, Bleiweis AS FEMS Microbiol Lett. 182(1):149-54. January 1, 2000. View on PubMed.
Streptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit of the signal recognition particle, is involved in resistance to acid stress. Gutierrez JA, Crowley PJ, Cvitkovitch DG, Brady LJ, Hamilton IR, Hillman JD, Bleiweis AS Microbiology. 145 ( Pt 2):357-66. doi: 10.1099/13500872-145-2-357. February 1999. View on PubMed.
Deletion of the central proline-rich repeat domain results in altered antigenicity and lack of surface expression of the Streptococcus mutans P1 adhesin molecule. Brady LJ, Cvitkovitch DG, Geric CM, Addison MN, Joyce JC, Crowley PJ, Bleiweis AS Infect Immun. 66(9):4274-82. September 1998. View on PubMed.
Genetic and biochemical analysis of mutacin 1140, a lantibiotic from Streptococcus mutans. Hillman JD, Novák J, Sagura E, Gutierrez JA, Brooks TA, Crowley PJ, Hess M and 4 others Infect Immun. 66(6):2743-9. June 1998. View on PubMed.
Acid tolerance response and survival by oral bacteria. Svensäter G, Larsson UB, Greif EC, Cvitkovitch DG, Hamilton IR Oral Microbiol Immunol. 12(5):266-73. October 1997. View on PubMed.
Role of the citrate pathway in glutamate biosynthesis by Streptococcus mutans. Cvitkovitch DG, Gutierrez JA, Bleiweis AS J Bacteriol. 179(3):650-5. February 1997. View on PubMed.
Regulation of sugar transport via the multiple sugar metabolism operon of Streptococcus mutans by the phosphoenolpyruvate phosphotransferase system. Cvitkovitch DG, Boyd DA, Hamilton IR J Bacteriol. 177(19):5704-6. October 1995. View on PubMed.
Sequence, expression, and function of the gene for the nonphosphorylating, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase of Streptococcus mutans. Boyd DA, Cvitkovitch DG, Hamilton IR J Bacteriol. 177(10):2622-7. May 1995. View on PubMed.
Glucose transport by a mutant of Streptococcus mutans unable to accumulate sugars via the phosphoenolpyruvate phosphotransferase system. Cvitkovitch DG, Boyd DA, Thevenot T, Hamilton IR J Bacteriol. 177(9):2251-8. May 1995. View on PubMed.
Regulation of sugar uptake via the multiple sugar metabolism operon by the phosphoenolpyruvate-dependent sugar phosphotransferase transport system of Streptococcus mutans. Cvitkovitch DG, Boyd DA, Hamilton IR Dev Biol Stand. 85:351-6. 1995. View on PubMed.
Biochemical change exhibited by oral streptococci resulting from laboratory subculturing. Cvitkovitch DG, Hamilton IR Oral Microbiol Immunol. 9(4):209-17. August 1994. View on PubMed.
Sequence and expression of the genes for HPr (ptsH) and enzyme I (ptsI) of the phosphoenolpyruvate-dependent phosphotransferase transport system from Streptococcus mutans. Boyd DA, Cvitkovitch DG, Hamilton IR Infect Immun. 62(4):1156-65. April 1994. View on PubMed.
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