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Ethan Perlstein

Founder & CEO - Perlstein Lab, PBC View Biosketch →

Please see CV below.

Position - Company  
Consultant - Microryza Feb 2013 - Aug 2013
Lewis-Sigler Fellow - Princeton University Sep 2007 - Dec 2012
Postdoctoral Fellow - Broad Institute Genomic Services May 2006 - Aug 2007
Founder & CEO - Perlstein Lab, PBC

We are a mission-driven biotech startup focused on precision drug discovery for rare/orphan diseases.

Show details
Dec 2013 - Present
Degree - University  
Doctor of Philosophy (Ph.D.), Molecular and Cellular Biology - Harvard University 2001 - 2006
BA, History-Sociology - Columbia University 1997 - 2001
Publication Info
Accumulation of an antidepressant in vesiculogenic membranes of yeast cells triggers autophagy. Chen J, Korostyshevsky D, Lee S, Perlstein EO PLoS One. 7(4):e34024. doi: 10.1371/journal.pone.0034024. April 18, 2012. View on PubMed.
The antidepressant sertraline targets intracellular vesiculogenic membranes in yeast. Rainey MM, Korostyshevsky D, Lee S, Perlstein EO Genetics. 185(4):1221-33. doi: 10.1534/genetics.110.117846. May 10, 2010. View on PubMed.
Harnessing gene expression to identify the genetic basis of drug resistance. Chen BJ, Causton HC, Mancenido D, Goddard NL, Perlstein EO, Pe'er D Mol Syst Biol. 5:310. doi: 10.1038/msb.2009.69. October 13, 2009. View on PubMed.
Using expression and genotype to predict drug response in yeast. Ruderfer DM, Roberts DC, Schreiber SL, Perlstein EO, Kruglyak L PLoS One. 4(9):e6907. doi: 10.1371/journal.pone.0006907. September 4, 2009. View on PubMed.
Amino acid metabolic origin as an evolutionary influence on protein sequence in yeast. de Bivort BL, Perlstein EO, Kunes S, Schreiber SL J Mol Evol. 68(5):490-7. doi: 10.1007/s00239-009-9218-5. May 2009. View on PubMed.
Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages. Floto RA, Sarkar S, Perlstein EO, Kampmann B, Schreiber SL, Rubinsztein DC Autophagy. 3(6):620-2. December 2007. View on PubMed.
Evolutionarily conserved optimization of amino acid biosynthesis. Perlstein EO, de Bivort BL, Kunes S, Schreiber SL J Mol Evol. 65(2):186-96. doi: 10.1007/s00239-007-0013-x. August 2007. View on PubMed.
Quantifying fitness distributions and phenotypic relationships in recombinant yeast populations. Perlstein EO, Deeds EJ, Ashenberg O, Shakhnovich EI, Schreiber SL Proc Natl Acad Sci U S A. 104(25):10553-8. doi: 10.1073/pnas.0704037104. June 19, 2007. View on PubMed.
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA and 4 others Nat Chem Biol. 3(6):331-8. doi: 10.1038/nchembio883. June 2007. View on PubMed.
Genetic basis of individual differences in the response to small-molecule drugs in yeast. Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, Kruglyak L Nat Genet. 39(4):496-502. doi: 10.1038/ng1991. April 2007. View on PubMed.
Revealing complex traits with small molecules and naturally recombinant yeast strains. Perlstein EO, Ruderfer DM, Ramachandran G, Haggarty SJ, Kruglyak L, Schreiber SL Chem Biol. 13(3):319-27. doi: 10.1016/j.chembiol.2006.01.010. March 2006. View on PubMed.
Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway. Butcher RA, Bhullar BS, Perlstein EO, Marsischky G, LaBaer J, Schreiber SL Nat Chem Biol. 2(2):103-9. doi: 10.1038/nchembio762. February 2006. View on PubMed.
A library of spirooxindoles based on a stereoselective three-component coupling reaction. Lo MM, Neumann CS, Nagayama S, Perlstein EO, Schreiber SL J Am Chem Soc. 126(49):16077-86. doi: 10.1021/ja045089d. December 15, 2004. View on PubMed.
Global nucleosome occupancy in yeast. Bernstein BE, Liu CL, Humphrey EL, Perlstein EO, Schreiber SL Genome Biol. 5(9):R62. doi: 10.1186/gb-2004-5-9-r62. August 20, 2004. View on PubMed.
From Crystal Davey (Mutation Generation and Detection Facility) on 2014-05-29 08:49:52 -1000 Ethan and his entire team at Perlstein Labs were great to work with. Read more
From Ajay Bhargava (Shakti BioResearch LLC) on 2012-08-22 00:47:07 -1000 It was a pleasure working with Dr. Ethan Perlstein. He was approachable, communicated well all al... Read more