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Trevor Mckee

Computational Image Analysis Manager -

Bioengineer with extensive experience in the application of imaging techniques to quantitative measurement of transport processes, drug and gene delivery, and tumor microenvironmental parameters within a variety of mouse models of cancer. Track record of successful industry-partnered research collaborations during my PhD and postdoctoral work, delivering successfully on quarterly goals and delivering valuable data on the mechanisms of action of genetic variations on phenotype, and impact of drugs / gene vectors on tumor growth delay and microenvironmental changes. Interested in positions that allow me to continue to mesh important research questions with therapeutically relevant outcomes.

Position - Company  
Scientific Associate - University Health Network

Directing multi-modality imaging experiments on primary human tumor xenografts in an industry-partnered target discovery partnership, with a focus on measuring the influence of the tumor microenvironment on tumor progression and treatment prognosis.

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Jun 2010 - Oct 2014
Postdoctoral Fellow - University Health Network

Postdoctoral Fellowship in the laboratory of Dr. Rama Khokha, Professor in the department of Signaling Biology. I utilized my expertise in multimodality intravital imaging to study the phenotypes of TIMP knockout mice and transgenic mouse models of cancer. I developed multiphoton microscopy techniques and automated analysis algorithms for the study of extracellular matrix remodeling, and merged CT, fluorescence molecular tomography, multispectral imaging and histologic analysis for analysis of the mechanisms of osteosarcoma development. Applied (or helped apply) for and successfully received the Susan G. Komen Postdoctoral Fellowship, US Army Breast Cancer Idea Grant, and a Ontario Provincial Government Global Leadership in Genomics & Life Sciences grant awards.

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Aug 2005 - Jun 2010
Postdoctoral Fellow - University of Toronto 2005 - Jun 2010
Director, Board of Directors; co-chair, Revenue Development, Organizing Committee - Canadian Science Policy Conference

- Responsible for recruitment of sponsors for 300+ attendee conference in Toronto, October 28-30, 2009
- Raised a total of $184,000 in sponsorships from Government, Industry, and Funding Body sources
- Communicated with and managed sponsors prior to and during conference, ensuring their publicity, advertising, and sponsor recognition needs were met
- facilitated the incorporation of a policy centre, and recruitment of a conference manager, to assist with successful conference preparation

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Sep 2008 - Dec 2009
Graduate Student - Harvard Medical School Harvard University 2000 - 2005
Graduate Student - Massachusetts Institute of Technology

- Quantitatively defined physical limitations of particle transport in tumors, explaining fundamental mechanism impeding the success of gene therapy in cancer.
- Developed, validated and patented method to improve gene and antibody delivery utilizing ECM modification.
- Developed noninvasive imaging techniques to track matrix modification in vivo and applied to image relaxin-induced changes on structure; results published in Nature Medicine
- Performed dynamic imaging of cell - ECM interactions in vitro, and drug effects on matrix interactions in vivo; results published in Nature Methods

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1999 - 2005
Engineering Intern, GIBCO Cell Culture Research and Development - Life Technologies

- Participated in the development of a new in vitro diagnostic media product
- Learned and practiced cell culture techniques, including operation of a bioreactor
- Optimized new product manufacturing specifications
- Operated pilot production of new media product

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Jun 1999 - Aug 1999
Undergraduate Student - SUNY at Buffalo 1995 - 1999
Computational Image Analysis Manager

The STTARR Image Analysis team develops machine-learning algorithms (in the Definiens Developer software environment) alongside clinical pathologist annotations to segment digital pathology images of patient samples and animal models across a range of diseases. These algorithms provide quantitative scores for potential clinical biomarkers of interest, and serve to increase throughput and reproducibility of pathological analysis of patient and xenograft samples, for basic research, preclinical trial biomarker assessment and drug testing purposes. We offer custom image analysis solutions for any needs, and bring 15+ years of advanced image analysis capabilities to solving your image analysis problems.

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Oct 2014 - Present
Degree - University  
Certificate, Entrepreneurship - MaRS Discovery District 2007 - 2008
Doctor of Philosophy (Ph.D.), Bioengineering and Biomedical Engineering - Massachusetts Institute of Technology

Quantitatively defined physical limitations of particle transport in tumors, explaining fundamental mechanism impeding the success of gene therapy in cancer. Developed, validated and patented method to improve gene and antibody delivery utilizing ECM modification. Developed noninvasive imaging techniques to track matrix modification in vivo and applied to image relaxin-induced changes on structure; results published in Nature Medicine. Performed dynamic imaging of cell - ECM interactions in vitro, and drug effects on matrix interactions in vivo; results published in Nature Methods. Ph.D. thesis work resulted in ten publications, with over 1000 citations as of 2015

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1999 - 2005
Bachelor of Science (BSc), Chemical and Biomolecular Engineering - SUNY at Buffalo 1995 - 1999
Publication Info
RANKL blockade prevents and treats aggressive osteosarcomas. Chen Y, Di Grappa MA, Molyneux SD, McKee TD, Waterhouse P, Penninger JM, Khokha R Sci Transl Med. 7(317):317ra197. doi: 10.1126/scitranslmed.aad0295. December 9, 2015. View on PubMed.
Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. Molyneux SD, Di Grappa MA, Beristain AG, McKee TD, Wai DH, Paderova J, Kashyap M and 11 others J Clin Invest. 120(9):3310-25. doi: 10.1172/JCI42391. September 2010. View on PubMed.
Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload. Koskivirta I, Kassiri Z, Rahkonen O, Kiviranta R, Oudit GY, McKee TD, Kytö V and 5 others J Biol Chem. 285(32):24487-93. doi: 10.1074/jbc.M110.136820. August 6, 2010. View on PubMed.
In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y Nat Methods. 6(2):143-5. doi: 10.1038/nmeth.1295. February 2009. View on PubMed.
Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. McKee TD, Grandi P, Mok W, Alexandrakis G, Insin N, Zimmer JP, Bawendi MG, Boucher Y, Breakefield XO, Jain RK Cancer Res. 66(5):2509-13. doi: 10.1158/0008-5472.CAN-05-2242. March 1, 2006. View on PubMed.
Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line. Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher Y Cancer Res. 65(13):5674-82. doi: 10.1158/0008-5472.CAN-04-1682. July 1, 2005. View on PubMed.
Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse. Huang P, McKee TD, Jain RK, Fukumura D Comp Med. 55(3):236-43. June 2005. View on PubMed.
Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors. Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK Nat Med. 10(2):203-7. doi: 10.1038/nm981. February 2004. View on PubMed.
Irradiation reduces interstitial fluid transport and increases the collagen content in tumors. Znati CA, Rosenstein M, McKee TD, Brown E, Turner D, Bloomer WD, Watkins S, Jain RK, Boucher Y Clin Cancer Res. 9(15):5508-13. November 15, 2003. View on PubMed.
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK Nat Med. 9(6):796-800. doi: 10.1038/nm879. June 2003. View on PubMed.
Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK Biophys J. 83(3):1650-60. doi: 10.1016/S0006-3495(02)73933-7. September 2002. View on PubMed.
Solid stress facilitates spheroid formation: potential involvement of hyaluronan. Koike C, McKee TD, Pluen A, Ramanujan S, Burton K, Munn LL, Boucher Y, Jain RK Br J Cancer. 86(6):947-53. doi: 10.1038/sj.bjc.6600158. March 18, 2002. View on PubMed.
Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB and 4 others Proc Natl Acad Sci U S A. 98(8):4628-33. doi: 10.1073/pnas.081626898. April 10, 2001. View on PubMed.
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