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Qishan Lin, PhD

Project Administrative Officer - SUNY Research Foundation View Biosketch →

The UAlbany Proteomics Facility was launched in the year of 2002. The Facility provides researchers with access to the state-of-the-art mass spectrometric instrumentation for bio-molecular identification and quantification. The Core offers high-throughput 'omics technologies and platforms for the discovery, quantification, and verification of biomarkers for various diseases; and regularly assists researchers in studying animal models of human diseases, with the characterization of disease states like infectious disease, cancer, neurodegenerative diseases and human aging. Over these years, the Facility has established successful collaborations with, and performed work on a fee-for-service basis for more than 300 clients around the world that include major research institutions, government agencies, scientific organizations, and pharmaceutical companies. The Facility delivers definitive, high quality results in a time and cost effective manner with significant emphasis on client service and value-added solutions. Typical services include but not limit to 1) liquid chromatography, 2) protein purification and quantitation, 3) 1D and 2D gel electrophoresis, 4) sample processing (isotope labeling, enzymatic digestion and fractionation), 5) MALDI-TOF peptide mass fingerprint (PMF), 6) high throughput phosphopeptide mapping (TiO2, IMAC, LC-MS/MS approach), 7) protein expression profiling through MudPIT, iTRAQ, or SILAC, 8) biomarker discovery, 9) metabolite id and quantitation, 10) de novo peptide sequencing, 11) SID-MRM-LC/MS/MS, 12) protein or RNA biopharmaceutical characterization, 13) absolute quantification of nucleoside modifications, and 14) multiple reaction monitoring (MRM)-initiated detection and sequencing (MIDAS) workflow for protein target confirmation.

Position - Company  
Core Director - Proteomics/Mass Spec Facility Center for Functional Genomics Oct 2002 - Present
Research Associate Professor - University at Albany, SUNY Jul 2010 - Present
Project Administrative Officer - SUNY Research Foundation Aug 2005 - Present
Degree - University  
PostDoc, Molecular and Cellular Physiology - Albany Medical College 2000 - 2001
PostDoc, Biochemistry - Howard Huges Medical Institute, University of Washington 1997 - 2000
Ph.D., Analytical Chemistry - Institute of Chemistry of the Chinese Acadmy of Sciences 1993 - 1996
MS, Organic Chemistry - Institute of Photographic Chemistry of Chinese Acadmy of Sciences 1988 - 1991
BS, Applied Chemistry - National University of Defense Technology (NUDT) 1984 - 1988
Publication Info
Efficacy and tolerability of AFPep, a cyclic peptide with anti-breast cancer properties. Mansouri W, Fordyce SB, Wu M, Jones D, Cohn D, Lin Q, Feustel P, Sharma T, Bennett JA, Andersen TT Toxicol Appl Pharmacol. :. doi: 10.1016/j.taap.2018.03.004. March 5, 2018. View on PubMed.
Heavy Chronic Intermittent Ethanol Exposure Alters Small Noncoding RNAs in Mouse Sperm and Epididymosomes. Rompala GR, Mounier A, Wolfe CM, Lin Q, Lefterov I, Homanics GE Front Genet. 9:32. doi: 10.3389/fgene.2018.00032. 2018. View on PubMed.
Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction. Li Z, Brecher M, Deng YQ, Zhang J, Sakamuru S, Liu B, Huang R and 15 others Cell Res. :. doi: 10.1038/cr.2017.88. July 7, 2017. View on PubMed.
A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease. Brecher M, Li Z, Liu B, Zhang J, Koetzner CA, Alifarag A, Jones SA, Lin Q, Kramer LD, Li H PLoS Pathog. 13(5):e1006411. doi: 10.1371/journal.ppat.1006411. May 2017. View on PubMed.
Self-assembly of green tea catechin derivatives in nanoparticles for oral lycopene delivery. Li W, Yalcin M, Lin Q, Ardawi MM, Mousa SA J Control Release. 248:117-124. doi: 10.1016/j.jconrel.2017.01.009. February 28, 2017. View on PubMed.
Metabolic profiles revealed synergistically antidepressant effects of lilies and Rhizoma Anemarrhenae in a rat model of depression. Du H, Zhao H, Lai X, Lin Q, Zhu Z, Chai Y, Lou Z Biomed Chromatogr. :. doi: 10.1002/bmc.3923. December 23, 2016. View on PubMed.
Metabonomic identification of the effects of the Zhimu-Baihe saponins on a chronic unpredictable mild stress-induced rat model of depression. Du H, Wang K, Su L, Zhao H, Gao S, Lin Q, Ma X, Zhu B, Dong X, Lou Z J Pharm Biomed Anal. 128:469-79. doi: 10.1016/j.jpba.2016.06.019. September 5, 2016. View on PubMed.
Hyperinsulinemia enhances interleukin-17-induced inflammation to promote prostate cancer development in obese mice through inhibiting glycogen synthase kinase 3-mediated phosphorylation and degradation of interleukin-17 receptor. Liu S, Zhang Q, Chen C, Ge D, Qu Y, Chen R, Fan YM and 12 others Oncotarget. 7(12):13651-66. doi: 10.18632/oncotarget.7296. March 22, 2016. View on PubMed.
Urinary metabonomics elucidate the therapeutic mechanism of Orthosiphon stamineus in mouse crystal-induced kidney injury. Gao S, Chen W, Peng Z, Li N, Su L, Lv D, Li L and 4 others J Ethnopharmacol. 166:323-32. doi: 10.1016/j.jep.2015.03.025. May 26, 2015. View on PubMed.
A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling. Lin HY, Haegele JA, Disare MT, Lin Q, Aye Y J Am Chem Soc. 137(19):6232-44. doi: 10.1021/ja5132648. May 20, 2015. View on PubMed.
Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase. Brecher MB, Li Z, Zhang J, Chen H, Lin Q, Liu B, Li H Protein Sci. 24(1):117-28. doi: 10.1002/pro.2594. January 2015. View on PubMed.
Identification of Signaling Protein Complexes by Parallel Affinity Precipitation Coupled with Mass Spectrometry. Lu H, Lin Q, Zhao J Cell Commun Insights. 5:1-7. doi: 10.4137/CCI.S12484. September 11, 2013. View on PubMed.
Large-scale production of functional human serum albumin from transgenic rice seeds. He Y, Ning T, Xie T, Qiu Q, Zhang L, Sun Y, Jiang D and 11 others Proc Natl Acad Sci U S A. 108(47):19078-83. doi: 10.1073/pnas.1109736108. November 22, 2011. View on PubMed.
Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating protein. Lu H, Wang X, Li T, Urvalek AM, Yu L, Li J, Zhu J, Lin Q, Peng X, Zhao J J Biol Chem. 286(23):20335-44. doi: 10.1074/jbc.M110.215632. June 10, 2011. View on PubMed.
Autophagy-dependent regulation of the DNA damage response protein ribonucleotide reductase 1. Dyavaiah M, Rooney JP, Chittur SV, Lin Q, Begley TJ Mol Cancer Res. 9(4):462-75. doi: 10.1158/1541-7786.MCR-10-0473. April 2011. View on PubMed.
Regulation of the oncoprotein KLF8 by a switch between acetylation and sumoylation. Urvalek AM, Lu H, Wang X, Li T, Yu L, Zhu J, Lin Q, Zhao J Am J Transl Res. 3(2):121-32. February 2011. View on PubMed.
Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease. Gong Y, Lippa CF, Zhu J, Lin Q, Rosso AL Brain Res. 1292:191-8. doi: 10.1016/j.brainres.2009.07.056. October 6, 2009. View on PubMed.
Understanding rice plant resistance to the Brown Planthopper (Nilaparvata lugens): a proteomic approach. Wei Z, Hu W, Lin Q, Cheng X, Tong M, Zhu L, Chen R, He G Proteomics. 9(10):2798-808. doi: 10.1002/pmic.200800840. May 2009. View on PubMed.
Proteomic analysis of rice endosperm cells in response to expression of hGM-CSF. Luo J, Ning T, Sun Y, Zhu J, Zhu Y, Lin Q, Yang D J Proteome Res. 8(2):829-37. doi: 10.1021/pr8002968. February 2009. View on PubMed.
Identifying the subproteome of kinetically stable proteins via diagonal 2D SDS/PAGE. Xia K, Manning M, Hesham H, Lin Q, Bystroff C, Colón W Proc Natl Acad Sci U S A. 104(44):17329-34. doi: 10.1073/pnas.0705417104. October 30, 2007. View on PubMed.
Proteomics analysis and protein expression during sporozoite excystation of Cryptosporidium parvum (Coccidia, Apicomplexa). Snelling WJ, Lin Q, Moore JE, Millar BC, Tosini F, Pozio E, Dooley JS, Lowery CJ Mol Cell Proteomics. 6(2):346-55. doi: 10.1074/mcp.M600372-MCP200. February 2007. View on PubMed.
BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. Cismasiu VB, Adamo K, Gecewicz J, Duque J, Lin Q, Avram D Oncogene. 24(45):6753-64. doi: 10.1038/sj.onc.1208904. October 13, 2005. View on PubMed.
Interaction of ACE2 and integrin beta1 in failing human heart. Lin Q, Keller RS, Weaver B, Zisman LS Biochim Biophys Acta. 1689(3):175-8. doi: 10.1016/j.bbadis.2004.05.005. August 4, 2004. View on PubMed.
Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2. Zisman LS, Keller RS, Weaver B, Lin Q, Speth R, Bristow MR, Canver CC Circulation. 108(14):1707-12. doi: 10.1161/01.CIR.0000094734.67990.99. October 7, 2003. View on PubMed.
Rating  
From Isaac Erickson (University of Minnesota - Twin Cities) on 2017-05-08 06:59:56 -0700 Dr Lin analyzed and produced the results within 3 days of receiving the sample. His price was co... Read more
From Michael Quintero (King Industries, Inc.) on 2016-11-14 07:05:51 -0800 We have just completed our fist project with Science Exchange Service and Proteomics/Mass from Un... Read more
From D Arrendel (usv llc) on 2015-10-13 12:40:41 -0700 Absolutely excellent and professional service, friendly staff, will definitely use again. Read more
From Peisheng Hu (University of Southern California) on 2015-08-10 10:14:26 -0700 Quick response, excellent work, very satisfied. Read more
From Debasish Bandyopadhyay (University of Texas Rio Grande Valley) on 2015-05-03 18:15:36 -0700 Qishan is extremely prompt and helpful. Read more
From Debasish Bandyopadhyay (University of Texas Rio Grande Valley) on 2015-04-20 15:21:01 -0700 Qishan is extremely prompt and helpful. Read more
From Robert Rhinehart (Rosa Labs) on 2014-07-17 14:28:33 -0700 Machine was down but he pulled through anyways Read more
From Roshan Karki (Biomedical Research Institute) on 2012-11-20 11:45:57 -0800 Excellent service all around! Read more
From Roshan Karki (Biomedical Research Institute) on 2012-08-06 10:04:23 -0700 Excellent service and turnaround time Read more
From Roshan Karki (Biomedical Research Institute) on 2012-04-17 05:33:48 -0700 Excellent Service, quick turn-around time, and results returned in easy-to-read format. I would h... Read more