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Ian Paul

Director, Animal Behavioral Core, Center for Psychiatric Neuroscience - University of Mississippi Medical Center View Biosketch →

Position - Company  
Director, Graduate Program in Neuroscience - University of Mississippi Medical Center

I began developing the Graduate Program in Neuroscience (PIN) in December, 2005 and have guided it through proposal, certification by the Mississippi Institutions of Higher Learning and inception. The PIN represents the first interdepartmental graduate training program on this campus and includes 42 active faculty in 15 departments. Beginning with 4 students in 2007, we now have 12 Ph.D. and 1 M.D./Ph.D. student. Our first student received her Ph.D. in 2010.

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Jan 2007 - Jun 2014
Director, Mentoring & Education Core, Center for Psychiatric Neuroscience - University of Mississippi Medical Center

As director of the Mentoring and Education Core of the CPN, I focus on developing young scientists by organizing training seminars, mentoring junior faculty in research and teaching. I also direct the Neuroscience Scholars Summer Program, a highly successful 10 week internship program for Mississippi undergraduates working in laboratory of the CPN and the Program in Neuroscience.

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Jul 2007 - Jun 2012
Staff Fellow - National Institute of Health

I worked in the Laboratory of Neuroscience run by Dr. Phil Skolnick. My primary focus was on the role of excitatory amino acid neurotransmitters in the mechanism of action of antidepressants. In addition, I developed behavioral paradigms to test the functional effects of retroviral infection in rodents.

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1989 - 1993
Graduate Assistant - University of North Carolina at Chapel Hill 1983 - 1989
Student Assistant - University of Pittsburgh 1982 - 1983
Director, Animal Behavioral Core, Center for Psychiatric Neuroscience - University of Mississippi Medical Center

I direct the Animal Behavioral Core for the CPN which is a 1000 sq. ft. facility conducting state of the art rodent behavioral testing for investigators at UMC and other nearby institutions. The core facility is equipped to perform a comprehensive battery of behavioral tests to thoroughly phenotype overall motor and sensory function of rats and mice as well as specific behaviors of interest to specific investigators (learning and memory, motor function and gait, place/fear conditioning, pain/analgesia, depression- and anxiety-related behaviors). The Core is equipped to assist in all aspects of rodent behavioral testing including design and execution of behavioral tasks as well as data analysis and interpretation.

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Jan 2010 - Present
Professor of Psychiatry & Human Behavior - University of Mississippi Medical Center

As a professor of Psychiatry and Human Behavior, I am active in teaching residents and medical students and maintain an active and funded research laboratory focused on the neurodevelopmental effects of psychotherapeutic drugs and, in particular, antidepressant medications.

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Jun 1993 - Present
Associate Professor of Pharmacology & Toxicology - University of Mississippi Medical Center

As associate professor of Pharmacology and Toxicology, I participate in teaching CNS pharmacology to medical and graduate students and mentor students from the department completing dissertation research in my laboratory.

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Jun 1993 - Present
Professor, Department of Neurobiology & Anatomical Sciences - University of Mississippi Medical Center Jul 2013 - Present
Degree - University  
Postdoctoral training, Neuroscience - National Insistutes of Health, NIDDK, Laboratory of Neuroscience

Postdoctoral trainee with Dr. Phil Skolnick focused on the interaction of antidepressant drugs with the N-Methyl-D-Aspartate (NMDA) receptor. In addition, collaborated with Dr. Yoshitatsu Sei in studying the neurocognitive effects of the LP-BM5 retroviral mixture as a model of neuroAIDs.

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1989 - 1993
PhD, Neurobiology - University of North Carolina at Chapel Hill School of Medicine University of North Carolina at Chapel Hill

Graduate student with Dr. George Breese studying the interaction of antidepressant medication and the forced swim test in rats on the regulation of forebrain beta-adrenoceptors. In addition, worked under Dr. John Hong at the NIEHS studying the effect of antidepressants and stress on the expression of opioid peptides in CNS.

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1983 - 1989
B.S., Behavioral Neuroscience - University of Pittsburgh 1981 - 1983
Publication Info
Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders. Khatri N, Simpson KL, Lin RC, Paul IA Psychopharmacology (Berl). 231(6):1191-200. doi: 10.1007/s00213-013-3242-2. March 2014. View on PubMed.
Neonatal citalopram exposure decreases serotonergic fiber density in the olfactory bulb of male but not female adult rats. Zhang J, Dennis KA, Darling RD, Alzghoul L, Paul IA, Simpson KL, Lin RC Front Cell Neurosci. 7:67. doi: 10.3389/fncel.2013.00067. May 10, 2013. View on PubMed.
Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β1-40. Miguel-Hidalgo JJ, Paul IA, Wanzo V, Banerjee PK Eur J Pharmacol. 692(1-3):38-45. doi: 10.1016/j.ejphar.2012.07.032. October 5, 2012. View on PubMed.
Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression. Grunewald M, Johnson S, Lu D, Wang Z, Lomberk G, Albert PR, Stockmeier CA and 10 others J Biol Chem. 287(29):24195-206. doi: 10.1074/jbc.M112.373936. July 13, 2012. View on PubMed.
Dose-dependent effects of neonatal SSRI exposure on adult behavior in the rat. Harris SS, Maciag D, Simpson KL, Lin RC, Paul IA Brain Res. 1429:52-60. doi: 10.1016/j.brainres.2011.10.025. January 6, 2012. View on PubMed.
Perinatal citalopram exposure selectively increases locus ceruleus circuit function in male rats. Darling RD, Alzghoul L, Zhang J, Khatri N, Paul IA, Simpson KL, Lin RC J Neurosci. 31(46):16709-15. doi: 10.1523/JNEUROSCI.3736-11.2011. November 16, 2011. View on PubMed.
Perinatal antidepressant exposure alters cortical network function in rodents. Simpson KL, Weaver KJ, de Villers-Sidani E, Lu JY, Cai Z, Pang Y, Rodriguez-Porcel F, Paul IA, Merzenich M, Lin RC Proc Natl Acad Sci U S A. 108(45):18465-70. doi: 10.1073/pnas.1109353108. November 8, 2011. View on PubMed.
Neonatal exposure of rats to antidepressants affects behavioral reactions to novelty and social interactions in a manner analogous to autistic spectrum disorders. Rodriguez-Porcel F, Green D, Khatri N, Harris SS, May WL, Lin RC, Paul IA Anat Rec (Hoboken). 294(10):1726-35. doi: 10.1002/ar.21402. October 2011. View on PubMed.
Altered expression of tyrosine hydroxylase in the locus coeruleus noradrenergic system in citalopram neonatally exposed rats and monoamine oxidase a knock out mice. Zhang J, Darling RD, Paul IA, Simpson KL, Chen K, Shih JC, Lin RC Anat Rec (Hoboken). 294(10):1685-97. doi: 10.1002/ar.21350. October 2011. View on PubMed.
Ethanol increases TIEG2-MAO B cell death cascade in the prefrontal cortex of ethanol-preferring rats. Ou XM, Johnson C, Lu D, Johnson S, Paul IA, Austin MC, Iyo AH and 6 others Neurotox Res. 19(4):511-8. doi: 10.1007/s12640-010-9164-4. May 2011. View on PubMed.
Neonatal exposure to citalopram selectively alters the expression of the serotonin transporter in the hippocampus: dose-dependent effects. Weaver KJ, Paul IA, Lin RC, Simpson KL Anat Rec (Hoboken). 293(11):1920-32. doi: 10.1002/ar.21245. November 2010. View on PubMed.
mu-Opioid receptor knockout mice are insensitive to methamphetamine-induced behavioral sensitization. Shen X, Purser C, Tien LT, Chiu CT, Paul IA, Baker R, Loh HH, Ho IK, Ma T J Neurosci Res. 88(10):2294-302. doi: 10.1002/jnr.22386. August 1, 2010. View on PubMed.
Interleukin-10/Ceftriaxone prevents E. coli-induced delays in sensorimotor task learning and spatial memory in neonatal and adult Sprague-Dawley rats. Wallace KL, Lopez J, Shaffery JP, Wells A, Paul IA, Bennett WA Brain Res Bull. 81(1):141-8. doi: 10.1016/j.brainresbull.2009.10.016. January 15, 2010. View on PubMed.
Zinc supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study. Siwek M, Dudek D, Paul IA, Sowa-Kućma M, Zieba A, Popik P, Pilc A, Nowak G J Affect Disord. 118(1-3):187-95. doi: 10.1016/j.jad.2009.02.014. November 2009. View on PubMed.
Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development. Maciag D, Coppinger D, Paul IA Brain Res. 1125(1):171-5. doi: 10.1016/j.brainres.2006.10.009. December 13, 2006. View on PubMed.
Motor functions but not learning and memory are impaired upon repeated exposure to sub-lethal doses of methyl parathion. Sun TT, Paul IA, Ho IK J Biomed Sci. 13(4):515-23. doi: 10.1007/s11373-006-9075-9. July 2006. View on PubMed.
Nicotinamide reduces hypoxic ischemic brain injury in the newborn rat. Feng Y, Paul IA, LeBlanc MH Brain Res Bull. 69(2):117-22. doi: 10.1016/j.brainresbull.2005.11.011. March 31, 2006. View on PubMed.
Neonatal citalopram exposure produces lasting changes in behavior which are reversed by adult imipramine treatment. Maciag D, Williams L, Coppinger D, Paul IA Eur J Pharmacol. 532(3):265-9. doi: 10.1016/j.ejphar.2005.12.081. February 27, 2006. View on PubMed.
Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry. Maciag D, Simpson KL, Coppinger D, Lu Y, Wang Y, Lin RC, Paul IA Neuropsychopharmacology. 31(1):47-57. doi: 10.1038/sj.npp.1300823. January 2006. View on PubMed.
Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice. Aricioglu F, Paul IA, Regunathan S Neurosci Lett. 354(2):153-7. January 9, 2004. View on PubMed.
Glutamate and depression: clinical and preclinical studies. Paul IA, Skolnick P Ann N Y Acad Sci. 1003:250-72. November 2003. View on PubMed.
Non-adrenergic exploratory behavior induced by moxonidine at mildly hypotensive doses. Zhu H, Paul IA, Stec DE, Peeler DF, Piletz JE Brain Res. 964(1):9-20. February 21, 2003. View on PubMed.
Reinforcing strength of a novel dopamine transporter ligand: pharmacodynamic and pharmacokinetic mechanisms. Woolverton WL, Ranaldi R, Wang Z, Ordway GA, Paul IA, Petukhov P, Kozikowski A J Pharmacol Exp Ther. 303(1):211-7. doi: 10.1124/jpet.102.037812. October 2002. View on PubMed.
Effects of LP-BM5 murine leukemia virus infection on errors and response time in a two-choice serial reaction time task in C57BL/6 mice. Lee B, Tumu P, Paul IA Brain Res. 948(1-2):1-7. September 6, 2002. View on PubMed.
Effect of NOS inhibitor on forced swim test and neurotransmitters turnover in the mouse brain. Karolewicz B, Paul IA, Antkiewicz-Michaluk L Pol J Pharmacol. 53(6):587-96. December 2001. View on PubMed.
Role of the dopamine transporter and the sodium channel in the cocaine-like discriminative stimulus effects of local anesthetics in rats. Wilcox KM, Paul IA, Ordway GA, Woolverton WL Psychopharmacology (Berl). 157(3):260-8. doi: 10.1007/s002130100796. September 2001. View on PubMed.
Group housing of mice increases immobility and antidepressant sensitivity in the forced swim and tail suspension tests. Karolewicz B, Paul IA Eur J Pharmacol. 415(2-3):197-201. March 2001. View on PubMed.
Antidepressant activity and calcium signaling cascades. Paul IA Hum Psychopharmacol. 16(1):71-80. doi: 10.1002/hup.186. January 2001. View on PubMed.
On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: practical and theoretical concerns. Wilcox KM, Rowlett JK, Paul IA, Ordway GA, Woolverton WL Psychopharmacology (Berl). 153(1):139-47. December 2000. View on PubMed.
Sucrose and quinine intake by maternally-deprived and control rhesus monkeys. Paul IA, English JA, Halaris A Behav Brain Res. 112(1-2):127-34. July 2000. View on PubMed.
Corrigendum to: "Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors" Harkin A, Nowak G, Paul IA Eur J Pharmacol. 397(2-3):399. June 2, 2000. View on PubMed.
LP-BM5 infection impairs spatial working memory in C57BL/6 mice in the Morris water maze. Lee B, English JA, Paul IA Brain Res. 856(1-2):129-34. February 21, 2000. View on PubMed.
Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors. Harkin A, Nowak G, Paul IA Eur J Pharmacol. 389(2-3):187-92. February 18, 2000. View on PubMed.
Chronic glycine treatment desensitizes the behavioral response to 1-aminocyclopropanecarboxylic acid (ACPC), a partial agonist at the strychnine-insensitive glycine site of the NMDA receptor complex. Nowak G, Li Y, Paul IA J Neural Transm. 107(2):123-31. doi: 10.1007/s007020050011. 2000. View on PubMed.
3'- and 4'-chloro-substituted analogs of benztropine: intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys. Woolverton WL, Rowlett JK, Wilcox KM, Paul IA, Kline RH, Newman AH, Katz JL Psychopharmacology (Berl). 147(4):426-35. January 2000. View on PubMed.
Prenatal hypoxia-ischemia alters expression and activity of nitric oxide synthase in the young rat brain and causes learning deficits. Cai Z, Xiao F, Lee B, Paul IA, Rhodes PG Brain Res Bull. 49(5):359-65. July 15, 1999. View on PubMed.
Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 2. Chronic treatment results in downregulation of cortical beta-adrenoceptors. Karolewicz B, Bruce KH, Lee B, Paul IA Eur J Pharmacol. 372(3):215-20. May 21, 1999. View on PubMed.
Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test. Harkin AJ, Bruce KH, Craft B, Paul IA Eur J Pharmacol. 372(3):207-13. May 21, 1999. View on PubMed.
Comparison between dopamine transporter affinity and self-administration potency of local anesthetics in rhesus monkeys. Wilcox KM, Paul IA, Woolverton WL Eur J Pharmacol. 367(2-3):175-81. February 19, 1999. View on PubMed.
Increased discriminative stimulus potency of phencyclidine in C57B1/6 mice infected with the LP-BM5 retrovirus. English JA, Bruce KH, Paul IA Eur J Pharmacol. 367(1):1-5. February 12, 1999. View on PubMed.
Dopamine D1 and D2 receptor selectivities of phenyl-benzazepines in rhesus monkey striata. Weed MR, Woolverton WL, Paul IA Eur J Pharmacol. 361(1):129-42. November 13, 1998. View on PubMed.
LP-BM5 infection impairs acquisition, but not performance, of active avoidance responding in C57B1/6 mice. English JA, Hemphill KM, Paul IA FASEB J. 12(2):175-9. February 1998. View on PubMed.
The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys. Weed MR, Paul IA, Dwoskin LP, Moore SE, Woolverton WL J Pharmacol Exp Ther. 283(1):29-38. October 1997. View on PubMed.
Developmental lead exposure and two-way active avoidance training alter the distribution of protein kinase C activity in the rat hippocampus. Chen HH, Ma T, Paul IA, Spencer JL, Ho IK Neurochem Res. 22(9):1119-25. September 1997. View on PubMed.
Chronic imipramine treatment upregulates IR2-imidazoline receptive sites in rat brain. Zhu H, Paul IA, McNamara M, Redmond A, Nowak G, Piletz JE Neurochem Int. 30(1):101-7. January 1997. View on PubMed.
Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils. Von Lubitz DK, Lin RC, Paul IA, Beenhakker M, Boyd M, Bischofberger N, Jacobson KA Eur J Pharmacol. 316(2-3):171-9. December 5, 1996. View on PubMed.
Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist. Von Lubitz DK, Beenhakker M, Lin RC, Carter MF, Paul IA, Bischofberger N, Jacobson KA Eur J Pharmacol. 302(1-3):43-8. April 29, 1996. View on PubMed.
Altered brain fyn kinase in a murine acquired immunodeficiency syndrome. Sei Y, Whitesell L, Kustova Y, Paul IA, Morse HC 3rd, Skolnick P, Basile AS FASEB J. 10(2):339-44. February 1996. View on PubMed.
Adaptation of cortical but not hippocampal NMDA receptors after chronic citalopram treatment. Nowak G, Li Y, Paul IA Eur J Pharmacol. 295(1):75-85. January 4, 1996. View on PubMed.
Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression. Skolnick P, Layer RT, Popik P, Nowak G, Paul IA, Trullas R Pharmacopsychiatry. 29(1):23-6. doi: 10.1055/s-2007-979537. January 1996. View on PubMed.
Quinolinic acid levels in a murine retrovirus-induced immunodeficiency syndrome. Sei Y, Paul IA, Saito K, Layar R, Hartley JW, Morse HC 3rd, Skolnick P, Heyes MP J Neurochem. 66(1):296-302. January 1996. View on PubMed.
Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Nowak G, Ordway GA, Paul IA Brain Res. 675(1-2):157-64. March 27, 1995. View on PubMed.
Swim stress increases the potency of glycine at the N-methyl-D-aspartate receptor complex. Nowak G, Redmond A, McNamara M, Paul IA J Neurochem. 64(2):925-7. February 1995. View on PubMed.
Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. Paul IA, Nowak G, Layer RT, Popik P, Skolnick P J Pharmacol Exp Ther. 269(1):95-102. April 1994. View on PubMed.
Chronic adenosine A1 receptor agonist and antagonist: effect on receptor density and N-methyl-D-aspartate induced seizures in mice. Von Lubitz DK, Paul IA, Ji XD, Carter M, Jacobson KA Eur J Pharmacol. 253(1-2):95-9. February 21, 1994. View on PubMed.
Multiple [3H]DTG binding sites in guinea pig cerebellum: evidence for the presence of non-specific binding. Basile AS, DeCosta B, Paul IA Eur J Pharmacol. 252(2):139-46. February 3, 1994. View on PubMed.
Effects of chronic administration of adenosine A1 receptor agonist and antagonist on spatial learning and memory. Von Lubitz DK, Paul IA, Bartus RT, Jacobson KA Eur J Pharmacol. 249(3):271-80. November 16, 1993. View on PubMed.
Effects of N6-cyclopentyl adenosine and 8-cyclopentyl-1,3-dipropylxanthine on N-methyl-D-aspartate induced seizures in mice. Von Lubitz DK, Paul IA, Carter M, Jacobson KA Eur J Pharmacol. 249(3):265-70. November 16, 1993. View on PubMed.
Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine. Paul IA, Layer RT, Skolnick P, Nowak G Eur J Pharmacol. 247(3):305-11. November 15, 1993. View on PubMed.
Ca2+ antagonists effect an antidepressant-like adaptation of the NMDA receptor complex. Nowak G, Paul IA, Popik P, Young A, Skolnick P Eur J Pharmacol. 247(1):101-2. September 15, 1993. View on PubMed.
Requirements for high affinity binding of glycine analogs to the glycine site of the NMDA receptor complex. Lewin AH, Skolnick P, Marvizon JC, Paul IA, Bowen JP Eur J Pharmacol. 247(1):1-10. September 15, 1993. View on PubMed.
Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells. Paul IA, Basile AS, Rojas E, Youdim MB, De Costa B, Skolnick P, Pollard HB, Kuijpers GA FASEB J. 7(12):1171-8. September 1993. View on PubMed.
Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid. Nowak G, Trullas R, Layer RT, Skolnick P, Paul IA J Pharmacol Exp Ther. 265(3):1380-6. June 1993. View on PubMed.
Neuroanatomical differences in the rate of beta-adrenergic receptor adaptation after repeated treatment with imipramine. Duncan GE, Paul IA, Breese GR Psychopharmacol Bull. 29(3):401-7. 1993. View on PubMed.
Modulation of (+)-[3H]pentazocine binding to guinea pig cerebellum by divalent cations. Basile AS, Paul IA, Mirchevich A, Kuijpers G, De Costa B Mol Pharmacol. 42(5):882-9. November 1992. View on PubMed.
Differential effects of cytochrome P-450 induction on ligand binding to sigma receptors. Basile AS, Paul IA, de Costa B Eur J Pharmacol. 227(1):95-8. September 1, 1992. View on PubMed.
Spatial learning impairment in a murine model of AIDS. Sei Y, Arora PK, Skolnick P, Paul IA FASEB J. 6(11):3008-13. August 1992. View on PubMed.
Down-regulation of cortical beta-adrenoceptors by chronic treatment with functional NMDA antagonists. Paul IA, Trullas R, Skolnick P, Nowak G Psychopharmacology (Berl). 106(2):285-7. 1992. View on PubMed.
Neural adaptation in response to chronic imipramine and electroconvulsive shock: evidence for separate mechanisms. Paul IA, Duncan GE, Mueller RA, Hong JS, Breese GR Eur J Pharmacol. 205(2):135-43. November 26, 1991. View on PubMed.
Down-regulation of dopamine1 (D1) receptors by chronic imipramine is species-specific. Nowak G, Skolnick P, Paul IA Pharmacol Biochem Behav. 39(3):769-71. July 1991. View on PubMed.
Autoradiographic analysis of the in vivo distribution of 3H-imipramine and 3H-desipramine in brain: comparison to in vitro binding patterns. Duncan GE, Paul IA, Fassberg JB, Powell KR, Stumpf WE, Breese GR Pharmacol Biochem Behav. 38(3):621-31. March 1991. View on PubMed.
Polyamines non-competitively inhibit [3H]3-PPP binding to sigma receptors. Paul IA, Kuypers G, Youdim M, Skolnick P Eur J Pharmacol. 184(1):203-4. August 2, 1990. View on PubMed.
Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake. Paul IA, Duncan GE, Kuhn C, Mueller RA, Hong JS, Breese GR J Pharmacol Exp Ther. 252(3):997-1005. March 1990. View on PubMed.
Angel dust and other antagonists. Neurobiology of the NMDA Receptor: from Chemistry to Clinic, sponsored by the Society for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA, October 27-28, 1989. Paul IA New Biol. 2(2):139-41. February 1990. View on PubMed.
Neuroanatomically selective down-regulation of beta adrenergic receptors by chronic imipramine treatment: relationships to the topography of [3H]imipramine and [3H] desipramine binding sites. Duncan GE, Paul IA, Powell KR, Fassberg JB, Stumpf WE, Breese GR J Pharmacol Exp Ther. 248(1):470-7. January 1989. View on PubMed.
Regionally specific neural adaptation of beta adrenergic and 5-hydroxytryptamine2 receptors after antidepressant administration in the forced swim test and after chronic antidepressant drug treatment. Paul IA, Duncan GE, Powell KR, Mueller RA, Hong JS, Breese GR J Pharmacol Exp Ther. 246(3):956-62. September 1988. View on PubMed.
Behavioral and neurochemical responses to haloperidol and SCH-23390 in rats treated neonatally or as adults with 6-hydroxydopamine. Duncan GE, Criswell HE, McCown TJ, Paul IA, Mueller RA, Breese GR J Pharmacol Exp Ther. 243(3):1027-34. December 1987. View on PubMed.
Rapid down regulation of beta adrenergic receptors by combining antidepressant drugs with forced swim: a model of antidepressant-induced neural adaptation. Duncan GE, Paul IA, Harden TK, Mueller RA, Stumpf WE, Breese GR J Pharmacol Exp Ther. 234(2):402-8. August 1985. View on PubMed.
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