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T Downing

Postdoctoral fellow - Genomics

Position - Company  
Postdoctoral fellow - Genomics Wellcome Trust Sanger Institute 2011 - Present
Degree - University  
Ph.D., Evolutionary genetics - Trinity College Dublin 2005 - 2009
M.Sc., Bioinformatics - Dublin City University 2004 - 2005
B.A. (Mod), Human Genetics - Trinity College Dublin 2000 - 2004
Publication Info
Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex. Downing T, Stark O, Vanaerschot M, Imamura H, Sanders M, Decuypere S, de Doncker S and 6 others Infect Genet Evol. 12(1):149-59. doi: 10.1016/j.meegid.2011.11.005. January 2012. View on PubMed.
The battle of the SNPs. Downing T Nat Rev Microbiol. 10(1):6. doi: 10.1038/nrmicro2716. December 5, 2011. View on PubMed.
Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance. Downing T, Imamura H, Decuypere S, Clark TG, Coombs GH, Cotton JA, Hilley JD and 13 others Genome Res. 21(12):2143-56. doi: 10.1101/gr.123430.111. December 2011. View on PubMed.
Genomic instability and oncogene amplifications in colorectal adenomas predict recurrence and synchronous carcinoma. Habermann JK, Brucker CA, Freitag-Wolf S, Heselmeyer-Haddad K, Kr├╝ger S, Barenboim L, Downing T and 4 others Mod Pathol. 24(4):542-55. doi: 10.1038/modpathol.2010.217. April 2011. View on PubMed.
The differential evolutionary dynamics of avian cytokine and TLR gene classes. Downing T, Lloyd AT, O'Farrelly C, Bradley DG J Immunol. 184(12):6993-7000. doi: 10.4049/jimmunol.0903092. June 15, 2010. View on PubMed.
Variation in chicken populations may affect the enzymatic activity of lysozyme. Downing T, O'Farrelly C, Bhuiyan AK, Silva P, Naqvi AN, Sanfo R, Sow RS, Podisi B, Hanotte O, Bradley DG Anim Genet. 41(2):213-7. doi: 10.1111/j.1365-2052.2009.01974.x. April 2010. View on PubMed.
Evidence of the adaptive evolution of immune genes in chicken. Downing T, Cormican P, O'Farrelly C, Bradley DG, Lloyd AT BMC Res Notes. 2:254. doi: 10.1186/1756-0500-2-254. December 15, 2009. View on PubMed.
Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus. Downing T, Lynn DJ, Connell S, Lloyd AT, Bhuiyan AK, Silva P, Naqvi AN and 6 others BMC Evol Biol. 9:136. doi: 10.1186/1471-2148-9-136. June 15, 2009. View on PubMed.
The avian Toll-Like receptor pathway--subtle differences amidst general conformity. Cormican P, Lloyd AT, Downing T, Connell SJ, Bradley D, O'Farrelly C Dev Comp Immunol. 33(9):967-73. doi: 10.1016/j.dci.2009.04.001. April 24, 2009. View on PubMed.
Contrasting evolution of diversity at two disease-associated chicken genes. Downing T, Lynn DJ, Connell S, Lloyd AT, Bhuiyan AK, Silva P, Naqvi AN and 6 others Immunogenetics. 61(4):303-14. doi: 10.1007/s00251-009-0359-x. February 27, 2009. View on PubMed.
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