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Lenore Martin

Position - Company  
Assistant Professor - University of Rhode Island

Tenure-track position in the College of Pharmacy, taught natural products and biotechnology drugs. Developed teaching labs for pharmacy students that emphasized the biochemistry of typical clinical lab tests and the effects of drug therapy on such test results. Developed a part of the drug metabolism course that focused on proteases and peptide-derived drug metabolism. Developed Biotechnology curriculum with emphasis on analytical and physical biochemistry techniques for QC of biotech drugs. Started integrated research program using Molecular Modeling, Combinatorial Solid-Phase Synthesis, and Capillary Electrophoresis to design, synthesize, and evaluate novel topoisomerase inhibitors for use in cancer chemotherapy.

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Jun 1994 - May 2002
Research Associate - Rockefeller University

Professional Training with Prof R.B. Merrifield, supported by NIH (PHS) funding in Peptide Chemistry, Biochemistry, Analytical Chemistry, and Immunology.

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1989 - 1994
Graduate Student - University of California, Los Angeles

Organic Synthesis of DNA-binding drug candidates involving 2,4-linked thiazoles. Photochemistry of benzotropones and psoralens. Synthesized large quantities of short DNA oligomers for use in 2D-NMR studies of DNA-drug interactions @ 500 MHz.Organic Synthesis of DNA-binding drug candidates. Photochemistry of benzotropones and psoralens. Synthesized large quantities of short DNA oligomers for use in 2D-NMR studies of DNA-drug interactions @ 500 MHz. ESR, fluorescence quenching, and lots of HPLC studies. Some GC-MS and photoresists-polymer photochemistry, plus molecular computations for modeling and solving synthetic bioorganic, NMR, and X-ray structural problems focused on biopolymer-drug interactions.

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1983 - 1989
Associate Professor - University of Rhode Island

Teaching, Service, and Research in Biochemistry.
Combinatorial Libraries, Antimicrobial Peptide Chemistry, Analytical Biochemistry, Bioinformatics, and Structural Biology.

We investigate the complex interactions between biopolymers (peptides, proteins, DNA, RNA, lipids, and carbohydrates) in order to understand cellular physiology at the molecular level. My research at URI has focused on using solid-phase peptide synthesis (SPPS) to prepare diverse combinatorial libraries of both naturally-occurring and engineered peptides for further study. We have designed antimicrobial peptides (AMPs) based upon pleurocidin, isolated from Winter Flounder, to combat the growing problem of antimicrobial resistance in pathogenic microbes, and topoisomerase inhibitors based on natural products for use in cancer chemotherapy. Our bioanalytical chemistry research has involved the development of novel methods for monitoring dynamic properties of peptides, proteins, lipids and DNA using capillary electrophoresis (CE), circular dichroism (CD), and nuclear magnetic resonance (NMR) spectroscopy. The molecular modeling/bioinformatics research area aims to expand the application of molecular mechanics techniques in order to model dynamic processes in the biopolymers we investigate.

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2002 - Present
Degree - University  
PhD, Chemistry & Biochemistry - University of California, Los Angeles

Worked with Profs Orville L. Chapman and Juli Feigon on Bioorganic and Biophysical Chemistry project for PhD Thesis

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1983 - 1989
BA, Chemistry & Biochemistry - Northwestern University

Undergraduate Research 2 years with Prof. Thomas Laffler, Med School
3 years with Prof. Robert L. Letsinger, Chemistry Department

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1979 - 1983
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