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Andre Dejam

Position - Company  
Research Fellow - Gerszten lab Beth Israel Deaconess Medical Center 2011 - Present
Degree - University  
MD, PhD, Medicine - University of Hannover, Germany 1994 - 2001
Publication Info
Metabolite profiling identifies pathways associated with metabolic risk in humans. Cheng S, Rhee EP, Larson MG, Lewis GD, McCabe EL, Shen D, Palma MJ and 12 others Circulation. 125(18):2222-31. doi: 10.1161/CIRCULATIONAHA.111.067827. May 8, 2012. View on PubMed.
Benefit of transferring ST-segment-elevation myocardial infarction patients for percutaneous coronary intervention compared with administration of onsite fibrinolytic declines as delays increase. Pinto DS, Frederick PD, Chakrabarti AK, Kirtane AJ, Ullman E, Dejam A, Miller DP, Henry TD, Gibson CM, National Registry of Myocardial Infarction Investigators Circulation. 124(23):2512-21. doi: 10.1161/CIRCULATIONAHA.111.018549. December 6, 2011. View on PubMed.
Repeated successful balloon valvuloplasty of a bioprosthetic aortic valve in a nonagenerian. Dejam A, Hokinson M, Laham R Catheter Cardiovasc Interv. 77(4):589-92. doi: 10.1002/ccd.22816. March 1, 2011. View on PubMed.
Characterization of erythrocytic uptake and release and disposition pathways of nitrite, nitrate, methemoglobin, and iron-nitrosyl hemoglobin in the human circulation. Hon YY, Sun H, Dejam A, Gladwin MT Drug Metab Dispos. 38(10):1707-13. doi: 10.1124/dmd.110.034355. July 15, 2010. View on PubMed.
Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation. Dejam A, Hunter CJ, Tremonti C, Pluta RM, Hon YY, Grimes G, Partovi K and 5 others Circulation. 116(16):1821-31. doi: 10.1161/CIRCULATIONAHA.107.712133. October 16, 2007. View on PubMed.
A novel method of measuring reduction of nitrite-induced methemoglobin applied to fetal and adult blood of humans and sheep. Power GG, Bragg SL, Oshiro BT, Dejam A, Hunter CJ, Blood AB J Appl Physiol. 103(4):1359-65. doi: 10.1152/japplphysiol.00443.2007. July 5, 2007. View on PubMed.
The reductase NCB5OR is responsive to the redox status in beta-cells and is not involved in the ER stress response. Larade K, Jiang ZG, Dejam A, Zhu H, Bunn HF Biochem J. 404(3):467-76. doi: 10.1042/BJ20061859. June 15, 2007. View on PubMed.
Recent methodological advances in the analysis of nitrite in the human circulation: nitrite as a biochemical parameter of the L-arginine/NO pathway. Grau M, Hendgen-Cotta UB, Brouzos P, Drexhage C, Rassaf T, Lauer T, Dejam A, Kelm M, Kleinbongard P J Chromatogr B Analyt Technol Biomed Life Sci. 851(1-2):106-23. doi: 10.1016/j.jchromb.2007.02.002. May 15, 2007. View on PubMed.
Effects of dietary nitrate on blood pressure. Dejam A, Hunter CJ, Gladwin MT N Engl J Med. 356(15):1590; author reply 1590. doi: 10.1056/NEJMc070163. April 12, 2007. View on PubMed.
Endothelial progenitor cell mobilization and increased intravascular nitric oxide in patients undergoing cardiac rehabilitation. Paul JD, Powell TM, Thompson M, Benjamin M, Rodrigo M, Carlow A, Annavajjhala V and 11 others J Cardiopulm Rehabil Prev. 27(2):65-73. doi: 10.1097/01.HCR.0000265031.10145.50. April 2007. View on PubMed.
The measurement of blood and plasma nitrite by chemiluminescence: pitfalls and solutions. Pelletier MM, Kleinbongard P, Ringwood L, Hito R, Hunter CJ, Schechter AN, Gladwin MT, Dejam A Free Radic Biol Med. 41(4):541-8. doi: 10.1016/j.freeradbiomed.2006.05.001. August 15, 2006. View on PubMed.
Lopinavir-ritonavir: effects on endothelial cell function in healthy subjects. Grubb JR, Dejam A, Voell J, Blackwelder WC, Sklar PA, Kovacs JA, Cannon RO, Masur H, Gladwin MT J Infect Dis. 193(11):1516-9. doi: 10.1086/503807. June 1, 2006. View on PubMed.
Red blood cells express a functional endothelial nitric oxide synthase. Kleinbongard P, Schulz R, Rassaf T, Lauer T, Dejam A, Jax T, Kumara I and 11 others Blood. 107(7):2943-51. doi: 10.1182/blood-2005-10-3992. April 1, 2006. View on PubMed.
Plasma nitroso compounds are decreased in patients with endothelial dysfunction. Heiss C, Lauer T, Dejam A, Kleinbongard P, Hamada S, Rassaf T, Matern S, Feelisch M, Kelm M J Am Coll Cardiol. 47(3):573-9. doi: 10.1016/j.jacc.2005.06.089. February 7, 2006. View on PubMed.
Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Kleinbongard P, Dejam A, Lauer T, Jax T, Kerber S, Gharini P, Balzer J and 6 others Free Radic Biol Med. 40(2):295-302. doi: 10.1016/j.freeradbiomed.2005.08.025. January 15, 2006. View on PubMed.
Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers. Heiss C, Kleinbongard P, Dejam A, Perré S, Schroeter H, Sies H, Kelm M J Am Coll Cardiol. 46(7):1276-83. doi: 10.1016/j.jacc.2005.06.055. October 4, 2005. View on PubMed.
Erythrocytes are the major intravascular storage sites of nitrite in human blood. Dejam A, Hunter CJ, Pelletier MM, Hsu LL, Machado RF, Shiva S, Power GG, Kelm M, Gladwin MT, Schechter AN Blood. 106(2):734-9. doi: 10.1182/blood-2005-02-0567. July 15, 2005. View on PubMed.
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. Duranski MR, Greer JJ, Dejam A, Jaganmohan S, Hogg N, Langston W, Patel RP and 5 others J Clin Invest. 115(5):1232-40. doi: 10.1172/JCI22493. April 14, 2005. View on PubMed.
Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage. Pluta RM, Dejam A, Grimes G, Gladwin MT, Oldfield EH JAMA. 293(12):1477-84. doi: 10.1001/jama.293.12.1477. March 23, 2005. View on PubMed.
Enzyme-independent nitric oxide formation during UVA challenge of human skin: characterization, molecular sources, and mechanisms. Paunel AN, Dejam A, Thelen S, Kirsch M, Horstjann M, Gharini P, Mürtz M and 4 others Free Radic Biol Med. 38(5):606-15. doi: 10.1016/j.freeradbiomed.2004.11.018. March 1, 2005. View on PubMed.
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Hunter CJ, Dejam A, Blood AB, Shields H, Kim-Shapiro DB, Machado RF, Tarekegn S and 5 others Nat Med. 10(10):1122-7. doi: 10.1038/nm1109. September 12, 2004. View on PubMed.
Biological activity of nitric oxide in the plasmatic compartment. Wang X, Tanus-Santos JE, Reiter CD, Dejam A, Shiva S, Smith RD, Hogg N, Gladwin MT Proc Natl Acad Sci U S A. 101(31):11477-82. doi: 10.1073/pnas.0402201101. August 3, 2004. View on PubMed.
Emerging role of nitrite in human biology. Dejam A, Hunter CJ, Schechter AN, Gladwin MT Blood Cells Mol Dis. 32(3):423-9. doi: 10.1016/j.bcmd.2004.02.002. June 2004. View on PubMed.
Thiols enhance NO formation from nitrate photolysis. Dejam A, Kleinbongard P, Rassaf T, Hamada S, Gharini P, Rodriguez J, Feelisch M, Kelm M Free Radic Biol Med. 35(12):1551-9. December 15, 2003. View on PubMed.
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Kleinbongard P, Dejam A, Lauer T, Rassaf T, Schindler A, Picker O, Scheeren T and 8 others Free Radic Biol Med. 35(7):790-6. October 1, 2003. View on PubMed.
Vascular effects of cocoa rich in flavan-3-ols. Heiss C, Dejam A, Kleinbongard P, Schewe T, Sies H, Kelm M JAMA. 290(8):1030-1. doi: 10.1001/jama.290.8.1030. August 27, 2003. View on PubMed.
Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human blood. Rassaf T, Kleinbongard P, Preik M, Dejam A, Gharini P, Lauer T, Erckenbrecht J and 5 others Circ Res. 91(6):470-7. September 20, 2002. View on PubMed.
Griess method for nitrite measurement of aqueous and protein-containing samples. Kleinbongard P, Rassaf T, Dejam A, Kerber S, Kelm M Methods Enzymol. 359:158-68. 2002. View on PubMed.
Impaired glucose tolerance, beta cell function and lipid metabolism in HIV patients under treatment with protease inhibitors. Behrens G, Dejam A, Schmidt H, Balks HJ, Brabant G, Körner T, Stoll M, Schmidt RE AIDS. 13(10):F63-70. July 9, 1999. View on PubMed.
Lipid evaluation in HIV-1-positive patients treated with protease inhibitors. Schmidt HH, Behrens G, Genschel J, Stoll M, Dejam A, Haas R, Manns MP, Schmidt RE Antivir Ther. 4(3):163-70. 1999. View on PubMed.
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