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Angel Garcia Martin

Lab Head - Regulation of Cell Growth Laboratory View Biosketch →

Position - Company  
Senior Researcher - Proteomika SL

Proteomics based biomarker discovery and assay development for cancer

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Mar 2006 - Dec 2006
Investigator - Cancer Genomics Lab Centro de Investigación Príncipe Felipe May 2005 - Dec 2005
Postdoctoral fellow - Apoptosis Section, Regulation of Cell Growth Lab National Cancer Institute (NIH) May 2000 - May 2005
PhD student - Centro de Biología Molecular Severo Ochoa (CBMSO – UAM) Jul 1994 - Dec 1999
Lab Head - Regulation of Cell Growth Laboratory Fundacion Inbiomed

Lead the gruop dedicated to studying breast cancer stem cell biology

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Mar 2007 - Present
Director - Inbiobank Fundacion Inbiomed

Biobank dedicated to banking adult stem cells for research.
Node of the National Stem Cell Bank
Member of Red de Biobancos, biobank network in Spain.

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Nov 2007 - Present
Degree - University  
Ph.D., Biochemistry and Molecular Biology - Universidad Autónoma de Madrid 1994 - 1999
BS , Biological Sciences - Universidad Autónoma de Madrid 1989 - 1994
Publication Info
Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells. Vazquez-Martin A, Vellon L, Quirós PM, Cufí S, Ruiz de Galarreta E, Oliveras-Ferraros C, Martin AG, Martin-Castillo B, López-Otín C, Menendez JA Cell Cycle. 11(5):. doi: 10.4161/cc.11.5.19450. March 1, 2012. View on PubMed.
(Stereotactic) radiosurgery XIX: spinal radiosurgery--two year experience in a UK centre. Martin AG, Cowley IR, Taylor BA, Cassoni AM, Landau DB, Plowman PN Br J Neurosurg. 26(1):53-8. doi: 10.3109/02688697.2011.603857. February 2012. View on PubMed.
Xenografts in zebrafish embryos as a rapid functional assay for breast cancer stem-like cell identification. Eguiara A, Holgado O, Beloqui I, Abalde L, Sanchez Y, Callol C, Martin AG Cell Cycle. 10(21):3751-7. doi: 10.4161/cc.10.21.17921. November 1, 2011. View on PubMed.
Sox2 expression in breast tumours and activation in breast cancer stem cells. Leis O, Eguiara A, Lopez-Arribillaga E, Alberdi MJ, Hernandez-Garcia S, Elorriaga K, Pandiella A, Rezola R, Martin AG Oncogene. :. doi: 10.1038/onc.2011.338. August 8, 2011. View on PubMed.
Using free text information to explore how and when GPs code a diagnosis of ovarian cancer: an observational study using primary care records of patients with ovarian cancer. Tate AR, Martin AG, Ali A, Cassell JA BMJ Open. 1(1):e000025. doi: 10.1136/bmjopen-2010-000025. February 23, 2011. View on PubMed.
Analysis of patient information leaflets provided by a district general hospital by the Flesch and Flesch-Kincaid method. Williamson JM, Martin AG Int J Clin Pract. 64(13):1824-31. doi: 10.1111/j.1742-1241.2010.02408.x. December 2010. View on PubMed.
Viability of Mycoplasma agalactiae and Mycoplasma mycoides subsp. capri in goat milk samples stored under different conditions. Amores J, Sánchez A, Martín AG, Corrales JC, Contreras A, de la Fe C Vet Microbiol. 145(3-4):347-50. doi: 10.1016/j.vetmic.2010.03.030. October 26, 2010. View on PubMed.
NFκB anti-apoptotic or pro-apoptotic, maybe both. Martin AG Cell Cycle. 9(16):3131-2. doi: 10.4161/cc.9.16.12780. August 15, 2010. View on PubMed.
[Clinical outcome of intermediate risk prostate cancer treated with iodine 125 monotherapy: The Hotel-Dieu of Quebec experience]. Zebentout O, Apardian R, Beaulieu L, Harel F, Martin AG, Vigneault E Cancer Radiother. 14(3):183-8. doi: 10.1016/j.canrad.2010.02.002. June 2010. View on PubMed.
p53-mediated induction of Noxa and p53AIP1 requires NFkappaB. O'Prey J, Crighton D, Martin AG, Vousden KH, Fearnhead HO, Ryan KM Cell Cycle. 9(5):947-52. doi: 10.4161/cc.9.5.10872. March 1, 2010. View on PubMed.
Assessing the readability statistics of national consent forms in the UK. Williamson JM, Martin AG Int J Clin Pract. 64(3):322-9. doi: 10.1111/j.1742-1241.2009.02245.x. February 2010. View on PubMed.
Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B. Martin AG, Trama J, Crighton D, Ryan KM, Fearnhead HO Aging (Albany NY). 1(3):335-49. doi: 10.18632/aging.100026. February 18, 2009. View on PubMed.
Differential regulation of p65 and c-Rel NF-kappaB transactivating activity by Cot, protein kinase C zeta and NIK protein kinases in CD3/CD28 activated T cells. Sánchez-Valdepeñas C, Punzón C, San-Antonio B, Martin AG, Fresno M Cell Signal. 19(3):528-37. doi: 10.1016/j.cellsig.2006.08.002. August 23, 2006. View on PubMed.
Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome. Chandra D, Bratton SB, Person MD, Tian Y, Martin AG, Ayres M, Fearnhead HO, Gandhi V, Tang DG Cell. 125(7):1333-46. doi: 10.1016/j.cell.2006.05.026. June 30, 2006. View on PubMed.
NF-kappaB-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity. Sánchez-Valdepeñas C, Martín AG, Ramakrishnan P, Wallach D, Fresno M J Immunol. 176(8):4666-74. April 15, 2006. View on PubMed.
Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis. Malet G, Martín AG, Orzáez M, Vicent MJ, Masip I, Sanclimens G, Ferrer-Montiel A and 4 others Cell Death Differ. 13(9):1523-32. doi: 10.1038/sj.cdd.4401828. December 9, 2005. View on PubMed.
Apo cytochrome c inhibits caspases by preventing apoptosome formation. Martin AG, Nguyen J, Wells JA, Fearnhead HO Biochem Biophys Res Commun. 319(3):944-50. doi: 10.1016/j.bbrc.2004.05.084. July 2, 2004. View on PubMed.
Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis. Martin AG, Fearnhead HO J Biol Chem. 277(52):50834-41. doi: 10.1074/jbc.M209369200. December 27, 2002. View on PubMed.
Regulation of nuclear factor kappa B transactivation. Implication of phosphatidylinositol 3-kinase and protein kinase C zeta in c-Rel activation by tumor necrosis factor alpha. Martin AG, San-Antonio B, Fresno M J Biol Chem. 276(19):15840-9. doi: 10.1074/jbc.M011313200. May 11, 2001. View on PubMed.
Tumor necrosis factor-alpha activation of NF-kappa B requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel. Martin AG, Fresno M J Biol Chem. 275(32):24383-91. doi: 10.1074/jbc.M909396199. August 11, 2000. View on PubMed.
Expression of IkappaBalpha in the nucleus of human peripheral blood T lymphocytes. Laín de Lera T, Folgueira L, Martín AG, Dargemont C, Pedraza MA, Bermejo M, Bonay P, Fresno M, Alcami J Oncogene. 18(8):1581-8. doi: 10.1038/sj.onc.1202455. February 25, 1999. View on PubMed.
Replication of human immunodeficiency virus-1 in primary human T cells is dependent on the autocrine secretion of tumor necrosis factor through the control of nuclear factor-kappa B activation. Muñoz-Fernández MA, Navarro J, Garcia A, Punzón C, Fernández-Cruz E, Fresno M J Allergy Clin Immunol. 100(6 Pt 1):838-45. December 1997. View on PubMed.
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