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Hari Raghu

Research specialist - Cancer Biology and Pharmacology View Biosketch →

Position - Company  
Research associate - Microbiology Immunology Chicago Medical School at Rosalind Franklin University of Medicine & Science

Interpret role of lipid rafts in KSHV entry and infection, as well as mechanism of KSHV entry in primary endothelial cells
Train graduate students in biochemical, virological and molecular biological techniques
Develop research studies in KSHV entry and infection
Regulate biochemical techniques, such as lipid raft isolation and immunoprecipitation
Adeptly utilize confocal microscopy and immune-fluorescence imaging techniques
Employ electron microscopy, flow cytometry and molecular biological techniques
Draft manuscripts and produce research leads for therapeutic strategies of Kaposi’s sarcoma treatment

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Jul 2005 - Jul 2008
Research associate - Jhaveri Microbiology Center LV Prasad Eye Institute

Examined viral etiology of congenital cataract
Evaluated efficiency of different diagnostic methodologies for ocular herpes virus diagnosis
Delivered research proposals for grant funding
Authored manuscripts and studied design for new research leads in ocular viral diseases
Trained and mentored junior graduate and postdoctoral students
Oversaw maintenance of standard operating procedures and routine laboratory procedures
Organized new diagnostic technologies for ocular viral infections

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Jan 2003 - Jul 2004
Lecturer in Immunology - Department of Biotechnology Mohamed Sathak College of Arts and Science

Teaching and training of post graduate students in Immunology
Design and formulate new experiments in Microbiology and Immunology
Evaluate students through assignments, examinations and lab exercises

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Aug 2000 - Jan 2003
Manager ( R&D) - Research and Development Bharat Immunologicals and Biologicals Corporation Limited

Design and Development of a prototype plasma derived vaccine for Hepatitis B

Training on Hepatitis B virus antigen purification at the Centers for Disease Control and Prevention. Atlanta, GA USA.

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Jan 1994 - May 2000
Research specialist - Cancer Biology and Pharmacology University of Illinois College of Medicine 2008 - Present
Degree - University  
Ph.D., Microbiology, virology - University of Madras 1995 - 2002
MS, Medical Microbiology, Anatomy, Physiology, Biochemistry, - University of Madras 1989 - 1992
BS, Botany, zoology and Chemistry - University of Madras 1986 - 1989
Publication Info
uPA and uPAR shRNA inhibit angiogenesis via enhanced secretion of SVEGFR1 independent of GM-CSF but dependent on TIMP-1 in endothelial and glioblastoma cells. Raghu H, Nalla AK, Gondi CS, Gujrati M, Dinh DH, Rao JS Mol Oncol. 6(1):33-47. doi: 10.1016/j.molonc.2011.11.008. February 2012. View on PubMed.
Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor. Raghu H, Gondi CS, Dinh DH, Gujrati M, Rao JS Mol Cancer. 10:130. doi: 10.1186/1476-4598-10-130. October 17, 2011. View on PubMed.
Targeting the coagulation factor fibrinogen for arthritis therapy. Raghu H, Flick MJ Curr Pharm Biotechnol. 12(9):1497-506. September 2011. View on PubMed.
Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells. Rao Malla R, Raghu H, Rao JS Int J Oncol. 37(6):1483-93. December 2010. View on PubMed.
Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells. Raghu H, Sodadasu PK, Malla RR, Gondi CS, Estes N, Rao JS BMC Cancer. 10:647. doi: 10.1186/1471-2407-10-647. November 24, 2010. View on PubMed.
Suppression of uPA and uPAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines. Raghu H, Lakka SS, Gondi CS, Mohanam S, Dinh DH, Gujrati M, Rao JS PLoS One. 5(8):e12458. doi: 10.1371/journal.pone.0012458. August 27, 2010. View on PubMed.
Kaposi's sarcoma-associated herpesvirus utilizes an actin polymerization-dependent macropinocytic pathway to enter human dermal microvascular endothelial and human umbilical vein endothelial cells. Raghu H, Sharma-Walia N, Veettil MV, Sadagopan S, Chandran B J Virol. 83(10):4895-911. doi: 10.1128/JVI.02498-08. March 11, 2009. View on PubMed.
Kaposi's sarcoma-associated herpesvirus forms a multimolecular complex of integrins (alphaVbeta5, alphaVbeta3, and alpha3beta1) and CD98-xCT during infection of human dermal microvascular endothelial cells, and CD98-xCT is essential for the postentry stag Veettil MV, Sadagopan S, Sharma-Walia N, Wang FZ, Raghu H, Varga L, Chandran B J Virol. 82(24):12126-44. doi: 10.1128/JVI.01146-08. December 2008. View on PubMed.
Alpha-fetoprotein as a tumor marker in hepatocellular carcinoma: investigations in south Indian subjects with hepatotropic virus and aflatoxin etiologies. Murugavel KG, Mathews S, Jayanthi V, Shankar EM, Hari R, Surendran R, Vengatesan A and 7 others Int J Infect Dis. 12(6):e71-6. doi: 10.1016/j.ijid.2008.04.010. July 26, 2008. View on PubMed.
Kaposi's sarcoma-associated herpesvirus induces sustained levels of vascular endothelial growth factors A and C early during in vitro infection of human microvascular dermal endothelial cells: biological implications. Sivakumar R, Sharma-Walia N, Raghu H, Veettil MV, Sadagopan S, Bottero V, Varga L, Levine R, Chandran B J Virol. 82(4):1759-76. doi: 10.1128/JVI.00873-07. December 5, 2007. View on PubMed.
Lipid rafts of primary endothelial cells are essential for Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8-induced phosphatidylinositol 3-kinase and RhoA-GTPases critical for microtubule dynamics and nuclear delivery of viral DNA but dispensab Raghu H, Sharma-Walia N, Veettil MV, Sadagopan S, Caballero A, Sivakumar R, Varga L, Bottero V, Chandran B J Virol. 81(15):7941-59. doi: 10.1128/JVI.02848-06. May 16, 2007. View on PubMed.
Kaposi's sarcoma-associated herpesvirus induces sustained NF-kappaB activation during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expression. Sadagopan S, Sharma-Walia N, Veettil MV, Raghu H, Sivakumar R, Bottero V, Chandran B J Virol. 81(8):3949-68. doi: 10.1128/JVI.02333-06. February 7, 2007. View on PubMed.
RhoA-GTPase facilitates entry of Kaposi's sarcoma-associated herpesvirus into adherent target cells in a Src-dependent manner. Veettil MV, Sharma-Walia N, Sadagopan S, Raghu H, Sivakumar R, Naranatt PP, Chandran B J Virol. 80(23):11432-46. doi: 10.1128/JVI.01342-06. September 27, 2006. View on PubMed.
Cyclooxygenase 2 induced by Kaposi's sarcoma-associated herpesvirus early during in vitro infection of target cells plays a role in the maintenance of latent viral gene expression. Sharma-Walia N, Raghu H, Sadagopan S, Sivakumar R, Veettil MV, Naranatt PP, Smith MM, Chandran B J Virol. 80(13):6534-52. doi: 10.1128/JVI.00231-06. July 2006. View on PubMed.
Herpes simplex virus-1--associated congenital cataract. Raghu H, Subhan S, Jose RJ, Gangopadhyay N, Bhende J, Sharma S Am J Ophthalmol. 138(2):313-4. doi: 10.1016/j.ajo.2004.03.010. August 2004. View on PubMed.
Evaluation of immunogenicity and safety of Genevac B: a new recombinant hepatitis B vaccine in comparison with Engerix B and Shanvac B in healthy adults. Vijayakumar V, Hari R, Parthiban R, Mehta J, Thyagarajan SP Indian J Med Microbiol. 22(1):34-8. March 2004. View on PubMed.
Chlamydia trachomatis genital infection in apparently healthy adult population of Tamil Nadu, India: a population-based study. Joyee AG, Thyagarajan SP, Rajendran P, Hari R, Balakrishnan P, Jeyaseelan L, Kurien T, STD Study Group Int J STD AIDS. 15(1):51-5. doi: 10.1258/095646204322637272. January 2004. View on PubMed.
Serodiagnosis of syphilis in a community: an evaluatory study. Rajendran P, Thyagarajan SP, Pramod NP, Joyee AG, Murugavel KG, Balakrishnan P, Hari R, Jeyaseelan L, Kurien T, STD study group Indian J Med Microbiol. 21(3):179-83. September 2003. View on PubMed.
Herbal medicines for liver diseases in India. Thyagarajan SP, Jayaram S, Gopalakrishnan V, Hari R, Jeyakumar P, Sripathi MS J Gastroenterol Hepatol. 17 Suppl 3:S370-6. December 2002. View on PubMed.
Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae genital infections in the apparently healthy population of Sringeri (Karnataka) by a coamplification PCR assay. Sowmya B, Rajendran P, Krishnan S, Joyee AG, Hari R, Rajesh PK, Thyagarajan SP, Ramkumar Indian J Med Microbiol. 19(4):228-9. December 2001. View on PubMed.
Asymptomatic malarial parasitaemia in Tamil Nadu. Rajendran P, Rajesh PK, Thyagarajan SP, Balakrishnan P, Hari R, Joyee AG, Kurien T, Krishnmurthy P, Jacob V, STD Study Group J Assoc Physicians India. 49:1161-4. December 2001. View on PubMed.
Influence of human immunodeficiency virus status on the clinical history of herpes simplex keratitis. Pramod NP, Hari R, Sudhamathi K, Ananadakannan K, Thyagarajan SP Ophthalmologica. 214(5):337-40. doi: 10.1159/000027516. October 2000. View on PubMed.
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