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Ramon Garcia Escudero

Staff Research Scientist - CIEMAT View Biosketch →

Position - Company  
Marie-Curie Postdoctoral fellow - Cancer Research Uk

Oncogenic activities of E6 and E7 genes of human papillomaviruses

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Aug 2001 - Feb 2004
Postdoctoral fellow - Centro de Biología Molecular Severo Ochoa (CBMSO – UAM)

Functional analysis of African swine fever virus genes: cellular trafficking, DNA repair, viral gene promoter mapping

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Jul 1996 - Jul 2001
Ph.D. student - Centro de Biología Molecular Severo Ochoa (CBMSO – UAM)

Genetic manipulation of African swine fever virus. Inducible gene expression of viral genes

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Jan 1992 - Jun 1996
Staff Research Scientist - Epithelial Biomedicine Division Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas

CIEMAT is a Spanish Government Scientific Institute. Our division is specialized in epithelial biologya nd pathologies, such as cancer. I'm interested in molecular oncology with the aim to find new therapeutic solutions for cancer patients. My research is focused in mouse models of cancer and genomic technologies. I'm an expert in microarray data analysis for miRNA, gene expression and genome structure.

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Jan 2009 - Present
Staff Research Scientist - CIEMAT

- I am leading high-throughput genomic research within the Basic Research Department at CIEMAT, supervising and performing microarray-based data analyses.
- I am leading research involving the oncogenic activities of human papillomaviruses (HPVs) and cancer, and setting-up new experimental models for HPV-related therapies

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Feb 2004 - Present
Degree - University  
Ph.D., Molecular Biology - Universidad Autónoma de Madrid 1992 - 1996
Ph.D., Molecular Biology - Universidad Autónoma de Madrid 1992 - 1996
Bachelor, Biology - Universidad Autónoma de Madrid 1987 - 1991
BS, Biology - Universidad Autónoma de Madrid 1986 - 1991
Publication Info
Cell fusion reprogramming leads to a specific hepatic expression pattern during mouse bone marrow derived hepatocyte formation in vivo. Quintana-Bustamante O, Grueso E, Garcia-Escudero R, Arza E, Alvarez-Barrientos A, Fabregat I, Garcia-Bravo M, Meza NW, Segovia JC PLoS One. 7(3):e33945. doi: 10.1371/journal.pone.0033945. March 23, 2012. View on PubMed.
Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts. García-Hoz C, Sánchez-Fernández G, García-Escudero R, Fernández-Velasco M, Palacios-García J, Ruiz-Meana M, Díaz-Meco MT and 6 others J Biol Chem. 287(10):7792-802. doi: 10.1074/jbc.M111.282210. March 2, 2012. View on PubMed.
p27(Kip1) represses transcription by direct interaction with p130/E2F4 at the promoters of target genes. Pippa R, Espinosa L, Gundem G, García-Escudero R, Dominguez A, Orlando S, Gallastegui E and 7 others Oncogene. :. doi: 10.1038/onc.2011.582. December 19, 2011. View on PubMed.
The E2 protein of human papillomavirus type 8 increases the expression of matrix metalloproteinase-9 in human keratinocytes and organotypic skin cultures. Akgül B, García-Escudero R, Ekechi C, Steger G, Navsaria H, Pfister H, Storey A Med Microbiol Immunol. 200(2):127-35. doi: 10.1007/s00430-011-0183-4. January 28, 2011. View on PubMed.
Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy. García-Escudero R, Martínez-Cruz AB, Santos M, Lorz C, Segrelles C, Garaulet G, Saiz-Ladera C and 4 others Mol Cancer. 9:193. doi: 10.1186/1476-4598-9-193. July 14, 2010. View on PubMed.
A functional role of RB-dependent pathway in the control of quiescence in adult epidermal stem cells revealed by genomic profiling. Lorz C, García-Escudero R, Segrelles C, Garín MI, Ariza JM, Santos M, Ruiz S and 7 others Stem Cell Rev. 6(2):162-77. doi: 10.1007/s12015-010-9139-0. June 2010. View on PubMed.
Gene expression profiling of mouse epidermal keratinocytes. García-Escudero R, Paramio JM Methods Mol Biol. 585:171-81. doi: 10.1007/978-1-60761-380-0_13. 2010. View on PubMed.
Transgenic mice expressing constitutively active Akt in oral epithelium validate KLFA as a potential biomarker of head and neck squamous cell carcinoma. Moral M, Segrelles C, Martínez-Cruz AB, Lorz C, Santos M, García-Escudero R, Lu J and 11 others In Vivo. 23(5):653-60. October 2009. View on PubMed.
Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammation. Martínez-Cruz AB, Santos M, García-Escudero R, Moral M, Segrelles C, Lorz C, Saiz C, Buitrago-Pérez A, Costa C, Paramio JM Anticancer Res. 29(8):3035-42. August 2009. View on PubMed.
Molecular Signature of HPV-Induced Carcinogenesis: pRb, p53 and Gene Expression Profiling. Buitrago-Pérez A, Garaulet G, Vázquez-Carballo A, Paramio JM, García-Escudero R Curr Genomics. 10(1):26-34. doi: 10.2174/138920209787581235. March 2009. View on PubMed.
Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma. Moral M, Segrelles C, Lara MF, Martínez-Cruz AB, Lorz C, Santos M, García-Escudero R and 14 others Cancer Res. 69(3):1099-108. doi: 10.1158/0008-5472.CAN-08-3240. February 1, 2009. View on PubMed.
Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage. Santos M, Ruiz S, Lara MF, Segrelles C, Moral M, Martínez-Cruz AB, Ballestín C, Lorz C, García-Escudero R, Paramio JM Mol Carcinog. 47(11):815-21. doi: 10.1002/mc.20426. November 2008. View on PubMed.
Gene expression profiling as a tool for basic analysis and clinical application of human cancer. García-Escudero R, Paramio JM Mol Carcinog. 47(8):573-9. doi: 10.1002/mc.20430. August 2008. View on PubMed.
Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis. Lara MF, García-Escudero R, Ruiz S, Santos M, Moral M, Martínez-Cruz AB, Segrelles C, Lorz C, Paramio JM Mol Carcinog. 47(3):209-21. doi: 10.1002/mc.20376. March 2008. View on PubMed.
Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors. Martínez-Cruz AB, Santos M, Lara MF, Segrelles C, Ruiz S, Moral M, Lorz C, García-Escudero R, Paramio JM Cancer Res. 68(3):683-92. doi: 10.1158/0008-5472.CAN-07-3049. February 1, 2008. View on PubMed.
p107 acts as a tumor suppressor in pRb-deficient epidermis. Lara MF, Santos M, Ruiz S, Segrelles C, Moral M, Martínez-Cruz AB, Hernández P and 4 others Mol Carcinog. 47(2):105-13. doi: 10.1002/mc.20367. February 2008. View on PubMed.
Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis. Segrelles C, Lu J, Hammann B, Santos M, Moral M, Cascallana JL, Lara MF and 11 others Cancer Res. 67(22):10879-88. doi: 10.1158/0008-5472.CAN-07-2564. November 15, 2007. View on PubMed.
Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling. Segrelles C, Moral M, Lorz C, Santos M, Lu J, Cascallana JL, Lara MF and 8 others Mol Biol Cell. 19(1):137-49. doi: 10.1091/mbc.E07-08-0764. October 24, 2007. View on PubMed.
Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria. Leverrier S, Bergamaschi D, Ghali L, Ola A, Warnes G, Akgül B, Blight K and 4 others Apoptosis. 12(3):549-60. doi: 10.1007/s10495-006-0004-1. December 31, 2006. View on PubMed.
African swine fever virus protein pE296R is a DNA repair apurinic/apyrimidinic endonuclease required for virus growth in swine macrophages. Redrejo-Rodríguez M, García-Escudero R, Yáñez-Muñoz RJ, Salas ML, Salas J J Virol. 80(10):4847-57. doi: 10.1128/JVI.80.10.4847-4857.2006. May 2006. View on PubMed.
Molecular determinants of Akt-induced keratinocyte transformation. Segrelles C, Moral M, Lara MF, Ruiz S, Santos M, Leis H, García-Escudero R and 5 others Oncogene. 25(8):1174-85. doi: 10.1038/sj.onc.1209155. February 23, 2006. View on PubMed.
The E7 protein of cutaneous human papillomavirus type 8 causes invasion of human keratinocytes into the dermis in organotypic cultures of skin. Akgül B, García-Escudero R, Ghali L, Pfister HJ, Fuchs PG, Navsaria H, Storey A Cancer Res. 65(6):2216-23. doi: 10.1158/0008-5472.CAN-04-1952. March 15, 2005. View on PubMed.
UV-B irradiation stimulates the promoter activity of the high-risk, cutaneous human papillomavirus 5 and 8 in primary keratinocytes. Akgül B, Lemme W, García-Escudero R, Storey A, Pfister HJ Arch Virol. 150(1):145-51. doi: 10.1007/s00705-004-0398-4. October 5, 2004. View on PubMed.
Human papillomavirus type 77 E6 protein selectively inhibits p53-dependent transcription of proapoptotic genes following UV-B irradiation. Giampieri S, García-Escudero R, Green J, Storey A Oncogene. 23(34):5864-70. doi: 10.1038/sj.onc.1207711. July 29, 2004. View on PubMed.
African swine fever virus structural protein p54 is essential for the recruitment of envelope precursors to assembly sites. Rodríguez JM, García-Escudero R, Salas ML, Andrés G J Virol. 78(8):4299-1313. April 2004. View on PubMed.
DNA polymerase X of African swine fever virus: insertion fidelity on gapped DNA substrates and AP lyase activity support a role in base excision repair of viral DNA. García-Escudero R, García-Díaz M, Salas ML, Blanco L, Salas J J Mol Biol. 326(5):1403-12. March 7, 2003. View on PubMed.
Repression of African swine fever virus polyprotein pp220-encoding gene leads to the assembly of icosahedral core-less particles. Andrés G, García-Escudero R, Salas ML, Rodríguez JM J Virol. 76(6):2654-66. March 2002. View on PubMed.
African swine fever virus structural protein pE120R is essential for virus transport from assembly sites to plasma membrane but not for infectivity. Andrés G, García-Escudero R, Viñuela E, Salas ML, Rodríguez JM J Virol. 75(15):6758-68. doi: 10.1128/JVI.75.15.6758-6768.2001. August 2001. View on PubMed.
Structure of African swine fever virus late promoters: requirement of a TATA sequence at the initiation region. García-Escudero R, Viñuela E J Virol. 74(17):8176-82. September 2000. View on PubMed.
African swine fever virus dUTPase is a highly specific enzyme required for efficient replication in swine macrophages. Oliveros M, García-Escudero R, Alejo A, Viñuela E, Salas ML, Salas J J Virol. 73(11):8934-43. November 1999. View on PubMed.
African swine fever virus is enveloped by a two-membraned collapsed cisterna derived from the endoplasmic reticulum. Andrés G, García-Escudero R, Simón-Mateo C, Viñuela E J Virol. 72(11):8988-9001. November 1998. View on PubMed.
Inducible gene expression from African swine fever virus recombinants: analysis of the major capsid protein p72. García-Escudero R, Andrés G, Almazán F, Viñuela E J Virol. 72(4):3185-95. April 1998. View on PubMed.
The structural protein p54 is essential for African swine fever virus viability. Rodriguez F, Ley V, Gómez-Puertas P, García R, Rodriguez JF, Escribano JM Virus Res. 40(2):161-7. February 1996. View on PubMed.
Vectors for the genetic manipulation of African swine fever virus. García R, Almazán F, Rodríguez JM, Alonso M, Viñuela E, Rodríguez JF J Biotechnol. 40(2):121-31. June 1, 1995. View on PubMed.
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