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Judith Lacoste

CEO/CSO - MIA Cellavie Inc
Montreal Quebec, CA
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Position - Company  
Microscopy specialist - McGill University

Working in the Cell Imaging & Analysis Network (CIAN) of the biology department to:
-Provide education in microscopy.
-Advice users about various microscopy techniques.
-Train users to use microscopy systems for their research projects.
-Maintain microscopy systems in optimal conditions.
-Assist users in microscopy image acquisition and analysis.

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Oct 2006 - Mar 2013
Research Associate - Lady Davis Institute for Medical Research

Basic research on innate immunity.

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Jul 2005 - Oct 2006
Research Associate - MUHC Research Institute

Medical research on prostate cancer.

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Oct 2000 - Jul 2005
Post-doctoral fellowship - McGill University

Basic research on cell motility.

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Jul 1998 - Oct 2000
Post-doctoral fellowship - University of Virginia

Basic research in cell motility.

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Oct 1994 - Jul 1998
CEO/CSO - MIA Cellavie Inc

Consulting expert services in microscopy, imaging and analysis (life sciences) with MIA Cellavie Inc., offering an integrated approach to microscopy.
Microscopy is an essential technology for most life science researchers and they usually love to present and publish beautiful microscopy data. It is also true that despite a common feeling that microscopy is not very complicated, many scientists actually struggle with it. While modern microscopy systems are indeed sophisticated equipments, it is useful to first consider microscopy as being composed of three simple elements: operator, equipment and sample. Keeping such a vision in mind can help the process of acquiring robust data by microscopy. Microscopy goes beyond pretty pictures and provides strong scientific answers when it is performed in an artefact-free, reproducible and quantitative manner.

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Feb 2006 - Present
Degree - University  
Ph.D., Microbiology & Immunology - McGill University 1989 - 1995
B.Sc., Microbiology & Immunology - McGill University 1986 - 1989
Publication Info
RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. Solis M, Nakhaei P, Jalalirad M, Lacoste J, Douville R, Arguello M, Zhao T, Laughrea M, Wainberg MA, Hiscott J J Virol. 85(3):1224-36. doi: 10.1128/JVI.01635-10. November 17, 2010. View on PubMed.
Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter. Paz S, Vilasco M, Arguello M, Sun Q, Lacoste J, Nguyen TL, Zhao T and 7 others Mol Cell Biol. 29(12):3401-12. doi: 10.1128/MCB.00880-08. April 20, 2009. View on PubMed.
Live-cell microscopy - tips and tools. Frigault MM, Lacoste J, Swift JL, Brown CM J Cell Sci. 122(Pt 6):753-67. doi: 10.1242/jcs.033837. March 15, 2009. View on PubMed.
Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease. Hiscott J, Lacoste J, Lin R Biochem Pharmacol. 72(11):1477-84. doi: 10.1016/j.bcp.2006.06.030. November 30, 2006. View on PubMed.
Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage. Lin R, Lacoste J, Nakhaei P, Sun Q, Yang L, Paz S, Wilkinson P and 4 others J Virol. 80(12):6072-83. doi: 10.1128/JVI.02495-05. June 2006. View on PubMed.
Focal adhesion kinase is required for bombesin-induced prostate cancer cell motility. Lacoste J, Aprikian AG, Chevalier S Mol Cell Endocrinol. 235(1-2):51-61. doi: 10.1016/j.mce.2004.06.014. May 12, 2005. View on PubMed.
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