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Kaushik Dutta

Senior Scientist - New York Structural Biology Center View Biosketch →

Position - Company  
Senior Scientist - New York Structural Biology Center

My research is mainly focused on using diverse NMR methods to investigate structure-function relationships in proteins, nucleic acids and their complexes. During the past few years I have been involved in several collaborative projects with investigators from various New York area and abroad universities. These projects have yielded novel structures, interesting dynamics and key interactions that have furthered the understanding of the function of these biological systems.

I like to be a consultant to projects which are involved in structural biology for academic and private sector.


Show details
Oct 2002 - Present
Degree - University  
Ph.D, Chemistry - Indian Institute of Technology, Delhi 1992 - 1997
Publication Info
Solution structure and DNA-binding properties of the phosphoesterase domain of DNA ligase D. Natarajan A, Dutta K, Temel DB, Nair PA, Shuman S, Ghose R Nucleic Acids Res. 40(5):2076-88. doi: 10.1093/nar/gkr950. March 2012. View on PubMed.
The alternatively spliced acid box region plays a key role in FGF receptor autoinhibition. Kalinina J, Dutta K, Ilghari D, Beenken A, Goetz R, Eliseenkova AV, Cowburn D, Mohammadi M Structure. 20(1):77-88. doi: 10.1016/j.str.2011.10.022. January 11, 2012. View on PubMed.
Sequence-specific 1H, 13C and 15N assignments of the phosphoesterase (PE) domain of Pseudomonas aeruginosa DNA ligase D (LigD). Dutta K, Natarajan A, Nair PA, Shuman S, Ghose R Biomol NMR Assign. 5(2):151-5. doi: 10.1007/s12104-010-9289-7. October 2011. View on PubMed.
Probing the self-association, intermolecular contacts, and folding propensity of amelogenin. Ndao M, Dutta K, Bromley KM, Lakshminarayanan R, Sun Z, Rewari G, Moradian-Oldak J, Evans JS Protein Sci. 20(4):724-34. doi: 10.1002/pro.603. April 2011. View on PubMed.
Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock. Varshney AK, Wang X, Cook E, Dutta K, Scharff MD, Goger MJ, Fries BC J Biol Chem. 286(11):9737-47. doi: 10.1074/jbc.M110.212407. March 18, 2011. View on PubMed.
Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E. Tait S, Dutta K, Cowburn D, Warwicker J, Doig AJ, McCarthy JE Proc Natl Acad Sci U S A. 107(41):17627-32. doi: 10.1073/pnas.1008242107. October 12, 2010. View on PubMed.
Two-state conformational equilibrium in the Par-4 leucine zipper domain. Schwalbe M, Dutta K, Libich DS, Venugopal H, Claridge JK, Gell DA, Mackay JP, Edwards PJ, Pascal SM Proteins. 78(11):2433-49. doi: 10.1002/prot.22752. August 15, 2010. View on PubMed.
Structural determination of biomolecular interfaces by nuclear magnetic resonance of proteins with reduced proton density. Ferrage F, Dutta K, Shekhtman A, Cowburn D J Biomol NMR. 47(1):41-54. doi: 10.1007/s10858-010-9409-9. May 2010. View on PubMed.
Intrinsic disorder and coiled-coil formation in prostate apoptosis response factor 4. Libich DS, Schwalbe M, Kate S, Venugopal H, Claridge JK, Edwards PJ, Dutta K, Pascal SM FEBS J. 276(14):3710-28. doi: 10.1111/j.1742-4658.2009.07087.x. July 2009. View on PubMed.
A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding. Schwartz EC, Shekhtman A, Dutta K, Pratt MR, Cowburn D, Darst S, Muir TW Chem Biol. 15(10):1091-103. doi: 10.1016/j.chembiol.2008.09.008. October 20, 2008. View on PubMed.
Structure and dynamics of the P7 protein from the bacteriophage phi 12. Eryilmaz E, Benach J, Su M, Seetharaman J, Dutta K, Wei H, Gottlieb P, Hunt JF, Ghose R J Mol Biol. 382(2):402-22. doi: 10.1016/j.jmb.2008.07.006. October 3, 2008. View on PubMed.
15N relaxation studies of Apo-Mts1: a dynamic S100 protein. Dutta K, Cox CJ, Basavappa R, Pascal SM Biochemistry. 47(29):7637-47. doi: 10.1021/bi8005048. July 22, 2008. View on PubMed.
N-terminal cysteinyl proteins can be prepared using thrombin cleavage. Liu D, Xu R, Dutta K, Cowburn D FEBS Lett. 582(7):1163-7. doi: 10.1016/j.febslet.2008.02.078. April 2, 2008. View on PubMed.
NMR structure of stem-loop D from human rhinovirus-14. Headey SJ, Huang H, Claridge JK, Soares GA, Dutta K, Schwalbe M, Yang D, Pascal SM RNA. 13(3):351-60. doi: 10.1261/rna.313707. March 2007. View on PubMed.
Solution structure and dynamics of the N-terminal cytosolic domain of rhomboid intramembrane protease from Pseudomonas aeruginosa: insights into a functional role in intramembrane proteolysis. Del Rio A, Dutta K, Chavez J, Ubarretxena-Belandia I, Ghose R J Mol Biol. 365(1):109-22. doi: 10.1016/j.jmb.2006.09.047. January 5, 2007. View on PubMed.
Solution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II. Muralidharan V, Dutta K, Cho J, Vila-Perello M, Raleigh DP, Cowburn D, Muir TW Biochemistry. 45(29):8874-84. doi: 10.1021/bi060590z. July 25, 2006. View on PubMed.
NMR solution structure and backbone dynamics of domain III of the E protein of tick-borne Langat flavivirus suggests a potential site for molecular recognition. Mukherjee M, Dutta K, White MA, Cowburn D, Fox RO Protein Sci. 15(6):1342-55. doi: 10.1110/ps.051844006. June 2006. View on PubMed.
Mapping structural interactions using in-cell NMR spectroscopy (STINT-NMR). Burz DS, Dutta K, Cowburn D, Shekhtman A Nat Methods. 3(2):91-3. doi: 10.1038/nmeth851. February 2006. View on PubMed.
In-cell NMR for protein-protein interactions (STINT-NMR). Burz DS, Dutta K, Cowburn D, Shekhtman A Nat Protoc. 1(1):146-52. doi: 10.1038/nprot.2006.23. 2006. View on PubMed.
Backbone and side chain resonance assignments of domain III of the tick-borne Langat flavivirus envelope protein. Mukherjee M, Dutta K, Pascal SM, Fox RO J Biomol NMR. 29(4):535-6. doi: 10.1023/B:JNMR.0000034345.94232.16. August 2004. View on PubMed.
Dynamic influences on a high-affinity, high-specificity interaction involving the C-terminal SH3 domain of p67phox. Dutta K, Shi H, Cruz-Chu ER, Kami K, Ghose R Biochemistry. 43(25):8094-106. doi: 10.1021/bi030268d. June 29, 2004. View on PubMed.
Stabilization of a pH-sensitive apoptosis-linked coiled coil through single point mutations. Dutta K, Engler FA, Cotton L, Alexandrov A, Bedi GS, Colquhoun J, Pascal SM Protein Sci. 12(2):257-65. doi: 10.1110/ps.0223903. February 2003. View on PubMed.
The regions of securin and cyclin B proteins recognized by the ubiquitination machinery are natively unfolded. Cox CJ, Dutta K, Petri ET, Hwang WC, Lin Y, Pascal SM, Basavappa R FEBS Lett. 527(1-3):303-8. September 11, 2002. View on PubMed.
Sequence-specific chemical shift assignment of calcium-loaded murine S100A4. Cox CJ, Dutta K, Basavappa R, Zain SB, Pascal SM J Biomol NMR. 23(2):153-4. June 2002. View on PubMed.
Calcium coordination studies of the metastatic Mts1 protein. Dutta K, Cox CJ, Huang H, Basavappa R, Pascal SM Biochemistry. 41(13):4239-45. April 2, 2002. View on PubMed.
Sequence-specific chemical shift assignment and chemical shift indexing of murine apo-Mts1. Dutta K, Cox CJ, Alexandrov A, Huang H, Basavappa R, Pascal SM J Biomol NMR. 22(2):181-2. February 2002. View on PubMed.
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