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Manuel Mameli

Group Leader - Institut du Fer a Moulin

Position - Company  
PhD students, Postdoctoral Fellow - Department of Basic Neuroscience University of Geneva Jan 2006 - Aug 2010
Research Fellow - Department of Neuroscience University of New Mexico Oct 2002 - Dec 2005
Group Leader - Institut du Fer a Moulin INSERM, Institut du Fer a Moulin

Electrophysiology in vitro
Patch-Clamp
Synaptic transmission
Syanptic plasticity
Reward system
Addiction
Optogenetics

Show details
Sep 2010 - Present
Degree - University  
PhD, Neuroscience - University of Geneva 2006 - 2009
Publication Info
The context of clinical research and its ethical relevance: the COMPAS trial as a case study. Camporesi S, Mameli M Am J Bioeth. 12(1):39-40. doi: 10.1080/15265161.2011.635836. 2012. View on PubMed.
Neuroscience. Synaptic switch and social status. Maroteaux M, Mameli M Science. 334(6056):608-9. doi: 10.1126/science.1214713. November 4, 2011. View on PubMed.
In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA. Bellone C, Mameli M, Lüscher C Nat Neurosci. 14(11):1439-46. doi: 10.1038/nn.2930. October 2, 2011. View on PubMed.
Cystic fibrosis carrier screening in Veneto (Italy): an ethical analysis. Bruni T, Mameli M, Pravettoni G, Boniolo G Med Health Care Philos. :. doi: 10.1007/s11019-011-9347-7. August 24, 2011. View on PubMed.
Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area. Mameli M, Bellone C, Brown MT, Lüscher C Nat Neurosci. 14(4):414-6. doi: 10.1038/nn.2763. February 20, 2011. View on PubMed.
An evaluation of the concept of innateness. Mameli M, Bateson P Philos Trans R Soc Lond B Biol Sci. 366(1563):436-43. doi: 10.1098/rstb.2010.0174. February 12, 2011. View on PubMed.
Synaptic plasticity and addiction: Learning mechanisms gone awry. Mameli M, Lüscher C Neuropharmacology. :. doi: 10.1016/j.neuropharm.2011.01.036. January 28, 2011. View on PubMed.
Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. Brown MT, Bellone C, Mameli M, Labouèbe G, Bocklisch C, Balland B, Dahan L, Luján R, Deisseroth K, Lüscher C PLoS One. 5(12):e15870. doi: 10.1371/journal.pone.0015870. December 31, 2010. View on PubMed.
Hg2+ detection by new anthracene pendant-arm derivatives of mixed N/S- and N/S/O-donor macrocycles: fluorescence, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and density functional theory studies. Mameli M, Lippolis V, Caltagirone C, Capelo JL, Faza ON, Lodeiro C Inorg Chem. 49(18):8276-86. doi: 10.1021/ic1007439. September 20, 2010. View on PubMed.
Moral responsibility and mental illness: a case study. Broome MR, Bortolotti L, Mameli M Camb Q Healthc Ethics. 19(2):179-87. doi: 10.1017/S0963180109990442. April 2010. View on PubMed.
Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Mameli M, Halbout B, Creton C, Engblom D, Parkitna JR, Spanagel R, Lüscher C Nat Neurosci. 12(8):1036-41. doi: 10.1038/nn.2367. July 13, 2009. View on PubMed.
Mechanisms of synaptic depression triggered by metabotropic glutamate receptors. Bellone C, Lüscher C, Mameli M Cell Mol Life Sci. 65(18):2913-23. doi: 10.1007/s00018-008-8263-3. September 2008. View on PubMed.
Ethanol decreases Purkinje neuron excitability by increasing GABA release in rat cerebellar slices. Mameli M, Botta P, Zamudio PA, Zucca S, Valenzuela CF J Pharmacol Exp Ther. 327(3):910-7. doi: 10.1124/jpet.108.144865. August 28, 2008. View on PubMed.
Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Engblom D, Bilbao A, Sanchis-Segura C, Dahan L, Perreau-Lenz S, Balland B, Parkitna JR and 8 others Neuron. 59(3):497-508. doi: 10.1016/j.neuron.2008.07.010. August 14, 2008. View on PubMed.
Ethanol sensitivity of GABAergic currents in cerebellar granule neurons is not increased by a single amino acid change (R100Q) in the alpha6 GABAA receptor subunit. Botta P, Mameli M, Floyd KL, Radcliffe RA, Valenzuela CF J Pharmacol Exp Ther. 323(2):684-91. doi: 10.1124/jpet.107.127894. August 17, 2007. View on PubMed.
Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Mameli M, Balland B, Luján R, Lüscher C Science. 317(5837):530-3. doi: 10.1126/science.1142365. July 27, 2007. View on PubMed.
Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder. Valenzuela CF, Partridge LD, Mameli M, Meyer DA Brain Res Rev. 57(2):506-19. doi: 10.1016/j.brainresrev.2007.04.009. May 3, 2007. View on PubMed.
Expression and function of SNAP-25 as a universal SNARE component in GABAergic neurons. Tafoya LC, Mameli M, Miyashita T, Guzowski JF, Valenzuela CF, Wilson MC J Neurosci. 26(30):7826-38. doi: 10.1523/JNEUROSCI.1866-06.2006. July 26, 2006. View on PubMed.
Connexin-36 gap junctions mediate electrical coupling between ventral tegmental area GABA neurons. Allison DW, Ohran AJ, Stobbs SH, Mameli M, Valenzuela CF, Sudweeks SN, Ray AP, Henriksen SJ, Steffensen SC Synapse. 60(1):20-31. doi: 10.1002/syn.20272. July 2006. View on PubMed.
Basis of the gabamimetic profile of ethanol. Breese GR, Criswell HE, Carta M, Dodson PD, Hanchar HJ, Khisti RT, Mameli M and 10 others Alcohol Clin Exp Res. 30(4):731-44. doi: 10.1111/j.0145-6008.2006.00086.x. April 2006. View on PubMed.
Alcohol potently modulates climbing fiber-->Purkinje neuron synapses: role of metabotropic glutamate receptors. Carta M, Mameli M, Valenzuela CF J Neurosci. 26(7):1906-12. doi: 10.1523/JNEUROSCI.4430-05.2006. February 15, 2006. View on PubMed.
Alcohol increases efficacy of immature synapses in a neurosteroid-dependent manner. Mameli M, Valenzuela CF Eur J Neurosci. 23(3):835-9. doi: 10.1111/j.1460-9568.2006.04597.x. February 2006. View on PubMed.
Actions of acute and chronic ethanol on presynaptic terminals. Roberto M, Treistman SN, Pietrzykowski AZ, Weiner J, Galindo R, Mameli M, Valenzuela F and 6 others Alcohol Clin Exp Res. 30(2):222-32. doi: 10.1111/j.1530-0277.2006.00030.x. February 2006. View on PubMed.
Developmentally regulated actions of alcohol on hippocampal glutamatergic transmission. Mameli M, Zamudio PA, Carta M, Valenzuela CF J Neurosci. 25(35):8027-36. doi: 10.1523/JNEUROSCI.2434-05.2005. August 31, 2005. View on PubMed.
Single-amino-acid difference in the sequence of alpha6 subunit dramatically increases the ethanol sensitivity of recombinant GABAA receptors. Valenzuela CF, Mameli M, Carta M Alcohol Clin Exp Res. 29(7):1356-7; author reply 1358. July 2005. View on PubMed.
Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors. Mameli M, Carta M, Partridge LD, Valenzuela CF J Neurosci. 25(9):2285-94. doi: 10.1523/JNEUROSCI.3877-04.2005. March 2, 2005. View on PubMed.
Neurosteroid paradoxical enhancement of paired-pulse inhibition through paired-pulse facilitation of inhibitory circuits in dentate granule cells. Thomas MJ, Mameli M, Carta M, Valenzuela CF, Li PK, Partridge LD Neuropharmacology. 48(4):584-96. doi: 10.1016/j.neuropharm.2004.11.014. March 2005. View on PubMed.
Fetal alcohol exposure alters neurosteroid levels in the developing rat brain. Caldeira JC, Wu Y, Mameli M, Purdy RH, Li PK, Akwa Y, Savage DD, Engen JR, Valenzuela CF J Neurochem. 90(6):1530-9. doi: 10.1111/j.1471-4159.2004.02686.x. September 2004. View on PubMed.
Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability. Carta M, Mameli M, Valenzuela CF J Neurosci. 24(15):3746-51. doi: 10.1523/JNEUROSCI.0067-04.2004. April 14, 2004. View on PubMed.
Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawal. Sanna E, Mostallino MC, Busonero F, Talani G, Tranquilli S, Mameli M, Spiga S, Follesa P, Biggio G J Neurosci. 23(37):11711-24. December 17, 2003. View on PubMed.
High affinity central benzodiazepine receptor ligands. Part 3: insights into the pharmacophore and pattern recognition study of intrinsic activities of pyrazolo[4,3-c]quinolin-3-ones. Carotti A, Altomare C, Savini L, Chiasserini L, Pellerano C, Mascia MP, Maciocco E and 4 others Bioorg Med Chem. 11(23):5259-72. November 17, 2003. View on PubMed.
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