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Luca Pellegrini

Associate Professor - Mitochondria Biology Laboratory

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Associate Professor - Mitochondria Biology Laboratory Aug 2000 - Present
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Publication Info
A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome. Kilkenny ML, Depiccoli G, Perera RL, Labib K, Pellegrini L J Biol Chem. :. doi: 10.1074/jbc.M112.368951. May 16, 2012. View on PubMed.
Incidence and predisposing factors of cold intolerance after arterial repair in upper extremity injuries. Klocker J, Peter T, Pellegrini L, Mattesich M, Loescher W, Sieb M, Klein-Weigel P, Fraedrich G J Vasc Surg. :. doi: 10.1016/j.jvs.2012.01.060. May 4, 2012. View on PubMed.
Structural and functional insights into DNA-end processing by the archaeal HerA helicase-NurA nuclease complex. Blackwood JK, Rzechorzek NJ, Abrams AS, Maman JD, Pellegrini L, Robinson NP Nucleic Acids Res. 40(7):3183-96. doi: 10.1093/nar/gkr1157. April 2012. View on PubMed.
[Interest of echocardiography in the diagnosis and monitoring of a pulmonary embolism complicating a free-floating thrombus in right heart cavities]. Pellegrini L, Le Dolley Y, Marot B, Riberi A, Bellezza M, Kerbaul F Ann Fr Anesth Reanim. 31(3):246-50. doi: 10.1016/j.annfar.2011.10.032. March 2012. View on PubMed.
[Rapid sequence induction in a patient with Steinert myotonic dystrophy: Interest of the association of high doses of rocuronium and sugammadex]. Pellegrini L, Mercier MF, Cornese A, Blasco V, Albanèse J Ann Fr Anesth Reanim. 31(2):155-7. doi: 10.1016/j.annfar.2011.10.031. February 2012. View on PubMed.
Vesicular zinc regulates the Ca2+ sensitivity of a subpopulation of presynaptic vesicles at hippocampal mossy fiber terminals. Lavoie N, Jeyaraju DV, Peralta MR 3rd, Seress L, Pellegrini L, Tóth K J Neurosci. 31(50):18251-65. doi: 10.1523/JNEUROSCI.4164-11.2011. December 14, 2011. View on PubMed.
Osteoporosis of the jaw. Product evaluation: mf Odontovis Calcium®. Luzzi R, Belcaro G, Cornelli U, Dugall M, Cesarone MR, Feragalli B, Ippolito E and 9 others Panminerva Med. 53(3 Suppl 1):83-7. September 2011. View on PubMed.
Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study. Appendino G, Belcaro G, Cornelli U, Luzzi R, Togni S, Dugall M, Cesarone MR and 12 others Panminerva Med. 53(3 Suppl 1):43-9. September 2011. View on PubMed.
Silver oxide ointment wound dressing in venous ulcerations: home, self-management. Belcaro G, Cesarone MR, Errichi BM, Ricci A, Antelman P, Dugall M, Pellegrini L, Ledda A, Viscardi G Panminerva Med. 53(3 Suppl 1):29-33. September 2011. View on PubMed.
Venoruton®: post thrombotic syndrome. Clinical improvement in venous insufficiency (signs and symptoms) with Venoruton®. A five-year, open-registry, efficacy study. Ippolito E, Belcaro G, Dugall M, Cesarone MR, Feragalli B, Errichi BM, Gizzi G and 8 others Panminerva Med. 53(3 Suppl 1):13-9. September 2011. View on PubMed.
Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site. Warr MR, Mills JR, Nguyen M, Lemaire-Ewing S, Baardsnes J, Sun KL, Malina A and 6 others J Biol Chem. 286(28):25098-107. doi: 10.1074/jbc.M111.218321. July 15, 2011. View on PubMed.
Structural and mechanistic basis of Parl activity and regulation. Jeyaraju DV, McBride HM, Hill RB, Pellegrini L Cell Death Differ. 18(9):1531-9. doi: 10.1038/cdd.2011.22. March 18, 2011. View on PubMed.
The PARL family of mitochondrial rhomboid proteases. Hill RB, Pellegrini L Semin Cell Dev Biol. 21(6):582-92. doi: 10.1016/j.semcdb.2009.12.011. January 4, 2010. View on PubMed.
Hax1 lacks BH modules and is peripherally associated to heavy membranes: implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis. Jeyaraju DV, Cisbani G, De Brito OM, Koonin EV, Pellegrini L Cell Death Differ. 16(12):1622-9. doi: 10.1038/cdd.2009.110. August 14, 2009. View on PubMed.
Calcium regulation of mitochondria motility and morphology. Jeyaraju DV, Cisbani G, Pellegrini L Biochim Biophys Acta. 1787(11):1363-73. doi: 10.1016/j.bbabio.2008.12.005. December 24, 2008. View on PubMed.
Extracellular chelation of zinc does not affect hippocampal excitability and seizure-induced cell death in rats. Lavoie N, Peralta MR 3rd, Chiasson M, Lafortune K, Pellegrini L, Seress L, Tóth K J Physiol. 578(Pt 1):275-89. doi: 10.1113/jphysiol.2006.121848. January 1, 2007. View on PubMed.
Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology. Jeyaraju DV, Xu L, Letellier MC, Bandaru S, Zunino R, Berg EA, McBride HM, Pellegrini L Proc Natl Acad Sci U S A. 103(49):18562-7. doi: 10.1073/pnas.0604983103. December 5, 2006. View on PubMed.
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K and 9 others Cell. 126(1):163-75. doi: 10.1016/j.cell.2006.06.021. July 14, 2006. View on PubMed.
Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields Pbeta, a nuclear-targeted peptide. Sík A, Passer BJ, Koonin EV, Pellegrini L J Biol Chem. 279(15):15323-9. doi: 10.1074/jbc.M313756200. April 9, 2004. View on PubMed.
The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers. Koonin EV, Makarova KS, Rogozin IB, Davidovic L, Letellier MC, Pellegrini L Genome Biol. 4(3):R19. February 28, 2003. View on PubMed.
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