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Alastair Stewart

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Degree - University  
BScHons PhD, respiratory/inflammation - The University of Melbourne 1980 - 1984
Publication Info
Long-term impact of radial artery harvest on forearm function and symptoms: A comparison with leg vein. Zhu YY, Hayward PA, Hadinata IE, Matalanis G, Buxton BF, Stewart AG, Hare DL J Thorac Cardiovasc Surg. :. doi: 10.1016/j.jtcvs.2012.01.052. February 22, 2012. View on PubMed.
The dynamic stator stalk of rotary ATPases. Stewart AG, Lee LK, Donohoe M, Chaston JJ, Stock D Nat Commun. 3:687. doi: 10.1038/ncomms1693. February 21, 2012. View on PubMed.
Transforming growth factor-β impairs glucocorticoid activity in the A549 lung adenocarcinoma cell line. Salem S, Harris T, Mok SL, Li MY, Keenan CR, Schuliga MJ, Stewart AG Br J Pharmacol. :. doi: 10.1111/j.1476-5381.2012.01885.x. February 2, 2012. View on PubMed.
Lipid management in high risk coronary patients: how effective are we at secondary intervention? Zhu YY, Hayward PA, Hare DL, Stewart AG, Buxton BF Heart Lung Circ. 21(2):82-7. doi: 10.1016/j.hlc.2011.10.013. February 2012. View on PubMed.
The influence of nitric oxide synthase 2 on cutaneous wound angiogenesis. Chin LC, Kumar P, Palmer JA, Rophael JA, Dolderer JH, Thomas GP, Morrison WA, Penington AJ, Stewart AG, Mitchell GM Br J Dermatol. 165(6):1223-35. doi: 10.1111/j.1365-2133.2011.10599.x. December 2011. View on PubMed.
Preface: selected papers from SEGH 2010 conference on environmental quality and human health. Zhang CS, Hursthouse AS, Stewart AG, Li XD, Thornton I Environ Geochem Health. 33(4):309-10. doi: 10.1007/s10653-011-9379-1. August 2011. View on PubMed.
Functional expression of IgG-Fc receptors in human airway smooth muscle cells. Xia YC, Schuliga M, Shepherd M, Powell M, Harris T, Langenbach SY, Tan PS and 4 others Am J Respir Cell Mol Biol. 44(5):665-72. doi: 10.1165/rcmb.2009-0371OC. May 2011. View on PubMed.
R2D(2) for C(4)Eo: an 'alliance' of PGD(2) receptors is required for LTC(4) production by human eosinophils. Mackay GA, Stewart AG Br J Pharmacol. 162(8):1671-3. doi: 10.1111/j.1476-5381.2011.01236.x. April 2011. View on PubMed.
Collagen remodelling by airway smooth muscle is resistant to steroids and β₂-agonists. Bourke JE, Li X, Foster SR, Wee E, Dagher H, Ziogas J, Harris T, Bonacci JV, Stewart AG Eur Respir J. 37(1):173-82. doi: 10.1183/09031936.00008109. January 2011. View on PubMed.
In vitro and in vivo evidence for anti-inflammatory properties of 2-methoxyestradiol. Shand FH, Langenbach SY, Keenan CR, Ma SP, Wheaton BJ, Schuliga MJ, Ziogas J, Stewart AG J Pharmacol Exp Ther. 336(3):962-72. doi: 10.1124/jpet.110.174854. December 21, 2010. View on PubMed.
Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. Khau T, Langenbach SY, Schuliga M, Harris T, Johnstone CN, Anderson RL, Stewart AG FASEB J. 25(2):483-96. doi: 10.1096/fj.09-154096. October 7, 2010. View on PubMed.
Major depression in cardiac patients is accurately assessed using the cardiac depression scale. Shi WY, Stewart AG, Hare DL Psychother Psychosom. 79(6):391-2. doi: 10.1159/000320897. September 9, 2010. View on PubMed.
Plasminogen activation by airway smooth muscle is regulated by type I collagen. Schuliga M, Harris T, Stewart AG Am J Respir Cell Mol Biol. 44(6):831-9. doi: 10.1165/rcmb.2009-0469OC. August 6, 2010. View on PubMed.
Airway smooth muscle remodels pericellular collagen fibrils: implications for proliferation. Schuliga M, Ong SC, Soon L, Zal F, Harris T, Stewart AG Am J Physiol Lung Cell Mol Physiol. 298(4):L584-92. doi: 10.1152/ajplung.00312.2009. January 15, 2010. View on PubMed.
Mediators and receptors in the resolution of inflammation: drug targeting opportunities. Stewart AG Br J Pharmacol. 158(4):933-5. doi: 10.1111/j.1476-5381.2009.00484.x. October 2009. View on PubMed.
Fibrillar collagen clamps lung mesenchymal cells in a nonproliferative and noncontractile phenotype. Schuliga MJ, See I, Ong SC, Soon L, Camoretti-Mercado B, Harris T, Stewart AG Am J Respir Cell Mol Biol. 41(6):731-41. doi: 10.1165/rcmb.2008-0361OC. March 27, 2009. View on PubMed.
Proliferation is not increased in airway myofibroblasts isolated from asthmatics. Ward JE, Harris T, Bamford T, Mast A, Pain MC, Robertson C, Smallwood D, Tran T, Wilson J, Stewart AG Eur Respir J. 32(2):362-71. doi: 10.1183/09031936.00119307. March 19, 2008. View on PubMed.
Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice. Langenbach SY, Wheaton BJ, Fernandes DJ, Jones C, Sutherland TE, Wraith BC, Harris T, Schuliga MJ, McLean C, Stewart AG Can J Physiol Pharmacol. 85(7):727-38. doi: 10.1139/Y07-065. July 2007. View on PubMed.
2-Methoxyestradiol--a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents. Sutherland TE, Anderson RL, Hughes RA, Altmann E, Schuliga M, Ziogas J, Stewart AG Drug Discov Today. 12(13-14):577-84. doi: 10.1016/j.drudis.2007.05.005. June 26, 2007. View on PubMed.
KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation. Shepherd MC, Duffy SM, Harris T, Cruse G, Schuliga M, Brightling CE, Neylon CB, Bradding P, Stewart AG Am J Respir Cell Mol Biol. 37(5):525-31. doi: 10.1165/rcmb.2006-0358OC. June 21, 2007. View on PubMed.
Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. An SS, Bai TR, Bates JH, Black JL, Brown RH, Brusasco V, Chitano P and 46 others Eur Respir J. 29(5):834-60. doi: 10.1183/09031936.00112606. May 2007. View on PubMed.
Collagen impairs glucocorticoid actions in airway smooth muscle through integrin signalling. Bonacci JV, Schuliga M, Harris T, Stewart AG Br J Pharmacol. 149(4):365-73. doi: 10.1038/sj.bjp.0706881. September 11, 2006. View on PubMed.
Airway remodelling in asthma: current understanding and implications for future therapies. Tang ML, Wilson JW, Stewart AG, Royce SG Pharmacol Ther. 112(2):474-88. doi: 10.1016/j.pharmthera.2006.05.001. June 8, 2006. View on PubMed.
Extracellular matrix, integrins, and mesenchymal cell function in the airways. Fernandes DJ, Bonacci JV, Stewart AG Curr Drug Targets. 7(5):567-77. May 2006. View on PubMed.
Molecular and cellular targets in tissue remodelling. Stewart AG, Ziogas J Pulm Pharmacol Ther. 19(1):1-2. 2006. View on PubMed.
The PPARgamma ligand, rosiglitazone, reduces airways hyperresponsiveness in a murine model of allergen-induced inflammation. Ward JE, Fernandes DJ, Taylor CC, Bonacci JV, Quan L, Stewart AG Pulm Pharmacol Ther. 19(1):39-46. doi: 10.1016/j.pupt.2005.02.005. April 25, 2005. View on PubMed.
Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen-specific. Fernandes DJ, Ravenhall CE, Harris T, Tran T, Vlahos R, Stewart AG Br J Pharmacol. 142(7):1182-90. doi: 10.1038/sj.bjp.0705809. July 12, 2004. View on PubMed.
Factors controlling airway smooth muscle proliferation in asthma. Stewart AG, Bonacci JV, Quan L Curr Allergy Asthma Rep. 4(2):109-15. March 2004. View on PubMed.
Quantitative phase microscopy: a new tool for measurement of cell culture growth and confluency in situ. Curl CL, Harris T, Harris PJ, Allman BE, Bellair CJ, Stewart AG, Delbridge LM Pflugers Arch. 448(4):462-8. doi: 10.1007/s00424-004-1248-7. February 17, 2004. View on PubMed.
PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms. Ward JE, Gould H, Harris T, Bonacci JV, Stewart AG Br J Pharmacol. 141(3):517-25. doi: 10.1038/sj.bjp.0705630. January 12, 2004. View on PubMed.
Do inflammatory mediators influence the contribution of airway smooth muscle contraction to airway hyperresponsiveness in asthma? Fernandes DJ, Mitchell RW, Lakser O, Dowell M, Stewart AG, Solway J J Appl Physiol. 95(2):844-53. doi: 10.1152/japplphysiol.00192.2003. August 2003. View on PubMed.
Impact of extracellular matrix and strain on proliferation of bovine airway smooth muscle. Bonacci JV, Harris T, Stewart AG Clin Exp Pharmacol Physiol. 30(5-6):324-8. June 2003. View on PubMed.
Collagen-induced resistance to glucocorticoid anti-mitogenic actions: a potential explanation of smooth muscle hyperplasia in the asthmatic remodelled airway. Bonacci JV, Harris T, Wilson JW, Stewart AG Br J Pharmacol. 138(7):1203-6. doi: 10.1038/sj.bjp.0705135. April 2003. View on PubMed.
Protease-activated receptor (PAR)-independent growth and pro-inflammatory actions of thrombin on human cultured airway smooth muscle. Tran T, Stewart AG Br J Pharmacol. 138(5):865-75. doi: 10.1038/sj.bjp.0705106. March 2003. View on PubMed.
Differential inhibition of thrombin- and EGF-stimulated human cultured airway smooth muscle proliferation by glucocorticoids. Vlahos R, Lee KS, Guida E, Fernandes DJ, Wilson JW, Stewart AG Pulm Pharmacol Ther. 16(3):171-80. doi: 10.1016/S1094-5539(02)00183-9. 2003. View on PubMed.
Antigen-induced airway inflammation in the Brown Norway rat results in airway smooth muscle hyperplasia. Xu KF, Vlahos R, Messina A, Bamford TL, Bertram JF, Stewart AG J Appl Physiol. 93(5):1833-40. doi: 10.1152/japplphysiol.00738.2001. November 2002. View on PubMed.
Growing up and advancing in airway smooth muscle research. Chitano P, Halayko AJ, Murphy TM, Stewart AG Trends Pharmacol Sci. 23(10):450-1. October 2002. View on PubMed.
A randomized phase II trial of granulocyte-macrophage colony-stimulating factor therapy in severe sepsis with respiratory dysfunction. Presneill JJ, Harris T, Stewart AG, Cade JF, Wilson JW Am J Respir Crit Care Med. 166(2):138-43. doi: 10.1164/rccm.2009005. July 15, 2002. View on PubMed.
2-Methoxyestradiol and analogs as novel antiproliferative agents: analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding. Hughes RA, Harris T, Altmann E, McAllister D, Vlahos R, Robertson A, Cushman M, Wang Z, Stewart AG Mol Pharmacol. 61(5):1053-69. May 2002. View on PubMed.
Anti-remodelling drugs for the treatment of asthma: requirement for animal models of airway wall remodelling. Fernandes DJ, Xu KF, Stewart AG Clin Exp Pharmacol Physiol. 28(8):619-29. August 2001. View on PubMed.
Effects of the endothelin receptor antagonist Bosentan on ischaemia/reperfusion injury in rat skeletal muscle. Herbert KJ, Hickey MJ, Lepore DA, Knight KR, Morrison WA, Stewart AG Eur J Pharmacol. 424(1):59-67. July 13, 2001. View on PubMed.
Lipopolysaccharide-induced cell cycle arrest in macrophages occurs independently of nitric oxide synthase II induction. Vadiveloo PK, Keramidaris E, Morrison WA, Stewart AG Biochim Biophys Acta. 1539(1-2):140-6. May 28, 2001. View on PubMed.
Targeted disruption of the nitric oxide synthase 2 gene protects against ischaemia/reperfusion injury to skeletal muscle. Barker JE, Knight KR, Romeo R, Hurley JV, Morrison WA, Stewart AG J Pathol. 194(1):109-15. doi: 10.1002/path.845. May 2001. View on PubMed.
Inducible nitric oxide synthase (iNOS) activity promotes ischaemic skin flap survival. Kane AJ, Barker JE, Mitchell GM, Theile DR, Romero R, Messina A, Wagh M, Fraulin FO, Morrison WA, Stewart AG Br J Pharmacol. 132(8):1631-8. doi: 10.1038/sj.bjp.0703944. April 2001. View on PubMed.
Nitric oxide synthase II gene disruption: implications for tumor growth and vascular endothelial growth factor production. Konopka TE, Barker JE, Bamford TL, Guida E, Anderson RL, Stewart AG Cancer Res. 61(7):3182-7. April 1, 2001. View on PubMed.
Airway wall remodelling and hyperresponsiveness: modelling remodelling in vitro and in vivo. Stewart AG Pulm Pharmacol Ther. 14(3):255-65. doi: 10.1006/pupt.2001.0290. 2001. View on PubMed.
Prior heat stress improves survival of ischemic-reperfused skeletal muscle in vivo. Lepore DA, Hurley JV, Stewart AG, Morrison WA, Anderson RL Muscle Nerve. 23(12):1847-55. December 2000. View on PubMed.
Localization of inducible nitric oxide synthase to mast cells during ischemia/reperfusion injury of skeletal muscle. Messina A, Knight KR, Dowsing BJ, Zhang B, Phan LH, Hurley JV, Morrison WA, Stewart AG Lab Invest. 80(3):423-31. March 2000. View on PubMed.
Neutrophil-independent protective effect of r-metHuG-CSF in ischaemia-reperfusion injury in rat skeletal muscle. Leong JC, Knight KR, Hickey MJ, Morrison WA, Stewart AG Int J Exp Pathol. 81(1):41-9. February 2000. View on PubMed.
Thrombin-stimulated DNA synthesis in human cultured airway smooth muscle occurs independently of products of cyclo-oxygenase or 5-lipoxygenase. Fernandes D, Vlahos R, Stewart AG Pulm Pharmacol Ther. 13(5):241-8. doi: 10.1006/pupt.2000.0251. 2000. View on PubMed.
Beta2-adrenergic receptor agonists and cAMP arrest human cultured airway smooth muscle cells in the G(1) phase of the cell cycle: role of proteasome degradation of cyclin D1. Stewart AG, Harris T, Fernandes DJ, Schachte LC, Koutsoubos V, Guida E, Ravenhall CE, Vadiveloo P, Wilson JW Mol Pharmacol. 56(5):1079-86. November 1999. View on PubMed.
Airway vascularity in asthma. Wilson JW, Stewart AG Clin Exp Allergy. 29(10):1295-7. October 1999. View on PubMed.
The survival of skeletal muscle myoblasts in vitro is sensitive to a donor of nitric oxide and superoxide, SIN-1, but not to nitric oxide or peroxynitrite alone. Lepore DA, Stewart AG, Tomasi A, Anderson RL, Hurley JV, Morrison WA Nitric Oxide. 3(4):273-80. doi: 10.1006/niox.1999.0239. August 1999. View on PubMed.
Glucocorticoids inhibit proliferation, cyclin D1 expression, and retinoblastoma protein phosphorylation, but not activity of the extracellular-regulated kinases in human cultured airway smooth muscle. Fernandes D, Guida E, Koutsoubos V, Harris T, Vadiveloo P, Wilson JW, Stewart AG Am J Respir Cell Mol Biol. 21(1):77-88. doi: 10.1165/ajrcmb.21.1.3396. July 1999. View on PubMed.
Muscle cells become necrotic rather than apoptotic during reperfusion of ischaemic skeletal muscle. Knight KR, Messina A, Hurley JV, Zhang B, Morrison WA, Stewart AG Int J Exp Pathol. 80(3):169-75. June 1999. View on PubMed.
Interleukin-1alpha and tumour necrosis factor-alpha modulate airway smooth muscle DNA synthesis by induction of cyclo-oxygenase-2: inhibition by dexamethasone and fluticasone propionate. Vlahos R, Stewart AG Br J Pharmacol. 126(6):1315-24. doi: 10.1038/sj.bjp.0702424. March 1999. View on PubMed.
Nitric oxide synthase-independent generation of nitric oxide in rat skeletal muscle ischemia-reperfusion injury. Lepore DA, Kozlov AV, Stewart AG, Hurley JV, Morrison WA, Tomasi A Nitric Oxide. 3(1):75-84. doi: 10.1006/niox.1999.0211. 1999. View on PubMed.
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