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Ferdinando Chiaradonna

Assistant Professor - University of Milano Bicocca

Position - Company  
Research fellow - European Institute of Oncology


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1997 - 2003
Research fellow - Istituto Internazionale di Genetica e Biofisica


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Mar 1993 - Aug 1997
Assistant Professor - University of Milano Bicocca Oct 2002 - Present
Degree - University  
PhD in cell biology, Biology - Open University of London 1999 - 2005
Master in Biological Sciences - Università degli Studi di Napoli 'Federico II' 1985 - 1993
Publication Info
Oncogenic K-ras expression is associated with derangement of the cAMP/PKA pathway and forskolin-reversible alterations of mitochondrial dynamics and respiration. Palorini R, De Rasmo D, Gaviraghi M, Danna LS, Signorile A, Cirulli C, Chiaradonna F, Alberghina L, Papa S Oncogene. :. doi: 10.1038/onc.2012.50. March 12, 2012. View on PubMed.
Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Gaglio D, Metallo CM, Gameiro PA, Hiller K, Danna LS, Balestrieri C, Alberghina L, Stephanopoulos G, Chiaradonna F Mol Syst Biol. 7:523. doi: 10.1038/msb.2011.56. August 16, 2011. View on PubMed.
From cancer metabolism to new biomarkers and drug targets. Chiaradonna F, Moresco RM, Airoldi C, Gaglio D, Palorini R, Nicotra F, Messa C, Alberghina L Biotechnol Adv. 30(1):30-51. doi: 10.1016/j.biotechadv.2011.07.006. July 23, 2011. View on PubMed.
Integrative transcriptional analysis between human and mouse cancer cells provides a common set of transformation associated genes. Balestrieri C, Vanoni M, Hautaniemi S, Alberghina L, Chiaradonna F Biotechnol Adv. 30(1):16-29. doi: 10.1016/j.biotechadv.2011.06.013. June 29, 2011. View on PubMed.
Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells. Baracca A, Chiaradonna F, Sgarbi G, Solaini G, Alberghina L, Lenaz G Biochim Biophys Acta. 1797(2):314-23. doi: 10.1016/j.bbabio.2009.11.006. November 18, 2009. View on PubMed.
Towards a systems biology approach to mammalian cell cycle: modeling the entrance into S phase of quiescent fibroblasts after serum stimulation. Alfieri R, Barberis M, Chiaradonna F, Gaglio D, Milanesi L, Vanoni M, Klipp E, Alberghina L BMC Bioinformatics. 10 Suppl 12:S16. doi: 10.1186/1471-2105-10-S12-S16. October 15, 2009. View on PubMed.
Data recovery and integration from public databases uncovers transformation-specific transcriptional downregulation of cAMP-PKA pathway-encoding genes. Balestrieri C, Alberghina L, Vanoni M, Chiaradonna F BMC Bioinformatics. 10 Suppl 12:S1. doi: 10.1186/1471-2105-10-S12-S1. October 15, 2009. View on PubMed.
Glutamine deprivation induces abortive s-phase rescued by deoxyribonucleotides in k-ras transformed fibroblasts. Gaglio D, Soldati C, Vanoni M, Alberghina L, Chiaradonna F PLoS One. 4(3):e4715. doi: 10.1371/journal.pone.0004715. March 5, 2009. View on PubMed.
RAS and PKA pathways in cancer: new insight from transcriptional analysis. Chiaradonna F, Balestrieri C, Gaglio D, Vanoni M Front Biosci. 13:5257-78. May 1, 2008. View on PubMed.
Ras-dependent carbon metabolism and transformation in mouse fibroblasts. Chiaradonna F, Sacco E, Manzoni R, Giorgio M, Vanoni M, Alberghina L Oncogene. 25(39):5391-404. doi: 10.1038/sj.onc.1209528. August 31, 2006. View on PubMed.
Expression of transforming K-Ras oncogene affects mitochondrial function and morphology in mouse fibroblasts. Chiaradonna F, Gaglio D, Vanoni M, Alberghina L Biochim Biophys Acta. 1757(9-10):1338-56. doi: 10.1016/j.bbabio.2006.08.001. August 3, 2006. View on PubMed.
Acquired glucose sensitivity of k-ras transformed fibroblasts. Chiaradonna F, Magnani C, Sacco E, Manzoni R, Alberghina L, Vanoni M Biochem Soc Trans. 33(Pt 1):297-9. doi: 10.1042/BST0330297. February 2005. View on PubMed.
Systems biology and the molecular circuits of cancer. Alberghina L, Chiaradonna F, Vanoni M Chembiochem. 5(10):1322-33. doi: 10.1002/cbic.200400170. October 4, 2004. View on PubMed.
AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor. Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S and 5 others Cancer Res. 62(23):7050-8. December 1, 2002. View on PubMed.
Common themes in the pathogenesis of acute myeloid leukemia. Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT and 5 others Oncogene. 20(40):5680-94. doi: 10.1038/sj.onc.1204642. September 10, 2001. View on PubMed.
Urokinase receptor-dependent and -independent p56/59(hck) activation state is a molecular switch between myelomonocytic cell motility and adherence. Chiaradonna F, Fontana L, Iavarone C, Carriero MV, Scholz G, Barone MV, Stoppelli MP EMBO J. 18(11):3013-23. doi: 10.1093/emboj/18.11.3013. June 1, 1999. View on PubMed.
Protein kinase C-dependent in vivo phosphorylation of prourokinase leads to the formation of a receptor competitive antagonist. Franco P, Massa O, Garcia-Rocha M, Chiaradonna F, Iaccarino C, Correas I, Mendez E, Avila J, Blasi F, Stoppelli MP J Biol Chem. 273(42):27734-40. October 16, 1998. View on PubMed.
Vitronectin binding to urokinase receptor in human breast cancer. Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M Clin Cancer Res. 3(8):1299-308. August 1997. View on PubMed.
Phosphorylation of human pro-urokinase on Ser138/303 impairs its receptor-dependent ability to promote myelomonocytic adherence and motility. Franco P, Iaccarino C, Chiaradonna F, Brandazza A, Iavarone C, Mastronicola MR, Nolli ML, Stoppelli MP J Cell Biol. 137(3):779-91. May 5, 1997. View on PubMed.
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