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Maksym Kopanitsa

Chief Operating Officer - Synome Ltd.

Position - Company  
Research Associate/Senior Staff Scientist - Wellcome Trust Sanger Institute

-Developed a multi-electrode array-based assay of synaptic transmission in hippocampal slices and applied it to a large cohort (>50) of genetically altered mouse lines;
-Worked out protocols for pharmacological stimulation of brain slices for subsequent biochemical analyses (protein phosphorylation, mRNA concentration, etc);
-Substantially expanded and curated in-house literature database on synaptic phenotypes in mutant mice;
-Performed bioinformatic data search and analysis using Ensembl, MGI, PantherDB, Homologene, BioGPS, String databases;
-Managed a Research Assistant and taught two post-graduate students fundamentals of brain dissection

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Sep 2004 - Aug 2010
Postdoctoral Researcher - University of Dundee

-Investigated pharmacological sensitivity of Purkinje cell firing in cerebellar slices from mutant mice using cell-attached recordings;
-Performed whole-cell patch clamp recordings of miniature synaptic currents in slices of various brain regions (neocortex, hippocampus, cerebellum, dorsal raphe, suprachiasmatic nucleus);
-Transfected Xenopus oocytes with mRNA coding for subunits of GABAA receptors and analysed modulation of GABA-induced currents by benzodiazepines and derivatives of aminobenzophenones

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Apr 2003 - Aug 2004
Junior/Staff Researcher - Bogomoletz Institute of Physiology

-Studied voltage-activated and ligand-gated ion currents in enzymatically dissociated neurones from various brain areas (hippocampus, cerebellum) and sensory ganglia (dorsal root, trigeminal);
-Performed analysis of pharmacological sensitivity of excitatory synaptic transmission in hippocampal slices using whole-cell patch clamp recordings and measurements of extracellular field potentials;
-Carried out electrophysiological studies of various natural and synthetic compounds within commercial collaborations with pharmaceutical companies;
-Assisted in supervising research projects of two undergraduate students

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Sep 1997 - Apr 2003
Laboratory Assistant - A.V. Bogatsky Physico-Chemical Institute

Evaluated an acoustic startle response assay for pharmacodynamic assessment of ethanol and 1,4-benzodiazepines

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Jan 1993 - Aug 1994
Summer Intern - Syntex Discovery Research

-Investigated pharmacological properties of a novel Ca2+ influx pathway in HL-60 cells by Fura-2AM based imaging

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Apr 1992 - Jul 1992
Chief Operating Officer - Synome Ltd. Babraham Research Campus

Current duties include:
-Management and implementation of contract research activities in electrophysiology, biochemistry and rodent behaviour for pharmaceutical companies;
-Supervision, execution, scientific reporting and financial planning of research activities in electrophysiology, rodent behaviour and molecular biology within four EU 7th Framework Programme projects “PharMEA”, “Eurospin”, “Gencodys” and “Synsys”;);
-Line management of a Research Manager and 3 Research Associates

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Sep 2010 - Present
Degree - University  
Cand. Biol. Sci. (Ph.D.), Neuroscience - Bogomoletz Institute of Physiology, National Academy of Science of Ukraine 2011 - 2011
Diploma of Higher Education, Biology - Odessa Mechnikov State University, Ukraine

specialisation in Animal and Human Physiology; qualified teacher of Biology and Chemistry

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1989 - 1994
American Collegiate Consortium Exchange Program, Biology - Bates College

GPA 3.41/4.00

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1991 - 1992
Publication Info
Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome. Balemans MC, Kasri NN, Kopanitsa MV, Afinowi NO, Ramakers G, Peters TA, Beynon AJ and 10 others Hum Mol Genet. 22(5):852-66. doi: 10.1093/hmg/dds490. March 1, 2013. View on PubMed.
Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior. Ryan TJ, Kopanitsa MV, Indersmitten T, Nithianantharajah J, Afinowi NO, Pettit C, Stanford LE and 6 others Nat Neurosci. 16(1):25-32. doi: 10.1038/nn.3277. January 2013. View on PubMed.
TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function. Coba MP, Komiyama NH, Nithianantharajah J, Kopanitsa MV, Indersmitten T, Skene NG, Tuck EJ and 8 others J Neurosci. 32(40):13987-99. doi: 10.1523/JNEUROSCI.2433-12.2012. October 3, 2012. View on PubMed.
Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins. Fernández E, Collins MO, Uren RT, Kopanitsa MV, Komiyama NH, Croning MD, Zografos L, Armstrong JD, Choudhary JS, Grant SG Mol Syst Biol. 5:269. doi: 10.1038/msb.2009.27. May 19, 2009. View on PubMed.
Neurotransmitters drive combinatorial multistate postsynaptic density networks. Coba MP, Pocklington AJ, Collins MO, Kopanitsa MV, Uren RT, Swamy S, Croning MD, Choudhary JS, Grant SG Sci Signal. 2(68):ra19. doi: 10.1126/scisignal.2000102. April 28, 2009. View on PubMed.
Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus. Coba MP, Valor LM, Kopanitsa MV, Afinowi NO, Grant SG J Biol Chem. 283(49):34101-7. doi: 10.1074/jbc.M804951200. December 5, 2008. View on PubMed.
Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays. Kopanitsa MV, Afinowi NO, Grant SG BMC Neurosci. 7:61. doi: 10.1186/1471-2202-7-61. August 30, 2006. View on PubMed.
[Effect of phenazepam metabolite, 2-amino-5-bromo-2'-chlorobenzophenone, on glycine and glutamate NMDA receptors of rat hippocampal pyramidal neurones]. Kopanytsia MV Fiziol Zh. 49(1):23-7. 2003. View on PubMed.
Modulation of GABA(A) receptor-mediated currents by benzophenone derivatives in isolated rat Purkinje neurones. Kopanitsa MV, Yakubovska LM, Rudenko OP, Krishtal OA Neuropharmacology. 43(4):764-77. September 2002. View on PubMed.
[Adaptation of synaptic transmission to high concentrations of homocysteinic acid]. Boĭchuk IaA, Kopanytsia MV, Lozova NO Ukr Biokhim Zh. 73(5):114-8. October 2001. View on PubMed.
Pharmacokinetics of ethanol in mice with different alcohol motivation. Golovenko NY, Zhuk MS, Zin'kovskii VG, Zhuk OV, Kopanitsa MV Bull Exp Biol Med. 132(3):852-5. September 2001. View on PubMed.
Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum. Krishtal O, Lozovaya N, Fisunov A, Tsintsadze T, Pankratov Y, Kopanitsa M, Chatterjee SS Pharmacopsychiatry. 34 Suppl 1:S74-82. July 2001. View on PubMed.
Modulation of GABAA receptor-mediated currents by phenazepam and its metabolites. Kopanitsa MV, Zhuk OV, Zinkovsky VG, Krishtal OA Naunyn Schmiedebergs Arch Pharmacol. 364(1):1-8. July 2001. View on PubMed.
[Use of the acoustic startle response in the mouse to evaluate the pharmacodynamic action of ethanol]. Kopanytsia MV, Vasylinin HB, Fedorova OA, Chekhovs'kyĭ VP, Zhuk OV, Zin'kovs'kyĭ VH Fiziol Zh. 47(2):106-14. 2001. View on PubMed.
Inhibitory action of ambocarb on voltage-operated sodium channels in rat isolated hippocampal pyramidal neurons. Kopanitsa MV, Krishtal OA, Komissarov IV Clin Exp Pharmacol Physiol. 27(1-2):46-54. February 2000. View on PubMed.
Enhancement of glutamate release uncovers spillover-mediated transmission by N-methyl-D-aspartate receptors in the rat hippocampus. Lozovaya NA, Kopanitsa MV, Boychuk YA, Krishtal OA Neuroscience. 91(4):1321-30. 1999. View on PubMed.
Kava extract ingredients, (+)-methysticin and (+/-)-kavain inhibit voltage-operated Na(+)-channels in rat CA1 hippocampal neurons. Magura EI, Kopanitsa MV, Gleitz J, Peters T, Krishtal OA Neuroscience. 81(2):345-51. November 1997. View on PubMed.
Capsaicin blocks Ca2+ channels in isolated rat trigeminal and hippocampal neurones. Kopanitsa MV, Panchenko VA, Magura EI, Lishko PV, Krishtal OA Neuroreport. 6(17):2338-40. November 27, 1995. View on PubMed.
Pharmacology of a Ca(2+)-influx pathway activated by emptying the intracellular Ca2+ stores in HL-60 cells: evidence that a cytochrome P-450 is not involved. Koch BD, Faurot GF, Kopanitsa MV, Swinney DC Biochem J. 302 ( Pt 1):187-90. August 15, 1994. View on PubMed.
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