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Gavin Mc Stay

Associate Research Scientist - Columbia University

Position - Company  
Post-doctoral scientist - Columbia University Apr 2010 - Aug 2011
Post-doctoral research associate - St Jude Children's Research Hospital

Characterization of caspases and BCL-2 family proteins in models of cell death

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Aug 2005 - Apr 2010
Post-doctoral research fellow - La Jolla Institute for Allergy and Immunology

Characterization of caspases and BCL-2 family proteins in models of cell death

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2003 - 2005
PhD student - University of Bristol

Investigation of the interaction of the adenine nucleotide translocase and cyclophilin-D in the formation of the mitochondrial permeability transition pore

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1999 - 2003
Industrial trainee - MitoKor

Investigation of the interaction of the adenine nucleotide translocase and cyclophilin-D in the formation of the mitochondrial permeability transition pore

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2002 - 2002
Industrial trainee - Astra Charnwood

Characterization of novel immunomodulatory molecules

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1997 - 1998
Associate Research Scientist - Columbia University Aug 2011 - Present
Degree - University  
PhD, Biochemistry - University of Bristol 1999 - 2003
BSc, Biochemistry - University of Leeds 1995 - 1999
Publication Info
Mitochondrial pathway of apoptosis is ancestral in metazoans. Bender CE, Fitzgerald P, Tait SW, Llambi F, McStay GP, Tupper DO, Pellettieri J, Sánchez Alvarado A, Salvesen GS, Green DR Proc Natl Acad Sci U S A. 109(13):4904-9. doi: 10.1073/pnas.1120680109. March 27, 2012. View on PubMed.
Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Chipuk JE, McStay GP, Bharti A, Kuwana T, Clarke CJ, Siskind LJ, Obeid LM, Green DR Cell. 148(5):988-1000. doi: 10.1016/j.cell.2012.01.038. March 2, 2012. View on PubMed.
Turnover of ATP synthase subunits in F1-depleted HeLa and yeast cells. Rak M, McStay GP, Fujikawa M, Yoshida M, Manfredi G, Tzagoloff A FEBS Lett. 585(16):2582-6. doi: 10.1016/j.febslet.2011.07.011. August 19, 2011. View on PubMed.
Characterization of cytoplasmic caspase-2 activation by induced proximity. Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SW, Dillon CP, Flanagan JM, Beere HM, Green DR Mol Cell. 35(6):830-40. doi: 10.1016/j.molcel.2009.07.023. September 24, 2009. View on PubMed.
Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. McStay GP, Salvesen GS, Green DR Cell Death Differ. 15(2):322-31. doi: 10.1038/sj.cdd.4402260. November 2, 2007. View on PubMed.
In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Tu S, McStay GP, Boucher LM, Mak T, Beere HM, Green DR Nat Cell Biol. 8(1):72-7. doi: 10.1038/ncb1340. December 18, 2005. View on PubMed.
Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Spierings D, McStay G, Saleh M, Bender C, Chipuk J, Maurer U, Green DR Science. 310(5745):66-7. doi: 10.1126/science.1117105. October 7, 2005. View on PubMed.
Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore. McStay GP, Clarke SJ, Halestrap AP Biochem J. 367(Pt 2):541-8. doi: 10.1042/BJ20011672. October 15, 2002. View on PubMed.
Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A. Clarke SJ, McStay GP, Halestrap AP J Biol Chem. 277(38):34793-9. doi: 10.1074/jbc.M202191200. September 20, 2002. View on PubMed.
The permeability transition pore complex: another view. Halestrap AP, McStay GP, Clarke SJ Biochimie. 84(2-3):153-66. March 2002. View on PubMed.
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