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Michael Markey

Director, Center for Genomics Research - Wright State University

The Center for Genomics Research (CGR) is a joint core facility of Boonshoft School of Medicine and the College of Science and Mathematics at Wright State University. CGR's primary mission is to provide research support and core facilities for researchers engaged in basic and clinical research in the areas of gene expression, flow cytometry and genotyping. The center strives to cultivate collaborations between basic and clinical researchers through training of personnel, collaborative projects undertaken at CGR and joint grant submissions.

For more information about CGR, contact Dr. Michael Markey (phone: 937-775-4536; email: michael.markey@wright.edu.)

Position - Company  
Director, Center for Genomics Research - Wright State University Jan 2008 - Present
Degree - University  
Ph.D., Cell Biology - University of Cincinnati 2000 - 2004
BS, Molecular Biology - Murray State University 1996 - 2000
Publication Info
Sarcoptes scabiei Mites Modulate Gene Expression in Human Skin Equivalents. Morgan MS, Arlian LG, Markey MP PLoS One. 8(8):e71143. doi: 10.1371/journal.pone.0071143. August 5, 2013. View on PubMed.
MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame. Mandke P, Wyatt N, Fraser J, Bates B, Berberich SJ, Markey MP PLoS One. 7(8):e42034. doi: 10.1371/journal.pone.0042034. 2012. View on PubMed.
Son maintains accurate splicing for a subset of human pre-mRNAs. Sharma A, Markey M, Torres-Muñoz K, Varia S, Kadakia M, Bubulya A, Bubulya PA J Cell Sci. 124(Pt 24):4286-98. doi: 10.1242/jcs.092239. December 15, 2011. View on PubMed.
Regulation of MDM4. Markey MP Front Biosci (Landmark Ed). 16:1144-56. January 1, 2011. View on PubMed.
Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53. Heminger K, Markey M, Mpagi M, Berberich SJ Aging (Albany NY). 1(1):89-108. doi: 10.18632/aging.100008. January 2009. View on PubMed.
Full-length hdmX transcripts decrease following genotoxic stress. Markey M, Berberich SJ Oncogene. 27(52):6657-66. doi: 10.1038/onc.2008.266. November 6, 2008. View on PubMed.
Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function. Markey MP, Bergseid J, Bosco EE, Stengel K, Xu H, Mayhew CN, Schwemberger SJ and 8 others Oncogene. 26(43):6307-18. doi: 10.1038/sj.onc.1210450. September 20, 2007. View on PubMed.
Geminin is targeted for repression by the retinoblastoma tumor suppressor pathway through intragenic E2F sites. Markey M, Siddiqui H, Knudsen ES J Biol Chem. 279(28):29255-62. doi: 10.1074/jbc.M313482200. July 9, 2004. View on PubMed.
RB reversibly inhibits DNA replication via two temporally distinct mechanisms. Angus SP, Mayhew CN, Solomon DA, Braden WA, Markey MP, Okuno Y, Cardoso MC, Gilbert DM, Knudsen ES Mol Cell Biol. 24(12):5404-20. doi: 10.1128/MCB.24.12.5404-5420.2004. June 2004. View on PubMed.
Unbiased analysis of RB-mediated transcriptional repression identifies novel targets and distinctions from E2F action. Markey MP, Angus SP, Strobeck MW, Williams SL, Gunawardena RW, Aronow BJ, Knudsen ES Cancer Res. 62(22):6587-97. November 15, 2002. View on PubMed.
Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication. Angus SP, Wheeler LJ, Ranmal SA, Zhang X, Markey MP, Mathews CK, Knudsen ES J Biol Chem. 277(46):44376-84. doi: 10.1074/jbc.M205911200. November 15, 2002. View on PubMed.
Active RB elicits late G1/S inhibition. Angus SP, Fribourg AF, Markey MP, Williams SL, Horn HF, DeGregori J, Kowalik TF, Fukasawa K, Knudsen ES Exp Cell Res. 276(2):201-13. doi: 10.1006/excr.2002.5510. June 10, 2002. View on PubMed.
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