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Graham Pawelec

Professor - University of Tübingen Clinical School View Biosketch →

http://www.tati-group.de/

Position - Company  
Director - Tübingen Ageing and Tumour Immunology Group (TATI) 2012 - 2012
Honorary Professor - The University of Manchester Sep 2010 - Present
Visiting Professor - Nottingham Trent University Jun 2005 - Present
Professor - University of Tübingen Clinical School

Graham Pawelec heads the Tübingen Ageing and Tumour Immunology Group (TATI) at the Center for Medical Research (ZMF) of Tübingen University Medical School.

Research and teaching interests of the group are encompassed by the keywords immunosenescence, vaccination, T cell subsets, tumor immunity, immunotherapy, cytokines, longitudinal studies, human longevity, immunity and aging. Our expertise (human immunology) is in polychromatic flow cytometry, T cell cloning, confocal microscopy, proteomics, signal transduction, hypoxia, antigen identification, immune monitoring, cancer vaccination, influenza vaccination. The TATI working hypothesis is that chronic antigenic stress contributes to the observed T cell immune dysregulation in both ageing and cancer, and possibly other pathologies. In ageing, important chronic stressors include persistent viruses; Cytomegalovirus is especially relevant in this regard. At least initially, all cancers are immunogenic; hence the chronic stressors in this situation are tumour antigens.

The behaviour of T cells ex vivo (isolated from cancer patients, healthy elderly and Alzheimer patients) is being investigated 1) in a search for biomarkers of ageing identified in the TCC culture model above; 2) to monitor disease progression and provide a basis for rational inervention. To this end, TATI infrastructure previously incorporated programs to discover new tumour antigens in melanoma and leukaemia (now in the hands of companies like Immatics), tumour cell and patient lymphocyte characterisation and banking, monitoring of cancer patients undergoing immunotherapy, monitoring of the elderly in longitudinal ageing studies and characterisation and banking of cells from the elderly, from centenarians and others.

Show details
Nov 1987 - Present
Professor - University of Tübingen 2012 - Present
Degree - University  
PhD, Transplantation immunology - University of Cambridge 1974 - 1982
PhD, Transplantation Immunology - University of Cambridge 1970 - 1978
Publication Info
Evaluating the physiological reserves of older patients with cancer: The value of potential biomarkers of aging? Pallis AG, Hatse S, Brouwers B, Pawelec G, Falandry C, Wedding U, Lago LD, Repetto L, Ring A, Wildiers H J Geriatr Oncol. 5(2):204-218. doi: 10.1016/j.jgo.2013.09.001. April 2014. View on PubMed.
Myeloid-Derived Suppressor Cells Predict Survival of Patients with Advanced Melanoma: Comparison with Regulatory T Cells and NY-ESO-1- or Melan-A-Specific T Cells. Weide B, Martens A, Zelba H, Stutz C, Derhovanessian E, Di Giacomo AM, Maio M and 6 others Clin Cancer Res. 20(6):1601-9. doi: 10.1158/1078-0432.CCR-13-2508. March 15, 2014. View on PubMed.
CD4:8 Ratio >5 Is Associated With a Dominant Naive T-Cell Phenotype and Impaired Physical Functioning in CMV-Seropositive Very Elderly People: Results From the BELFRAIL Study. Adriaensen W, Derhovanessian E, Vaes B, Van Pottelbergh G, Degryse JM, Pawelec G, Hamprecht K, Theeten H, Matheï C J Gerontol A Biol Sci Med Sci. :. doi: 10.1093/gerona/glu018. February 25, 2014. View on PubMed.
Better immunity in later life: a position paper. Faragher R, Frasca D, Remarque E, Pawelec G, for the ImAginE Consortium Age (Dordr). :. doi: 10.1007/s11357-014-9619-2. February 16, 2014. View on PubMed.
Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults. Turner JE, Campbell JP, Edwards KM, Howarth LJ, Pawelec G, Aldred S, Moss P, Drayson MT, Burns VE, Bosch JA Age (Dordr). 36(1):287-97. doi: 10.1007/s11357-013-9557-4. February 2014. View on PubMed.
Aging and immunity - Impact of behavioral intervention. Müller L, Pawelec G Brain Behav Immun. :. doi: 10.1016/j.bbi.2013.11.015. December 4, 2013. View on PubMed.
Immunosenenescence: Role of cytomegalovirus. Pawelec G Exp Gerontol. :. doi: 10.1016/j.exger.2013.11.010. November 28, 2013. View on PubMed.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARβ signaling. Dahl C, Christensen C, Jönsson G, Lorentzen A, Skjødt ML, Borg Å, Pawelec G, Guldberg P Mol Cancer Res. 11(10):1166-78. doi: 10.1158/1541-7786.MCR-13-0006. October 2013. View on PubMed.
A novel B cell population revealed by a CD38/CD24 gating strategy: CD38(-)CD24 (-) B cells in centenarian offspring and elderly people. Buffa S, Pellicanò M, Bulati M, Martorana A, Goldeck D, Caruso C, Pawelec G, Colonna-Romano G Age (Dordr). 35(5):2009-24. doi: 10.1007/s11357-012-9488-5. October 2013. View on PubMed.
Aging affects the proportions of T and B cells in a group of elderly men in a developing country--a pilot study from Pakistan. Alam I, Goldeck D, Larbi A, Pawelec G Age (Dordr). 35(5):1521-30. doi: 10.1007/s11357-012-9455-1. October 2013. View on PubMed.
Prothymosin α and a prothymosin α-derived peptide enhance T(H)1-type immune responses against defined HER-2/neu epitopes. Ioannou K, Derhovanessian E, Tsakiri E, Samara P, Kalbacher H, Voelter W, Trougakos IP, Pawelec G, Tsitsilonis OE BMC Immunol. 14:43. doi: 10.1186/1471-2172-14-43. September 22, 2013. View on PubMed.
Human T Cell Aging and the Impact of Persistent Viral Infections. Fülöp T, Larbi A, Pawelec G Front Immunol. 4:271. doi: 10.3389/fimmu.2013.00271. September 13, 2013. View on PubMed.
Evidence for Less Marked Potential Signs of T-Cell Immunosenescence in Centenarian Offspring Than in the General Age-Matched Population. Pellicanò M, Buffa S, Goldeck D, Bulati M, Martorana A, Caruso C, Colonna-Romano G, Pawelec G J Gerontol A Biol Sci Med Sci. :. doi: 10.1093/gerona/glt120. August 24, 2013. View on PubMed.
Age-associated alterations in γδ T-cells are present predominantly in individuals infected with Cytomegalovirus. Wistuba-Hamprecht K, Frasca D, Blomberg B, Pawelec G, Derhovanessian E Immun Ageing. 10(1):26. doi: 10.1186/1742-4933-10-26. July 3, 2013. View on PubMed.
Enhanced Chemokine Receptor Expression on Leukocytes of Patients with Alzheimer's Disease. Goldeck D, Larbi A, Pellicanó M, Alam I, Zerr I, Schmidt C, Fulop T, Pawelec G PLoS One. 8(6):e66664. doi: 10.1371/journal.pone.0066664. June 18, 2013. View on PubMed.
Immunosenescence in vertebrates and invertebrates. Müller L, Fülöp T, Pawelec G Immun Ageing. 10(1):12. doi: 10.1186/1742-4933-10-12. April 2, 2013. View on PubMed.
Cohort Profile: The Berlin Aging Study II (BASE-II). Bertram L, Böckenhoff A, Demuth I, Düzel S, Eckardt R, Li SC, Lindenberger U and 4 others Int J Epidemiol. :. doi: 10.1093/ije/dyt018. March 14, 2013. View on PubMed.
Multi-parametric phospho-flow cytometry: a crucial tool for T lymphocyte signaling studies. Goldeck D, Low I, Shadan NB, Mustafah S, Pawelec G, Larbi A Cytometry A. 83(3):265-72. doi: 10.1002/cyto.a.22252. March 2013. View on PubMed.
Hsps are up-regulated in melanoma tissue and correlate with patient clinical parameters. Shipp C, Weide B, Derhovanessian E, Pawelec G Cell Stress Chaperones. 18(2):145-54. doi: 10.1007/s12192-012-0363-1. March 2013. View on PubMed.
An investigation of the effects of the antioxidants, ebselen or N-acetyl cysteine on human peripheral blood mononuclear cells and T cells. Marthandan S, Hyland P, Pawelec G, Barnett Y Immun Ageing. 10(1):7. doi: 10.1186/1742-4933-10-7. February 21, 2013. View on PubMed.
16(th) IHIW: immunogenetics of aging. Naumova E, Ivanova M, Pawelec G, Constantinescu I, Bogunia-Kubik K, Lange A, Oguz F and 5 others Int J Immunogenet. 40(1):77-81. doi: 10.1111/iji.12027. February 2013. View on PubMed.
Gene expression analysis of mTOR pathway: association with human longevity. Passtoors WM, Beekman M, Deelen J, van der Breggen R, Maier AB, Guigas B, Derhovanessian E and 5 others Aging Cell. 12(1):24-31. doi: 10.1111/acel.12015. February 2013. View on PubMed.
Immunology of aging and cancer development. Fulop T, Larbi A, Kotb R, Pawelec G Interdiscip Top Gerontol. 38:38-48. doi: 10.1159/000343599. January 17, 2013. View on PubMed.
Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination. Derhovanessian E, Theeten H, Hähnel K, Van Damme P, Cools N, Pawelec G Vaccine. 31(4):685-90. doi: 10.1016/j.vaccine.2012.11.041. January 11, 2013. View on PubMed.
Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 2: new immune paradigm. Fulop T, Lacombe G, Cunnane S, Le Page A, Dupuis G, Frost EH, Bourgade-Navarro K, Goldeck D, Larbi A, Pawelec G Discov Med. 15(80):33-42. January 2013. View on PubMed.
Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 1: clinical and historical background. Fulop T, Lacombe G, Cunnane S, Le Page A, Dupuis G, Frost EH, Bourgade-Navarro K, Goldeck D, Larbi A, Pawelec G Discov Med. 15(80):23-32. January 2013. View on PubMed.
A consideration of biomarkers to be used for evaluation of inflammation in human nutritional studies. Calder PC, Ahluwalia N, Albers R, Bosco N, Bourdet-Sicard R, Haller D, Holgate ST and 10 others Br J Nutr. 109 Suppl 1:S1-34. doi: 10.1017/S0007114512005119. January 2013. View on PubMed.
Immunosenescence and cancer. Fulop T, Larbi A, Witkowski JM, Kotb R, Hirokawa K, Pawelec G Crit Rev Oncog. 18(6):489-513. 2013. View on PubMed.
CMV and Immunosenescence: from basics to clinics. Solana R, Tarazona R, Aiello AE, Akbar AN, Appay V, Beswick M, Bosch JA and 30 others Immun Ageing. 9(1):23. doi: 10.1186/1742-4933-9-23. October 31, 2012. View on PubMed.
Cancer classification using the Immunoscore: a worldwide task force. Galon J, Pagès F, Marincola FM, Angell HK, Thurin M, Lugli A, Zlobec I and 57 others J Transl Med. 10:205. doi: 10.1186/1479-5876-10-205. October 3, 2012. View on PubMed.
The nascent field of AllergoOncology. Jensen-Jarolim E, Pawelec G Cancer Immunol Immunother. 61(9):1355-7. doi: 10.1007/s00262-012-1315-4. September 2012. View on PubMed.
Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study. Chen S, de Craen AJ, Raz Y, Derhovanessian E, Vossen AC, Westendorp RG, Pawelec G, Maier AB Immun Ageing. 9(1):18. doi: 10.1186/1742-4933-9-18. August 28, 2012. View on PubMed.
Nutritional status influences peripheral immune cell phenotypes in healthy men in rural Pakistan. Alam I, Larbi A, Pawelec G Immun Ageing. 9(1):16. doi: 10.1186/1742-4933-9-16. August 3, 2012. View on PubMed.
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Walter S, Weinschenk T, Stenzl A, Zdrojowy R, Pluzanska A, Szczylik C, Staehler M and 32 others Nat Med. 18(8):1254-61. doi: 10.1038/nm.2883. August 2012. View on PubMed.
T cell assays and MIATA: the essential minimum for maximum impact. Britten CM, Janetzki S, Butterfield LH, Ferrari G, Gouttefangeas C, Huber C, Kalos M and 16 others Immunity. 37(1):1-2. doi: 10.1016/j.immuni.2012.07.010. July 27, 2012. View on PubMed.
Hallmarks of human "immunosenescence": adaptation or dysregulation? Pawelec G Immun Ageing. 9(1):15. doi: 10.1186/1742-4933-9-15. July 25, 2012. View on PubMed.
Effect of culture at low oxygen tension on the expression of heat shock proteins in a panel of melanoma cell lines. Shipp C, Derhovanessian E, Pawelec G PLoS One. 7(6):e37475. doi: 10.1371/journal.pone.0037475. June 22, 2012. View on PubMed.
Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people. Derhovanessian E, Maier AB, Hähnel K, Zelba H, de Craen AJ, Roelofs H, Slagboom EP, Westendorp RG, Pawelec G Age (Dordr). :. doi: 10.1007/s11357-012-9425-7. June 4, 2012. View on PubMed.
Functional T cells targeting NY-ESO-1 or Melan-A are predictive for survival of patients with distant melanoma metastasis. Weide B, Zelba H, Derhovanessian E, Pflugfelder A, Eigentler TK, Di Giacomo AM, Maio M and 7 others J Clin Oncol. 30(15):1835-41. doi: 10.1200/JCO.2011.40.2271. May 20, 2012. View on PubMed.
The impact of CMV infection on survival in older humans. Pawelec G, McElhaney JE, Aiello AE, Derhovanessian E Curr Opin Immunol. :. doi: 10.1016/j.coi.2012.04.002. April 26, 2012. View on PubMed.
The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. McElhaney JE, Zhou X, Talbot HK, Soethout E, Bleackley RC, Granville DJ, Pawelec G Vaccine. 30(12):2060-7. doi: 10.1016/j.vaccine.2012.01.015. March 9, 2012. View on PubMed.
Immune profiling of Alzheimer patients. Pellicanò M, Larbi A, Goldeck D, Colonna-Romano G, Buffa S, Bulati M, Rubino G and 5 others J Neuroimmunol. 242(1-2):52-9. doi: 10.1016/j.jneuroim.2011.11.005. January 18, 2012. View on PubMed.
Defining the critical hurdles in cancer immunotherapy. Fox BA, Schendel DJ, Butterfield LH, Aamdal S, Allison JP, Ascierto PA, Atkins MB and 98 others J Transl Med. 9(1):214. doi: 10.1186/1479-5876-9-214. December 14, 2011. View on PubMed.
Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans. Derhovanessian E, Maier AB, Hähnel K, Beck R, de Craen AJ, Slagboom EP, Westendorp RG, Pawelec G J Gen Virol. 92(Pt 12):2746-56. doi: 10.1099/vir.0.036004-0. December 2011. View on PubMed.
Report from the Second Cytomegalovirus and Immunosenescence Workshop. Wills M, Akbar A, Beswick M, Bosch JA, Caruso C, Colonna-Romano G, Dutta A and 32 others Immun Ageing. 8(1):10. doi: 10.1186/1742-4933-8-10. October 28, 2011. View on PubMed.
Aging, immunity, and cancer. Fulop T, Larbi A, Kotb R, de Angelis F, Pawelec G Discov Med. 11(61):537-50. June 2011. View on PubMed.
Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers. Butterfield LH, Palucka AK, Britten CM, Dhodapkar MV, Håkansson L, Janetzki S, Kawakami Y and 26 others Clin Cancer Res. 17(10):3064-76. doi: 10.1158/1078-0432.CCR-10-2234. May 15, 2011. View on PubMed.
Association of IFN-gamma signal transduction defects with impaired HLA class I antigen processing in melanoma cell lines. Respa A, Bukur J, Ferrone S, Pawelec G, Zhao Y, Wang E, Marincola FM, Seliger B Clin Cancer Res. 17(9):2668-78. doi: 10.1158/1078-0432.CCR-10-2114. May 1, 2011. View on PubMed.
'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop. Naumova E, Ivanova M, Pawelec G, Constantinescu I, Bogunia-Kubik K, Lange A, Qguz F and 4 others Tissue Antigens. 77(3):187-92. doi: 10.1111/j.1399-0039.2010.01603.x. March 2011. View on PubMed.
Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. Simanek AM, Dowd JB, Pawelec G, Melzer D, Dutta A, Aiello AE PLoS One. 6(2):e16103. doi: 10.1371/journal.pone.0016103. February 17, 2011. View on PubMed.
Minimal information about T cell assays: the process of reaching the community of T cell immunologists in cancer and beyond. Britten CM, Janetzki S, van der Burg SH, Huber C, Kalos M, Levitsky HI, Maecker HT and 9 others Cancer Immunol Immunother. 60(1):15-22. doi: 10.1007/s00262-010-0940-z. January 2011. View on PubMed.
Hallmark features of immunosenescence are absent in familial longevity. Derhovanessian E, Maier AB, Beck R, Jahn G, Hähnel K, Slagboom PE, de Craen AJ, Westendorp RG, Pawelec G J Immunol. 185(8):4618-24. doi: 10.4049/jimmunol.1001629. October 15, 2010. View on PubMed.
Aging, frailty and age-related diseases. Fulop T, Larbi A, Witkowski JM, McElhaney J, Loeb M, Mitnitski A, Pawelec G Biogerontology. 11(5):547-63. doi: 10.1007/s10522-010-9287-2. October 2010. View on PubMed.
Immunosenescence and Cytomegalovirus: where do we stand after a decade? Pawelec G, Akbar A, Beverley P, Caruso C, Derhovanessian E, Fülöp T, Griffiths P and 13 others Immun Ageing. 7:13. doi: 10.1186/1742-4933-7-13. September 7, 2010. View on PubMed.
Epigenetic and immune function profiles associated with posttraumatic stress disorder. Uddin M, Aiello AE, Wildman DE, Koenen KC, Pawelec G, de Los Santos R, Goldmann E, Galea S Proc Natl Acad Sci U S A. 107(20):9470-5. doi: 10.1073/pnas.0910794107. May 18, 2010. View on PubMed.
Induction of HIF-1alpha and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells. Larbi A, Zelba H, Goldeck D, Pawelec G J Leukoc Biol. 87(2):265-73. doi: 10.1189/jlb.0509304. February 2010. View on PubMed.
Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation. Larbi A, Cabreiro F, Zelba H, Marthandan S, Combet E, Friguet B, Petropoulos I, Barnett Y, Pawelec G Free Radic Biol Med. 48(1):26-34. doi: 10.1016/j.freeradbiomed.2009.09.025. January 1, 2010. View on PubMed.
Simultaneous infiltration of polyfunctional effector and suppressor T cells into renal cell carcinomas. Attig S, Hennenlotter J, Pawelec G, Klein G, Koch SD, Pircher H, Feyerabend S and 4 others Cancer Res. 69(21):8412-9. doi: 10.1158/0008-5472.CAN-09-0852. November 1, 2009. View on PubMed.
Accumulations of KIR+ T cells in the elderly. Pawelec G Blood. 114(16):3360-1. doi: 10.1182/blood-2009-08-235259. October 15, 2009. View on PubMed.
Pretreatment frequency of circulating IL-17+ CD4+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients. Derhovanessian E, Adams V, Hähnel K, Groeger A, Pandha H, Ward S, Pawelec G Int J Cancer. 125(6):1372-9. doi: 10.1002/ijc.24497. September 15, 2009. View on PubMed.
The European searchable tumour line database. Robinson J, Roberts CH, Dodi IA, Madrigal JA, Pawelec G, Wedel L, Marsh SG Cancer Immunol Immunother. 58(9):1501-6. doi: 10.1007/s00262-008-0656-5. September 2009. View on PubMed.
Biomarkers of human immunosenescence: impact of Cytomegalovirus infection. Derhovanessian E, Larbi A, Pawelec G Curr Opin Immunol. 21(4):440-5. doi: 10.1016/j.coi.2009.05.012. August 2009. View on PubMed.
Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients. Weide B, Pascolo S, Scheel B, Derhovanessian E, Pflugfelder A, Eigentler TK, Pawelec G, Hoerr I, Rammensee HG, Garbe C J Immunother. 32(5):498-507. doi: 10.1097/CJI.0b013e3181a00068. June 2009. View on PubMed.
Immunosenescence and vaccination in nursing home residents. Fulop T, Pawelec G, Castle S, Loeb M Clin Infect Dis. 48(4):443-8. doi: 10.1086/596475. February 15, 2009. View on PubMed.
Special issue on cancer and ageing. Pawelec G, Bohr V, Campisi J Mech Ageing Dev. 130(1-2):1-2. doi: 10.1016/j.mad.2008.11.002. February 2009. View on PubMed.
Prothymosin alpha immunoactive carboxyl-terminal peptide TKKQKTDEDD stimulates lymphocyte reactions, induces dendritic cell maturation and adopts a beta-sheet conformation in a sequence-specific manner. Skopeliti M, Iconomidou VA, Derhovanessian E, Pawelec G, Voelter W, Kalbacher H, Hamodrakas SJ, Tsitsilonis OE Mol Immunol. 46(5):784-92. doi: 10.1016/j.molimm.2008.09.014. February 2009. View on PubMed.
NKp80 defines and stimulates a reactive subset of CD8 T cells. Kuttruff S, Koch S, Kelp A, Pawelec G, Rammensee HG, Steinle A Blood. 113(2):358-69. doi: 10.1182/blood-2008-03-145615. January 8, 2009. View on PubMed.
Cytomegalovirus and human immunosenescence. Pawelec G, Derhovanessian E, Larbi A, Strindhall J, Wikby A Rev Med Virol. 19(1):47-56. doi: 10.1002/rmv.598. January 2009. View on PubMed.
Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people. Koch S, Larbi A, Derhovanessian E, Ozcelik D, Naumova E, Pawelec G Immun Ageing. 5:6. doi: 10.1186/1742-4933-5-6. July 25, 2008. View on PubMed.
Characterization of HLA class I altered phenotypes in a panel of human melanoma cell lines. Méndez R, Rodríguez T, Del Campo A, Monge E, Maleno I, Aptsiauri N, Jiménez P and 4 others Cancer Immunol Immunother. 57(5):719-29. doi: 10.1007/s00262-007-0411-3. May 2008. View on PubMed.
Aging of the immune system as a prognostic factor for human longevity. Larbi A, Franceschi C, Mazzatti D, Solana R, Wikby A, Pawelec G Physiology (Bethesda). 23:64-74. doi: 10.1152/physiol.00040.2007. April 2008. View on PubMed.
Are cancer and ageing different sides of the same coin? Conference on Cancer and Ageing. Pawelec G, Solana R EMBO Rep. 9(3):234-8. doi: 10.1038/embor.2008.12. March 2008. View on PubMed.
The CIMT-monitoring panel: a two-step approach to harmonize the enumeration of antigen-specific CD8+ T lymphocytes by structural and functional assays. Britten CM, Gouttefangeas C, Welters MJ, Pawelec G, Koch S, Ottensmeier C, Mander A and 17 others Cancer Immunol Immunother. 57(3):289-302. doi: 10.1007/s00262-007-0378-0. March 2008. View on PubMed.
HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptides. Mathieu MG, Knights AJ, Pawelec G, Riley CL, Wernet D, Lemonnier FA, Straten PT, Mueller L, Rees RC, McArdle SE Cancer Immunol Immunother. 56(12):1885-95. doi: 10.1007/s00262-007-0331-2. December 2007. View on PubMed.
No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study. Strindhall J, Nilsson BO, Löfgren S, Ernerudh J, Pawelec G, Johansson B, Wikby A Exp Gerontol. 42(8):753-61. doi: 10.1016/j.exger.2007.05.001. August 2007. View on PubMed.
SELDI-TOF-MS ProteinChip array profiling of T-cell clones propagated in long-term culture identifies human profilin-1 as a potential bio-marker of immunosenescence. Mazzatti DJ, Pawelec G, Longdin R, Powell JR, Forsey RJ Proteome Sci. 5:7. doi: 10.1186/1477-5956-5-7. June 5, 2007. View on PubMed.
Gene expression changes in long-term culture of T-cell clones: genomic effects of chronic antigenic stress in aging and immunosenescence. Mazzatti DJ, White A, Forsey RJ, Powell JR, Pawelec G Aging Cell. 6(2):155-63. doi: 10.1111/j.1474-9726.2007.00269.x. April 2007. View on PubMed.
Immunosenescence comes of age. Symposium on Aging Research in Immunology: The Impact of Genomics. Pawelec G EMBO Rep. 8(3):220-3. doi: 10.1038/sj.embor.7400922. March 2007. View on PubMed.
The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning. Wikby A, Nilsson BO, Forsey R, Thompson J, Strindhall J, Löfgren S, Ernerudh J, Pawelec G, Ferguson F, Johansson B Mech Ageing Dev. 127(8):695-704. doi: 10.1016/j.mad.2006.04.003. August 2006. View on PubMed.
A novel MHC-associated proteinase 3 peptide isolated from primary chronic myeloid leukaemia cells further supports the significance of this antigen for the immunotherapy of myeloid leukaemias. Knights AJ, Weinzierl AO, Flad T, Guinn BA, Mueller L, Mufti GJ, Stevanovic S, Pawelec G Leukemia. 20(6):1067-72. doi: 10.1038/sj.leu.2404234. June 2006. View on PubMed.
Aging and innate immunity. Solana R, Pawelec G, Tarazona R Immunity. 24(5):491-4. doi: 10.1016/j.immuni.2006.05.003. May 2006. View on PubMed.
Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. Hadrup SR, Strindhall J, Køllgaard T, Seremet T, Johansson B, Pawelec G, thor Straten P, Wikby A J Immunol. 176(4):2645-53. February 15, 2006. View on PubMed.
High frequencies of functionally impaired cytokeratin 18-specific CD8+ T cells in healthy HLA-A2+ donors. Walter S, Bioley G, Bühring HJ, Koch S, Wernet D, Zippelius A, Pawelec G and 4 others Eur J Immunol. 35(10):2876-85. doi: 10.1002/eji.200526207. October 2005. View on PubMed.
Human immunosenescence: is it infectious? Pawelec G, Akbar A, Caruso C, Solana R, Grubeck-Loebenstein B, Wikby A Immunol Rev. 205:257-68. doi: 10.1111/j.0105-2896.2005.00271.x. June 2005. View on PubMed.
An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. Wikby A, Ferguson F, Forsey R, Thompson J, Strindhall J, Löfgren S, Nilsson BO, Ernerudh J, Pawelec G, Johansson B J Gerontol A Biol Sci Med Sci. 60(5):556-65. May 2005. View on PubMed.
Is immunosenescence infectious? Pawelec G, Akbar A, Caruso C, Effros R, Grubeck-Loebenstein B, Wikby A Trends Immunol. 25(8):406-10. doi: 10.1016/j.it.2004.05.006. August 2004. View on PubMed.
Age related microsatellite instability in T cells from healthy individuals. Krichevsky S, Pawelec G, Gural A, Effros RB, Globerson A, Yehuda DB, Yehuda AB Exp Gerontol. 39(4):507-15. doi: 10.1016/j.exger.2003.12.016. April 2004. View on PubMed.
Microsatellite instability in in vitro ageing of T lymphocyte clones. Neri S, Cattini L, Facchini A, Pawelec G, Mariani E Exp Gerontol. 39(4):499-505. doi: 10.1016/j.exger.2003.11.017. April 2004. View on PubMed.
Development of an MHC-class I peptide selection assay combining nanoparticle technology and matrix-assisted laser desorption/ionisation mass spectrometry. Flad T, Schiestel T, Brunner H, Tolson J, Ouyang Q, Pawelec G, Mueller GA, Mueller CA, Tovar GE, Beck H J Immunol Methods. 283(1-2):205-13. December 2003. View on PubMed.
Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - a biochemical paradigm for the ageing immune system. Fülöp T Jr, Larbi A, Dupuis G, Pawelec G Arthritis Res Ther. 5(6):290-302. doi: 10.1186/ar1019. October 16, 2003. View on PubMed.
Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Ouyang Q, Wagner WM, Voehringer D, Wikby A, Klatt T, Walter S, Müller CA, Pircher H, Pawelec G Exp Gerontol. 38(8):911-20. August 2003. View on PubMed.
Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. Ouyang Q, Wagner WM, Wikby A, Walter S, Aubert G, Dodi AI, Travers P, Pawelec G J Clin Immunol. 23(4):247-57. July 2003. View on PubMed.
An age-related increase in the number of CD8+ T cells carrying receptors for an immunodominant Epstein-Barr virus (EBV) epitope is counteracted by a decreased frequency of their antigen-specific responsiveness. Ouyang Q, Wagner WM, Walter S, Müller CA, Wikby A, Aubert G, Klatt T, Stevanovic S, Dodi T, Pawelec G Mech Ageing Dev. 124(4):477-85. April 2003. View on PubMed.
Peptides spanning the fusion region of Abl/Bcr are immunogenic and sensitize CD8(+) T lymphocytes to recognize native chronic myelogenous leukemia. Wagner WM, Ouyang Q, Pawelec G Leukemia. 16(11):2341-3. doi: 10.1038/sj.leu.2402687. November 2002. View on PubMed.
Is human immunosenescence clinically relevant? Looking for 'immunological risk phenotypes'. Pawelec G, Ouyang Q, Colonna-Romano G, Candore G, Lio D, Caruso C Trends Immunol. 23(7):330-2. July 2002. View on PubMed.
Peptide HER2(776-788) represents a naturally processed broad MHC class II-restricted T cell epitope. Sotiriadou R, Perez SA, Gritzapis AD, Sotiropoulou PA, Echner H, Heinzel S, Mamalaki A and 4 others Br J Cancer. 85(10):1527-34. doi: 10.1054/bjoc.2001.2089. November 16, 2001. View on PubMed.
Immunoageing - the cause or effect of morbidity. Pawelec G, Solana R Trends Immunol. 22(7):348-9. July 2001. View on PubMed.
Defensins are dominant HLA-DR-associated self-peptides from CD34(-) peripheral blood mononuclear cells of different tumor patients (plasmacytoma, chronic myeloid leukemia). Halder TM, Blüggel M, Heinzel S, Pawelec G, Meyer HE, Kalbacher H Blood. 95(9):2890-6. May 1, 2000. View on PubMed.
Tumour-specific MHC-class-II-restricted responses after in vitro sensitization to synthetic peptides corresponding to gp100 and Annexin II eluted from melanoma cells. Li K, Adibzadeh M, Halder T, Kalbacher H, Heinzel S, Müller C, Zeuthen J, Pawelec G Cancer Immunol Immunother. 47(1):32-8. September 1998. View on PubMed.
Human T-cell clones in long-term culture as a model of immunosenescence. Pawelec G, Rehbein A, Haehnel K, Merl A, Adibzadeh M Immunol Rev. 160:31-42. December 1997. View on PubMed.
Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion? Effros RB, Pawelec G Immunol Today. 18(9):450-4. September 1997. View on PubMed.
Isolation of novel HLA-DR restricted potential tumor-associated antigens from the melanoma cell line FM3. Halder T, Pawelec G, Kirkin AF, Zeuthen J, Meyer HE, Kun L, Kalbacher H Cancer Res. 57(15):3238-44. August 1, 1997. View on PubMed.
The role of endogenous peptides in the direct pathway of alloreactivity to human MHC class II molecules expressed on CHO cells. Pawelec G, Adibzadeh M, Bornhak S, Friccius H, Halder T, Kalbacher H, Li K and 5 others Immunol Rev. 154:155-73. December 1996. View on PubMed.
Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human CD4+ TCR2+ cultured T cell clones. Pawelec G, Sansom D, Rehbein A, Adibzadeh M, Beckman I Exp Gerontol. 31(6):655-68. December 1996. View on PubMed.
BCR/ABL leukemia oncogene fusion peptides selectively bind to certain HLA-DR alleles and can be recognized by T cells found at low frequency in the repertoire of normal donors. Pawelec G, Max H, Halder T, Bruserud O, Merl A, da Silva P, Kalbacher H Blood. 88(6):2118-24. September 15, 1996. View on PubMed.
Effects of interleukin 10 on blast cells derived from patients with acute myelogenous leukemia. Bruserud O, Tore Gjertsen B, Brustugun OT, Bassøe CF, Nesthus I, Espen Akselsen P, Bühring HJ, Pawelec G Leukemia. 9(11):1910-20. November 1995. View on PubMed.
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