Missing Avatar

Krzysztof Hyrc

Research Assistant Professor - Alafi Neuroimaging
St. Louis Missouri, US

Position - Company  
Research Assistant Professor - Alafi Neuroimaging Washington University School of Medicine Aug 1995 - Present
Degree - University  
Ph.D, Biophysics - Jagiellonian University 1982 - 1987
Publication Info
Characterization and evaluation of two novel fluorescent sigma-2 receptor ligands as proliferation probes. Zeng C, Vangveravong S, Jones LA, Hyrc K, Chang KC, Xu J, Rothfuss JM, Goldberg MP, Hotchkiss RS, Mach RH Mol Imaging. 10(6):420-33. December 2011. View on PubMed.
Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol. D'Avanzo N, Hyrc K, Enkvetchakul D, Covey DF, Nichols CG PLoS One. 6(4):e19393. doi: 10.1371/journal.pone.0019393. April 29, 2011. View on PubMed.
Characterization and Evaluation of Two Novel Fluorescent Sigma-2 Receptor Ligands as Proliferation Probes. Zeng C, Vangveravong S, Jones LA, Hyrc K, Chang KC, Xu J, Rothfuss JM, Goldberg MP, Hotchkiss RS, Mach RH Mol Imaging. :. April 27, 2011. View on PubMed.
Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses. Crawford DC, Chang CY, Hyrc KL, Mennerick S J Neurosci. 31(3):979-91. doi: 10.1523/JNEUROSCI.4960-10.2011. January 19, 2011. View on PubMed.
Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cells. Kim E, Hyrc KL, Speck J, Salles FT, Lundberg YW, Goldberg MP, Kachar B, Warchol ME, Ornitz DM Mol Cell Neurosci. 46(3):655-61. doi: 10.1016/j.mcn.2011.01.005. January 12, 2011. View on PubMed.
Regulation of cellular calcium in vestibular supporting cells by otopetrin 1. Kim E, Hyrc KL, Speck J, Lundberg YW, Salles FT, Kachar B, Goldberg MP, Warchol ME, Ornitz DM J Neurophysiol. 104(6):3439-50. doi: 10.1152/jn.00525.2010. June 16, 2010. View on PubMed.
The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine. Zhang HX, Hyrc K, Thio LL J Physiol. 587(Pt 13):3207-20. doi: 10.1113/jphysiol.2009.168757. July 1, 2009. View on PubMed.
Cellular calcium deficiency plays a role in neuronal death caused by proteasome inhibitors. Wu S, Hyrc KL, Moulder KL, Lin Y, Warmke T, Snider BJ J Neurochem. 109(5):1225-36. doi: 10.1111/j.1471-4159.2009.06037.x. March 14, 2009. View on PubMed.
Optical suppression of seizure-like activity with an LED. Rothman SM, Perry G, Yang XF, Hyrc K, Schmidt BF Epilepsy Res. 74(2-3):201-9. doi: 10.1016/j.eplepsyres.2007.03.009. April 19, 2007. View on PubMed.
Determining calcium concentration in heterogeneous model systems using multiple indicators. Hyrc KL, Rzeszotnik Z, Kennedy BR, Goldberg MP Cell Calcium. 42(6):576-89. doi: 10.1016/j.ceca.2007.02.002. March 21, 2007. View on PubMed.
Stem cell therapy for hearing loss: Math1 overexpression in VOT-E36 cells. Liu JJ, Shin JH, Hyrc KL, Liu S, Lei D, Holley MC, Bao J Otol Neurotol. 27(3):414-21. April 2006. View on PubMed.
Ultrastructural characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death in embryonic dopaminergic neurons. Dorsey DA, Mascó DH, Dikranian K, Hyrc K, Masciotra L, Faddis B, Soriano M, Gru AA, Goldberg MP, de Erausquin GA Apoptosis. 11(4):535-44. doi: 10.1007/s10495-006-5268-y. April 2006. View on PubMed.
Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. Wang XQ, Xiao AY, Sheline C, Hyrc K, Yang A, Goldberg MP, Choi DW, Yu SP J Cell Sci. 116(Pt 10):2099-110. doi: 10.1242/jcs.00420. May 15, 2003. View on PubMed.
Nuclear translocation of nuclear transcription factor-kappa B by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors leads to transcription of p53 and cell death in dopaminergic neurons. de Erausquin GA, Hyrc K, Dorsey DA, Mamah D, Dokucu M, Mascó DH, Walton T and 5 others Mol Pharmacol. 63(4):784-90. April 2003. View on PubMed.
Covalent and noncovalent interactions mediate metabotropic glutamate receptor mGlu5 dimerization. Romano C, Miller JK, Hyrc K, Dikranian S, Mennerick S, Takeuchi Y, Goldberg MP, O'Malley KL Mol Pharmacol. 59(1):46-53. January 2001. View on PubMed.
Ionic selectivity of low-affinity ratiometric calcium indicators: mag-Fura-2, Fura-2FF and BTC. Hyrc KL, Bownik JM, Goldberg MP Cell Calcium. 27(2):75-86. doi: 10.1054/ceca.1999.0092. February 2000. View on PubMed.
Distinct roles for sodium, chloride, and calcium in excitotoxic dendritic injury and recovery. Hasbani MJ, Hyrc KL, Faddis BT, Romano C, Goldberg MP Exp Neurol. 154(1):241-58. doi: 10.1006/exnr.1998.6929. November 1998. View on PubMed.
Neuronal free calcium measurement using BTC/AM, a low affinity calcium indicator. Hyrc KL, Bownik JM, Goldberg MP Cell Calcium. 24(3):165-75. September 1998. View on PubMed.
Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. McDonald JW, Althomsons SP, Hyrc KL, Choi DW, Goldberg MP Nat Med. 4(3):291-7. March 1998. View on PubMed.
Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low-affinity fluorescent calcium indicators. Hyrc K, Handran SD, Rothman SM, Goldberg MP J Neurosci. 17(17):6669-77. September 1, 1997. View on PubMed.
Electrophoretic heterogeneity of pigmented hamster melanoma cells. Hyrc K, Wilczek A, Cieszka K Pigment Cell Res. 6(2):100-10. March 1993. View on PubMed.
The action of v-src on gap junctional permeability is modulated by pH. Hyrc K, Rose B J Cell Biol. 110(4):1217-26. April 1990. View on PubMed.
  • Krzysztof Hyrc hasn't received any ratings yet...