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Eva Rakasz

Associate Scientist - Wisconsin National Primate Research Center

Position - Company  
Associate Scientist - Wisconsin National Primate Research Center Mar 1998 - Present
Degree - University  
Ph.D., Immunology - ELTE 1998 - Present
Publication Info
A Nonfucosylated Variant of the anti-HIV-1 Monoclonal Antibody b12 Has Enhanced FcγRIIIa-Mediated Antiviral Activity In Vitro but Does Not Improve Protection against Mucosal SHIV Challenge in Macaques. Moldt B, Shibata-Koyama M, Rakasz EG, Schultz N, Kanda Y, Dunlop DC, Finstad SL and 15 others J Virol. 86(11):6189-96. doi: 10.1128/JVI.00491-12. June 2012. View on PubMed.
Dengue virus-specific CD4+ and CD8+ T lymphocytes target NS1, NS3 and NS5 in infected Indian rhesus macaques. Mladinich KM, Piaskowski SM, Rudersdorf R, Eernisse CM, Weisgrau KL, Martins MA, Furlott JR and 6 others Immunogenetics. 64(2):111-21. doi: 10.1007/s00251-011-0566-0. February 2012. View on PubMed.
GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo. Vojnov L, Martins MA, Almeida JR, Ende Z, Rakasz EG, Reynolds MR, Leon EJ and 15 others PLoS One. 6(8):e23515. doi: 10.1371/journal.pone.0023515. August 26, 2011. View on PubMed.
CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses. Neves PC, Rudersdorf RA, Galler R, Bonaldo MC, de Santana MG, Mudd PA, Martins MA, Rakasz EG, Wilson NA, Watkins DI Vaccine. 28(51):8183-8. doi: 10.1016/j.vaccine.2010.09.090. November 29, 2010. View on PubMed.
Ex vivo analysis of SIV-infected cells by flow cytometry. Reynolds MR, Piaskowski SM, Weisgrau KL, Weiler AM, Friedrich TC, Rakasz EG Cytometry A. 77(11):1059-66. doi: 10.1002/cyto.a.20960. November 2010. View on PubMed.
Macaque long-term nonprogressors resist superinfection with multiple CD8+ T cell escape variants of simian immunodeficiency virus. Weinfurter JT, May GE, Soma T, Hessell AJ, León EJ, Macnair CE, Piaskowski SM and 8 others J Virol. 85(1):530-41. doi: 10.1128/JVI.01025-10. October 20, 2010. View on PubMed.
The live-attenuated yellow fever vaccine 17D induces broad and potent T cell responses against several viral proteins in Indian rhesus macaques--implications for recombinant vaccine design. Mudd PA, Piaskowski SM, Neves PC, Rudersdorf R, Kolar HL, Eernisse CM, Weisgrau KL and 6 others Immunogenetics. 62(9):593-600. doi: 10.1007/s00251-010-0461-0. September 2010. View on PubMed.
Integrin alpha4beta7 is downregulated on the surfaces of simian immunodeficiency virus SIVmac239-infected cells. Budde ML, Lhost JJ, Dudley DM, Rakasz EG, O'Connor DH J Virol. 84(13):6344-51. doi: 10.1128/JVI.00430-10. April 21, 2010. View on PubMed.
Recombinant yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 gag induces SIV-specific CD8+ T-cell responses in rhesus macaques. Bonaldo MC, Martins MA, Rudersdorf R, Mudd PA, Sacha JB, Piaskowski SM, Costa Neves PC and 9 others J Virol. 84(7):3699-706. doi: 10.1128/JVI.02255-09. April 2010. View on PubMed.
High viremia is associated with high levels of in vivo major histocompatibility complex class I Downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239. Friedrich TC, Piaskowski SM, León EJ, Furlott JR, Maness NJ, Weisgrau KL, Mac Nair CE and 8 others J Virol. 84(10):5443-7. doi: 10.1128/JVI.02452-09. March 10, 2010. View on PubMed.
Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L. Hessell AJ, Rakasz EG, Tehrani DM, Huber M, Weisgrau KL, Landucci G, Forthal DN and 4 others J Virol. 84(3):1302-13. doi: 10.1128/JVI.01272-09. November 11, 2009. View on PubMed.
Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic. Vojnov L, Reed JS, Weisgrau KL, Rakasz EG, Loffredo JT, Piaskowski SM, Sacha JB and 4 others J Virol. 84(2):753-64. doi: 10.1128/JVI.01596-09. November 4, 2009. View on PubMed.
Infection with "escaped" virus variants impairs control of simian immunodeficiency virus SIVmac239 replication in Mamu-B*08-positive macaques. Valentine LE, Loffredo JT, Bean AT, León EJ, MacNair CE, Beal DR, Piaskowski SM and 11 others J Virol. 83(22):11514-27. doi: 10.1128/JVI.01298-09. September 2, 2009. View on PubMed.
Novel translation products from simian immunodeficiency virus SIVmac239 Env-encoding mRNA contain both Rev and cryptic T-cell epitopes. Maness NJ, Sacha JB, Piaskowski SM, Weisgrau KL, Rakasz EG, May GE, Buechler MB, Walsh AD, Wilson NA, Watkins DI J Virol. 83(19):10280-5. doi: 10.1128/JVI.00138-09. July 15, 2009. View on PubMed.
Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. Hessell AJ, Rakasz EG, Poignard P, Hangartner L, Landucci G, Forthal DN, Koff WC, Watkins DI, Burton DR PLoS Pathog. 5(5):e1000433. doi: 10.1371/journal.ppat.1000433. May 15, 2009. View on PubMed.
Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge. Wilson NA, Keele BF, Reed JS, Piaskowski SM, MacNair CE, Bett AJ, Liang X and 23 others J Virol. 83(13):6508-21. doi: 10.1128/JVI.00272-09. April 29, 2009. View on PubMed.
Macaques vaccinated with live-attenuated SIV control replication of heterologous virus. Reynolds MR, Weiler AM, Weisgrau KL, Piaskowski SM, Furlott JR, Weinfurter JT, Kaizu M and 17 others J Exp Med. 205(11):2537-50. doi: 10.1084/jem.20081524. October 27, 2008. View on PubMed.
Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239. Weiler AM, Li Q, Duan L, Kaizu M, Weisgrau KL, Friedrich TC, Reynolds MR, Haase AT, Rakasz EG J Virol. 82(8):4154-8. doi: 10.1128/JVI.01947-07. February 13, 2008. View on PubMed.
Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication. Loffredo JT, Bean AT, Beal DR, León EJ, May GE, Piaskowski SM, Furlott JR and 7 others J Virol. 82(4):1723-38. doi: 10.1128/JVI.02084-07. December 5, 2007. View on PubMed.
AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape. Maness NJ, Valentine LE, May GE, Reed J, Piaskowski SM, Soma T, Furlott J and 9 others J Exp Med. 204(11):2505-12. doi: 10.1084/jem.20071261. October 29, 2007. View on PubMed.
Recognition of escape variants in ELISPOT does not always predict CD8+ T-cell recognition of simian immunodeficiency virus-infected cells expressing the same variant sequences. Valentine LE, Piaskowski SM, Rakasz EG, Henry NL, Wilson NA, Watkins DI J Virol. 82(1):575-81. doi: 10.1128/JVI.00275-07. October 24, 2007. View on PubMed.
Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression. Sacha JB, Chung C, Rakasz EG, Spencer SP, Jonas AK, Bean AT, Lee W and 11 others J Immunol. 178(5):2746-54. March 1, 2007. View on PubMed.
Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication. Friedrich TC, Valentine LE, Yant LJ, Rakasz EG, Piaskowski SM, Furlott JR, Weisgrau KL and 8 others J Virol. 81(7):3465-76. doi: 10.1128/JVI.02392-06. January 24, 2007. View on PubMed.
The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape. Loffredo JT, Burwitz BJ, Rakasz EG, Spencer SP, Stephany JJ, Vela JP, Martin SR and 11 others J Virol. 81(6):2624-34. doi: 10.1128/JVI.01912-06. December 27, 2006. View on PubMed.
Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication. Chung C, Lee W, Loffredo JT, Burwitz B, Friedrich TC, Giraldo Vela JP, Napoe G and 4 others J Virol. 81(3):1517-23. doi: 10.1128/JVI.01780-06. November 29, 2006. View on PubMed.
Repeated intravaginal inoculation with cell-associated simian immunodeficiency virus results in persistent infection of nonhuman primates. Kaizu M, Weiler AM, Weisgrau KL, Vielhuber KA, May G, Piaskowski SM, Furlott J and 5 others J Infect Dis. 194(7):912-6. doi: 10.1086/507308. October 1, 2006. View on PubMed.
Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239. Wilson NA, Reed J, Napoe GS, Piaskowski S, Szymanski A, Furlott J, Gonzalez EJ and 26 others J Virol. 80(12):5875-85. doi: 10.1128/JVI.00171-06. June 2006. View on PubMed.
Tat(28-35)SL8-specific CD8+ T lymphocytes are more effective than Gag(181-189)CM9-specific CD8+ T lymphocytes at suppressing simian immunodeficiency virus replication in a functional in vitro assay. Loffredo JT, Rakasz EG, Giraldo JP, Spencer SP, Grafton KK, Martin SR, Napoé G, Yant LJ, Wilson NA, Watkins DI J Virol. 79(23):14986-91. doi: 10.1128/JVI.79.23.14986-14991.2005. December 2005. View on PubMed.
CD8+ T-lymphocyte response to major immunodominant epitopes after vaginal exposure to simian immunodeficiency virus: too late and too little. Reynolds MR, Rakasz E, Skinner PJ, White C, Abel K, Ma ZM, Compton L and 5 others J Virol. 79(14):9228-35. doi: 10.1128/JVI.79.14.9228-9235.2005. July 2005. View on PubMed.
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