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J David Warren

Associate Research Professor - Weill Cornell Medical College

Position - Company  
Assistant Professor - Weill Cornell Medical College Cornell University Mar 2006 - Feb 2012
Research Fellow - The Sloan-Kettering Institute for Cancer Research Nov 2002 - Mar 2006
Associate Research Professor - Weill Cornell Medical College Cornell University Mar 2012 - Present
Director - Milstein Chemistry Core Facility - Weill Cornell Medical College Cornell University Mar 2006 - Present
Degree - University  
Postdoc, Bioorganic Chemistry - Memorial Sloan-Kettering Cancer Center 2002 - 2006
Ph.D., Organic Chemistry - Colorado State University 1997 - 2002
BS, Biochemistry and Cell & Molecular Biology - Fort Lewis College 1993 - 1997
Publication Info
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC and 11 others Proc Natl Acad Sci U S A. 113(7):1778-83. doi: 10.1073/pnas.1521548113. February 16, 2016. View on PubMed.
Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis. Gold B, Roberts J, Ling Y, Quezada LL, Glasheen J, Ballinger E, Somersan-Karakaya S, Warrier T, Warren JD, Nathan C Antimicrob Agents Chemother. 59(10):6521-38. doi: 10.1128/AAC.00803-15. October 2015. View on PubMed.
Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum. Vergnolle O, Chavadi SS, Edupuganti UR, Mohandas P, Chan C, Zeng J, Kopylov M and 4 others J Bacteriol. 197(6):1040-50. doi: 10.1128/JB.02546-14. March 2015. View on PubMed.
Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome. Fan H, Angelo NG, Warren JD, Nathan CF, Lin G ACS Med Chem Lett. 5(4):405-10. doi: 10.1021/ml400531d. April 10, 2014. View on PubMed.
Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium. Nociari MM, Lehmann GL, Perez Bay AE, Radu RA, Jiang Z, Goicochea S, Schreiner R and 7 others Proc Natl Acad Sci U S A. 111(14):E1402-8. doi: 10.1073/pnas.1400530111. April 8, 2014. View on PubMed.
Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice. Lun S, Guo H, Adamson J, Cisar JS, Davis TD, Chavadi SS, Warren JD, Quadri LE, Tan DS, Bishai WR Antimicrob Agents Chemother. 57(10):5138-40. doi: 10.1128/AAC.00918-13. October 2013. View on PubMed.
Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis. Darby CM, Ingólfsson HI, Jiang X, Shen C, Sun M, Zhao N, Burns K and 6 others PLoS One. 8(7):e68942. doi: 10.1371/journal.pone.0068942. July 30, 2013. View on PubMed.
The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. Birk AV, Liu S, Soong Y, Mills W, Singh P, Warren JD, Seshan SV, Pardee JD, Szeto HH J Am Soc Nephrol. 24(8):1250-61. doi: 10.1681/ASN.2012121216. July 2013. View on PubMed.
Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Gold B, Pingle M, Brickner SJ, Shah N, Roberts J, Rundell M, Bracken WC and 16 others Proc Natl Acad Sci U S A. 109(40):16004-11. doi: 10.1073/pnas.1214188109. October 2, 2012. View on PubMed.
On the Mechanisms of Cyanine Fluorophore Photostabilization. Zheng Q, Jockusch S, Zhou Z, Altman RB, Warren JD, Turro NJ, Blanchard SC J Phys Chem Lett. 3(16):2200-2203. doi: 10.1021/jz300670p. August 16, 2012. View on PubMed.
Enhanced photostability of cyanine fluorophores across the visible spectrum. Altman RB, Zheng Q, Zhou Z, Terry DS, Warren JD, Blanchard SC Nat Methods. 9(5):428-9. doi: 10.1038/nmeth.1988. April 27, 2012. View on PubMed.
Cyanine fluorophore derivatives with enhanced photostability. Altman RB, Terry DS, Zhou Z, Zheng Q, Geggier P, Kolster RA, Zhao Y, Javitch JA, Warren JD, Blanchard SC Nat Methods. 9(1):68-71. doi: 10.1038/nmeth.1774. November 13, 2011. View on PubMed.
On the chemical mechanism of succinic semialdehyde dehydrogenase (GabD1) from Mycobacterium tuberculosis. de Carvalho LP, Ling Y, Shen C, Warren JD, Rhee KY Arch Biochem Biophys. 509(1):90-9. doi: 10.1016/j.abb.2011.01.023. May 1, 2011. View on PubMed.
Opsin is a phospholipid flippase. Menon I, Huber T, Sanyal S, Banerjee S, Barré P, Canis S, Warren JD, Hwa J, Sakmar TP, Menon AK Curr Biol. 21(2):149-53. doi: 10.1016/j.cub.2010.12.031. January 25, 2011. View on PubMed.
Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells. Rosenbaum AI, Zhang G, Warren JD, Maxfield FR Proc Natl Acad Sci U S A. 107(12):5477-82. doi: 10.1073/pnas.0914309107. March 23, 2010. View on PubMed.
Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase . Bryk R, Arango N, Venugopal A, Warren JD, Park YH, Patel MS, Lima CD, Nathan C Biochemistry. 49(8):1616-27. doi: 10.1021/bi9016186. March 2, 2010. View on PubMed.
Cooperation between a coenzyme A-independent stand-alone initiation module and an iterative type I polyketide synthase during synthesis of mycobacterial phenolic glycolipids. He W, Soll CE, Chavadi SS, Zhang G, Warren JD, Quadri LE J Am Chem Soc. 131(46):16744-50. doi: 10.1021/ja904792q. November 25, 2009. View on PubMed.
Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience. Zhu J, Warren JD, Danishefsky SJ Expert Rev Vaccines. 8(10):1399-413. doi: 10.1586/erv.09.95. October 2009. View on PubMed.
Inhibitors selective for mycobacterial versus human proteasomes. Lin G, Li D, de Carvalho LP, Deng H, Tao H, Vogt G, Wu K and 5 others Nature. 461(7264):621-6. doi: 10.1038/nature08357. October 1, 2009. View on PubMed.
Fully synthetic carbohydrate HIV antigens designed on the logic of the 2G12 antibody. Krauss IJ, Joyce JG, Finnefrock AC, Song HC, Dudkin VY, Geng X, Warren JD, Chastain M, Shiver JW, Danishefsky SJ J Am Chem Soc. 129(36):11042-4. doi: 10.1021/ja074804r. September 12, 2007. View on PubMed.
Building complex glycopeptides: Development of a cysteine-free native chemical ligation protocol. Wu B, Chen J, Warren JD, Chen G, Hua Z, Danishefsky SJ Angew Chem Int Ed Engl. 45(25):4116-25. doi: 10.1002/anie.200600538. June 19, 2006. View on PubMed.
Studies related to the relative thermodynamic stability of C-terminal peptidyl esters of O-hydroxy thiophenol: emergence of a doable strategy for non-cysteine ligation applicable to the chemical synthesis of glycopeptides. Chen G, Warren JD, Chen J, Wu B, Wan Q, Danishefsky SJ J Am Chem Soc. 128(23):7460-2. doi: 10.1021/ja061588y. June 14, 2006. View on PubMed.
Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities. Ouerfelli O, Warren JD, Wilson RM, Danishefsky SJ Expert Rev Vaccines. 4(5):677-85. doi: 10.1586/14760584.4.5.677. October 2005. View on PubMed.
Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. Warren JD, Miller JS, Keding SJ, Danishefsky SJ J Am Chem Soc. 126(21):6576-8. doi: 10.1021/ja0491836. June 2, 2004. View on PubMed.
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