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Alessandro Weisz

Director - Laboratory of Molecular Medicine and Genomics
Baronissi, IT
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Position - Company  
Professor of General Pathology - University of Salerno, Dept. of Medicine and Surgery Jan 2011 - Present
Director - Laboratory of Molecular Medicine and Genomics Jan 2011 - Present
Director - University of Salerno Hospital, Molecular Pathology and Medical Genomics Unit Mar 2011 - Present
Degree - University  
MD, Oncology, Molecular Medicine, General Pathology - University of Napoli, First Faculty of Medicine and Surgery 1974 - 1980
Publication Info
Effects of Oestrogen on MicroRNA Expression in Hormone-Responsive Breast Cancer Cells. Ferraro L, Ravo M, Nassa G, Tarallo R, De Filippo MR, Giurato G, Cirillo F and 11 others Horm Cancer. 3(3):65-78. doi: 10.1007/s12672-012-0102-1. June 2012. View on PubMed.
Preparation of two novel monobrominated 2-(2',4'-dihydroxybenzoyl)-3,4,5,6-tetrachlorobenzoic acids and their separation from crude synthetic mixtures using vortex counter-current chromatography. Weisz A, Witten JJ, Zeng Y, Mazzola EP, Ito Y J Chromatogr A. 1237:106-14. doi: 10.1016/j.chroma.2012.03.040. May 11, 2012. View on PubMed.
Signaling networks associated with AKT activation in non-small cell lung cancer (NSCLC): new insights on the role of phosphatydil-inositol-3 kinase. Scrima M, De Marco C, Fabiani F, Franco R, Pirozzi G, Rocco G, Ravo M and 6 others PLoS One. 7(2):e30427. doi: 10.1371/journal.pone.0030427. February 17, 2012. View on PubMed.
Direct regulation of microRNA biogenesis and expression by estrogen receptor beta in hormone-responsive breast cancer. Paris O, Ferraro L, Grober OM, Ravo M, De Filippo MR, Giurato G, Nassa G and 9 others Oncogene. :. doi: 10.1038/onc.2011.583. January 9, 2012. View on PubMed.
Preparative separation of 1,3,6-pyrenetrisulfonic acid trisodium salt from the color additive D&C Green No. 8 (pyranine) by pH-zone-refining counter-current chromatography. Weisz A, Mazzola EP, Ito Y J Chromatogr A. 1218(45):8249-54. doi: 10.1016/j.chroma.2011.09.049. November 11, 2011. View on PubMed.
Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3. Leoni VP, Ledda-Columbano GM, Pibiri M, Saliba C, Perra A, Kowalik MA, Grober OM and 6 others J Hepatol. 55(5):1069-78. doi: 10.1016/j.jhep.2011.02.016. November 2011. View on PubMed.
Social support for diabetes illness management: supporting adolescents and caregivers. Idalski Carcone A, Ellis DA, Weisz A, Naar-King S J Dev Behav Pediatr. 32(8):581-90. doi: 10.1097/DBP.0b013e31822c1a27. October 2011. View on PubMed.
Specific inhibition of NF-Y subunits triggers different cell proliferation defects. Benatti P, Dolfini D, Viganò A, Ravo M, Weisz A, Imbriano C Nucleic Acids Res. 39(13):5356-68. doi: 10.1093/nar/gkr128. July 2011. View on PubMed.
The duration of diarrhea and fever is associated with growth faltering in rural Malawian children aged 6-18 months. Weisz A, Meuli G, Thakwalakwa C, Trehan I, Maleta K, Manary M Nutr J. 10(1):25. doi: 10.1186/1475-2891-10-25. March 20, 2011. View on PubMed.
Comparative analysis of nuclear estrogen receptor alpha and beta interactomes in breast cancer cells. Nassa G, Tarallo R, Guzzi PH, Ferraro L, Cirillo F, Ravo M, Nola E and 5 others Mol Biosyst. 7(3):667-76. doi: 10.1039/c0mb00145g. March 2011. View on PubMed.
Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation. Grober OM, Mutarelli M, Giurato G, Ravo M, Cicatiello L, De Filippo MR, Ferraro L and 8 others BMC Genomics. 12:36. doi: 10.1186/1471-2164-12-36. January 14, 2011. View on PubMed.
Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. Tarallo R, Bamundo A, Nassa G, Nola E, Paris O, Ambrosino C, Facchiano A, Baumann M, Nyman TA, Weisz A Proteomics. 11(1):172-9. doi: 10.1002/pmic.201000217. January 2011. View on PubMed.
A large set of estrogen receptor β-interacting proteins identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei. Nassa G, Tarallo R, Ambrosino C, Bamundo A, Ferraro L, Paris O, Ravo M and 6 others Proteomics. 11(1):159-65. doi: 10.1002/pmic.201000344. January 2011. View on PubMed.
The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. Carlini F, Ridolfi B, Molinari A, Parisi C, Bozzuto G, Toccacieli L, Formisano G and 8 others PLoS One. 5(12):e14221. doi: 10.1371/journal.pone.0014221. December 3, 2010. View on PubMed.
The p63 target HBP1 is required for skin differentiation and stratification. Borrelli S, Candi E, Hu B, Dolfini D, Ravo M, Grober OM, Weisz A and 4 others Cell Death Differ. 17(12):1896-907. doi: 10.1038/cdd.2010.59. December 2010. View on PubMed.
C/EBPδ gene targets in human keratinocytes. Borrelli S, Fanoni D, Dolfini D, Alotto D, Ravo M, Grober OM, Weisz A and 4 others PLoS One. 5(11):e13789. doi: 10.1371/journal.pone.0013789. November 2, 2010. View on PubMed.
Epigenetic alteration of microRNAs in DNMT3B-mutated patients of ICF syndrome. Gatto S, Della Ragione F, Cimmino A, Strazzullo M, Fabbri M, Mutarelli M, Ferraro L, Weisz A, D'Esposito M, Matarazzo MR Epigenetics. 5(5):427-43. July 1, 2010. View on PubMed.
Identification of a hormone-regulated dynamic nuclear actin network associated with estrogen receptor alpha in human breast cancer cell nuclei. Ambrosino C, Tarallo R, Bamundo A, Cuomo D, Franci G, Nassa G, Paris O and 9 others Mol Cell Proteomics. 9(6):1352-67. doi: 10.1074/mcp.M900519-MCP200. June 2010. View on PubMed.
Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs. Cicatiello L, Mutarelli M, Grober OM, Paris O, Ferraro L, Ravo M, Tarallo R and 8 others Am J Pathol. 176(5):2113-30. doi: 10.2353/ajpath.2010.090837. May 2010. View on PubMed.
Molecular bases of copper and iron deficiency-associated dyslipidemia: a microarray analysis of the rat intestinal transcriptome. Tosco A, Fontanella B, Danise R, Cicatiello L, Grober OM, Ravo M, Weisz A, Marzullo L Genes Nutr. 5(1):1-8. doi: 10.1007/s12263-009-0153-2. March 2010. View on PubMed.
Pharmacogenomics and analogues of the antitumour agent N6-isopentenyladenosine. Colombo F, Falvella FS, De Cecco L, Tortoreto M, Pratesi G, Ciuffreda P, Ottria R and 4 others Int J Cancer. 124(9):2179-85. doi: 10.1002/ijc.24168. May 1, 2009. View on PubMed.
Identification of new genes associated with breast cancer progression by gene expression analysis of predefined sets of neoplastic tissues. Cimino D, Fuso L, Sfiligoi C, Biglia N, Ponzone R, Maggiorotto F, Russo G and 5 others Int J Cancer. 123(6):1327-38. doi: 10.1002/ijc.23660. September 15, 2008. View on PubMed.
Quantitative expression profiling of highly degraded RNA from formalin-fixed, paraffin-embedded breast tumor biopsies by oligonucleotide microarrays. Ravo M, Mutarelli M, Ferraro L, Grober OM, Paris O, Tarallo R, Vigilante A and 5 others Lab Invest. 88(4):430-40. doi: 10.1038/labinvest.2008.11. April 2008. View on PubMed.
Time-course analysis of genome-wide gene expression data from hormone-responsive human breast cancer cells. Mutarelli M, Cicatiello L, Ferraro L, Grober OM, Ravo M, Facchiano AM, Angelini C, Weisz A BMC Bioinformatics. 9 Suppl 2:S12. doi: 10.1186/1471-2105-9-S2-S12. March 26, 2008. View on PubMed.
Influence of estrogens and antiestrogens on the expression of selected hormone-responsive genes. Sismondi P, Biglia N, Ponzone R, Fuso L, Scafoglio C, Cicatiello L, Ravo M and 5 others Maturitas. 57(1):50-5. doi: 10.1016/j.maturitas.2007.02.019. May 20, 2007. View on PubMed.
Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. Scafoglio C, Ambrosino C, Cicatiello L, Altucci L, Ardovino M, Bontempo P, Medici N and 11 others J Cell Biochem. 98(5):1163-84. doi: 10.1002/jcb.20820. August 1, 2006. View on PubMed.
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nebbioso A, Clarke N, Voltz E, Germain E, Ambrosino C, Bontempo P, Alvarez R and 7 others Nat Med. 11(1):77-84. doi: 10.1038/nm1161. January 2005. View on PubMed.
Molecular identification of ERalpha-positive breast cancer cells by the expression profile of an intrinsic set of estrogen regulated genes. Weisz A, Basile W, Scafoglio C, Altucci L, Bresciani F, Facchiano A, Sismondi P, Cicatiello L, De Bortoli M J Cell Physiol. 200(3):440-50. doi: 10.1002/jcp.20039. September 2004. View on PubMed.
Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 t Cicatiello L, Addeo R, Sasso A, Altucci L, Petrizzi VB, Borgo R, Cancemi M and 7 others Mol Cell Biol. 24(16):7260-74. doi: 10.1128/MCB.24.16.7260-7274.2004. August 2004. View on PubMed.
A genomic view of estrogen actions in human breast cancer cells by expression profiling of the hormone-responsive transcriptome. Cicatiello L, Scafoglio C, Altucci L, Cancemi M, Natoli G, Facchiano A, Iazzetti G and 7 others J Mol Endocrinol. 32(3):719-75. June 2004. View on PubMed.
Malignant mammary cells acquire independence from extracellular context for regulation of estrogen receptor alpha. Novaro V, Radisky DC, Ramos Castro NE, Weisz A, Bissell MJ Clin Cancer Res. 10(1 Pt 2):402S-9S. January 1, 2004. View on PubMed.
Distinct signaling pathways mediate stimulation of cell cycle progression and prevention of apoptotic cell death by estrogen in rat pituitary tumor PR1 cells. Caporali S, Imai M, Altucci L, Cancemi M, Caristi S, Cicatiello L, Matarese F and 4 others Mol Biol Cell. 14(12):5051-9. doi: 10.1091/mbc.E03-05-0303. December 2003. View on PubMed.
Identification of genes involved in growth inhibition of breast cancer cells transduced with estrogen receptor. Licznar A, Caporali S, Lucas A, Weisz A, Vignon F, Lazennec G FEBS Lett. 553(3):445-50. October 23, 2003. View on PubMed.
Quantitative real-time RT-PCR analysis of eight novel estrogen-regulated genes in breast cancer. Sorbello V, Fuso L, Sfiligoi C, Scafoglio C, Ponzone R, Biglia N, Weisz A, Sismondi P, De Bortoli M Int J Biol Markers. 18(2):123-9. June 2003. View on PubMed.
Distinct nongenomic signal transduction pathways controlled by 17beta-estradiol regulate DNA synthesis and cyclin D(1) gene transcription in HepG2 cells. Marino M, Acconcia F, Bresciani F, Weisz A, Trentalance A Mol Biol Cell. 13(10):3720-9. doi: 10.1091/mbc.E02-03-0153. October 2002. View on PubMed.
Effects of nitric oxide donors on vascular endothelial growth factor gene induction. Kimura H, Ogura T, Kurashima Y, Weisz A, Esumi H Biochem Biophys Res Commun. 296(4):976-82. August 30, 2002. View on PubMed.
17beta-estradiol inhibits forskolin-induced vascular endothelial growth factor promoter in MCF-7 breast adenocarcinoma cells. Bermont L, Lamielle-Musard F, Chezy E, Weisz A, Adessi GL J Steroid Biochem Mol Biol. 78(4):343-9. October 2001. View on PubMed.
Estrogens do not modify MAP kinase-dependent nuclear signaling during stimulation of early G(1) progression in human breast cancer cells. Caristi S, Galera JL, Matarese F, Imai M, Caporali S, Cancemi M, Altucci L and 4 others Cancer Res. 61(17):6360-6. September 1, 2001. View on PubMed.
Cell type-specific induction of cyclin D and cyclin-dependent kinase inhibitor p27(kip1) expression by estrogen in rat endometrium. Zhuang YH, Sarca D, Weisz A, Altucci L, Cicatiello L, Rollerova E, Tuohimaa P, Ylikomi T J Steroid Biochem Mol Biol. 78(2):193-9. August 2001. View on PubMed.
Inhibition of human breast cancer cell growth by blockade of the mevalonate-protein prenylation pathway is not prevented by overexpression of cyclin D1. Germano D, Pacilio C, Cancemi M, Cicatiello L, Altucci L, Petrizzi VB, Sperandio C and 5 others Breast Cancer Res Treat. 67(1):23-33. May 2001. View on PubMed.
Increased vascular endothelial growth factor 165 binding to kinase insert domain-containing receptor after infection of human endothelial cells by recombinant adenovirus encoding the Vegf(165) gene. Weisz A, Koren B, Cohen T, Neufeld G, Kleinberger T, Lewis BS, Flugelman MY Circulation. 103(14):1887-92. April 10, 2001. View on PubMed.
Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. Kimura H, Weisz A, Ogura T, Hitomi Y, Kurashima Y, Hashimoto K, D'Acquisto F, Makuuchi M, Esumi H J Biol Chem. 276(3):2292-8. doi: 10.1074/jbc.M008398200. January 19, 2001. View on PubMed.
Insulin up-regulates vascular endothelial growth factor and stabilizes its messengers in endometrial adenocarcinoma cells. Bermont L, Lamielle F, Lorchel F, Fauconnet S, Esumi H, Weisz A, Adessi GL J Clin Endocrinol Metab. 86(1):363-8. doi: 10.1210/jcem.86.1.7153. January 2001. View on PubMed.
The antiestrogen ICI 182,780 inhibits proliferation of human breast cancer cells by interfering with multiple, sequential estrogen-regulated processes required for cell cycle completion. Cicatiello L, Addeo R, Altucci L, Belsito Petrizzi V, Boccia V, Cancemi M, Germano D and 4 others Mol Cell Endocrinol. 165(1-2):199-209. July 25, 2000. View on PubMed.
Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Kimura H, Weisz A, Kurashima Y, Hashimoto K, Ogura T, D'Acquisto F, Addeo R, Makuuchi M, Esumi H Blood. 95(1):189-97. January 1, 2000. View on PubMed.
Regulation of vascular endothelial growth factor expression by insulin-like growth factor-I in endometrial adenocarcinoma cells. Bermont L, Lamielle F, Fauconnet S, Esumi H, Weisz A, Adessi GL Int J Cancer. 85(1):117-23. January 1, 2000. View on PubMed.
ERE environment- and cell type-specific transcriptional effects of estrogen in normal endometrial cells. Lascombe I, Sallot M, Vuillermoz C, Weisz A, Adessi GL, Jouvenot M Mol Cell Endocrinol. 139(1-2):153-60. April 30, 1998. View on PubMed.
Constitutive overexpression of cyclin D1 does not prevent inhibition of hormone-responsive human breast cancer cell growth by antiestrogens. Pacilio C, Germano D, Addeo R, Altucci L, Petrizzi VB, Cancemi M, Cicatiello L and 5 others Cancer Res. 58(5):871-6. March 1, 1998. View on PubMed.
Inhibition of inducible nitric oxide synthase gene expression by glucocorticoid-induced protein(s) in lipopolysaccharide-stimulated J774 cells. D'Acquisto F, Cicatiello L, Iuvone T, Ialenti A, Ianaro A, Esumi H, Weisz A, Carnuccio R Eur J Pharmacol. 339(1):87-95. November 19, 1997. View on PubMed.
Estrogen induces early and timed activation of cyclin-dependent kinases 4, 5, and 6 and increases cyclin messenger ribonucleic acid expression in rat uterus. Altucci L, Addeo R, Cicatiello L, Germano D, Pacilio C, Battista T, Cancemi M, Petrizzi VB, Bresciani F, Weisz A Endocrinology. 138(3):978-84. doi: 10.1210/endo.138.3.5002. March 1997. View on PubMed.
17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells. Altucci L, Addeo R, Cicatiello L, Dauvois S, Parker MG, Truss M, Beato M, Sica V, Bresciani F, Weisz A Oncogene. 12(11):2315-24. June 6, 1996. View on PubMed.
Regulation of the mouse inducible-type nitric oxide synthase gene promoter by interferon-gamma, bacterial lipopolysaccharide and NG-monomethyl-L-arginine. Weisz A, Cicatiello L, Esumi H Biochem J. 316 ( Pt 1):209-15. May 15, 1996. View on PubMed.
Stimulation of human breast cancer MCF-7 cells with estrogen prevents cell cycle arrest by HMG-CoA reductase inhibitors. Addeo R, Altucci L, Battista T, Bonapace IM, Cancemi M, Cicatiello L, Germano D and 4 others Biochem Biophys Res Commun. 220(3):864-70. doi: 10.1006/bbrc.1996.0494. March 27, 1996. View on PubMed.
17 beta-Estradiol overcomes a G1 block induced by HMG-CoA reductase inhibitors and fosters cell cycle progression without inducing ERK-1 and -2 MAP kinases activation. Bonapace IM, Addeo R, Altucci L, Cicatiello L, Bifulco M, Laezza C, Salzano S, Sica V, Bresciani F, Weisz A Oncogene. 12(4):753-63. February 15, 1996. View on PubMed.
Implication of nitric oxide synthase in carcinogenesis: analysis of the human inducible nitric oxide synthase gene. Esumi H, Ogura T, Kurashima Y, Adachi H, Hokari A, Weisz A Pharmacogenetics. 5 Spec No:S166-70. 1995. View on PubMed.
Inducible nitric oxide synthase in a human glioblastoma cell line. Fujisawa H, Ogura T, Hokari A, Weisz A, Yamashita J, Esumi H J Neurochem. 64(1):85-91. January 1995. View on PubMed.
Dual mechanism for the control of inducible-type NO synthase gene expression in macrophages during activation by interferon-gamma and bacterial lipopolysaccharide. Transcriptional and post-transcriptional regulation. Weisz A, Oguchi S, Cicatiello L, Esumi H J Biol Chem. 269(11):8324-33. March 18, 1994. View on PubMed.
Enhancement of inducible-type NO synthase gene transcription by protein synthesis inhibitors. Activation of an intracellular signal transduction pathway by low concentrations of cycloheximide. Oguchi S, Weisz A, Esumi H FEBS Lett. 338(3):326-30. February 7, 1994. View on PubMed.
Functional antagonism between the estrogen receptor and Fos in the regulation of c-fos protooncogene transcription. Ambrosino C, Cicatiello L, Cobellis G, Addeo R, Sica V, Bresciani F, Weisz A Mol Endocrinol. 7(11):1472-83. doi: 10.1210/mend.7.11.8114761. November 1993. View on PubMed.
Estrogen regulation of proto-oncogenes coding for nuclear proteins. Weisz A, Bresciani F Crit Rev Oncog. 4(4):361-88. 1993. View on PubMed.
Identification of a specific pattern of "immediate-early" gene activation induced by estrogen during mitogenic stimulation of rat uterine cells. Cicatiello L, Sica V, Bresciani F, Weisz A Receptor. 3(1):17-30. 1993. View on PubMed.
Transcriptional activation of jun and actin genes by estrogen during mitogenic stimulation of rat uterine cells. Cicatiello L, Ambrosino C, Coletta B, Scalona M, Sica V, Bresciani F, Weisz A J Steroid Biochem Mol Biol. 41(3-8):523-8. March 1992. View on PubMed.
Estrogen induces c-fos expression specifically in the luminal and glandular epithelia of adult rat uterus. Papa M, Mezzogiorno V, Bresciani F, Weisz A Biochem Biophys Res Commun. 175(2):480-5. March 15, 1991. View on PubMed.
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