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Jakob Wikstrom

Position - Company  
MD PhD - Karolinska University Hospital 2017 - 2017
Degree - University  
Ph.D., Physiology - Stockholm University 2008 - 2010
M.D., medicine - Uppsala University 2000 - 2005
Publication Info
A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets. Wikstrom JD, Sereda SB, Stiles L, Elorza A, Allister EM, Neilson A, Ferrick DA, Wheeler MB, Shirihai OS PLoS One. 7(5):e33023. doi: 10.1371/journal.pone.0033023. May 14, 2012. View on PubMed.
Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Gilkerson RW, De Vries RL, Lebot P, Wikstrom JD, Torgyekes E, Shirihai OS, Przedborski S, Schon EA Hum Mol Genet. 21(5):978-90. doi: 10.1093/hmg/ddr529. March 1, 2012. View on PubMed.
Fatty acids suppress autophagic turnover in β-cells. Las G, Serada SB, Wikstrom JD, Twig G, Shirihai OS J Biol Chem. 286(49):42534-44. doi: 10.1074/jbc.M111.242412. December 9, 2011. View on PubMed.
Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion. Robson-Doucette CA, Sultan S, Allister EM, Wikstrom JD, Koshkin V, Bhattacharjee A, Prentice KJ, Sereda SB, Shirihai OS, Wheeler MB Diabetes. 60(11):2710-9. doi: 10.2337/db11-0132. November 2011. View on PubMed.
Screening for active small molecules in mitochondrial complex I deficient patient's fibroblasts, reveals AICAR as the most beneficial compound. Golubitzky A, Dan P, Weissman S, Link G, Wikstrom JD, Saada A PLoS One. 6(10):e26883. doi: 10.1371/journal.pone.0026883. October 26, 2011. View on PubMed.
Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity. Twig G, Liu X, Liesa M, Wikstrom JD, Molina AJ, Las G, Yaniv G, Hajnóczky G, Shirihai OS Am J Physiol Cell Physiol. 299(2):C477-87. doi: 10.1152/ajpcell.00427.2009. August 2010. View on PubMed.
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A and 13 others Cell. 140(2):280-93. doi: 10.1016/j.cell.2009.12.041. January 22, 2010. View on PubMed.
Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G and 4 others Diabetes. 58(10):2303-15. doi: 10.2337/db07-1781. October 2009. View on PubMed.
What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy? Wikstrom JD, Twig G, Shirihai OS Int J Biochem Cell Biol. 41(10):1914-27. doi: 10.1016/j.biocel.2009.06.006. October 2009. View on PubMed.
Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR and 15 others Nat Med. 14(2):144-53. doi: 10.1038/nm1717. February 2008. View on PubMed.
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L and 10 others EMBO J. 27(2):433-46. doi: 10.1038/sj.emboj.7601963. January 23, 2008. View on PubMed.
beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ and 5 others Diabetes. 56(10):2569-78. doi: 10.2337/db06-0757. October 2007. View on PubMed.
PA-GFP: a window into the subcellular adventures of the individual mitochondrion. Haigh SE, Twig G, Molina AA, Wikstrom JD, Deutsch M, Shirihai OS Novartis Found Symp. 287:21-36; discussion 36-46. 2007. View on PubMed.
Tagging and tracking individual networks within a complex mitochondrial web with photoactivatable GFP. Twig G, Graf SA, Wikstrom JD, Mohamed H, Haigh SE, Elorza A, Deutsch M, Zurgil N, Reynolds N, Shirihai OS Am J Physiol Cell Physiol. 291(1):C176-84. doi: 10.1152/ajpcell.00348.2005. July 2006. View on PubMed.
Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells. Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE Am J Physiol Endocrinol Metab. 290(1):E143-E148. doi: 10.1152/ajpendo.00216.2005. January 2006. View on PubMed.
Mitochondrial metabolism reveals a functional architecture in intact islets of Langerhans from normal and diabetic Psammomys obesus. Katzman SM, Messerli MA, Barry DT, Grossman A, Harel T, Wikstrom JD, Corkey BE, Smith PJ, Shirihai OS Am J Physiol Endocrinol Metab. 287(6):E1090-9. doi: 10.1152/ajpendo.00044.2004. December 2004. View on PubMed.
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