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Rena Feinman

Associate Professor - Department of Surgery

Position - Company  
Associate Professor - Department of Surgery University of Medicine and Dentistry of New Jersey - New Jersey Medical School 2011 - Present
Degree - University  
PhD, Basic Medical Sciences - Show of Hands Mobile Polling 1983 - 1988
Publication Info
Activation of TLR4 is Necessary for Trauma Hemorrhagic Shock-Induced Gut Injury and PMN Priming. Reino DC, Palange D, Feketeova E, Bonitz RP, Xu DZ, Lu Q, Sheth SU and 4 others Shock. :. doi: 10.1097/SHK.0b013e318257123a. May 9, 2012. View on PubMed.
Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice. Reino DC, Pisarenko V, Palange D, Doucet D, Bonitz RP, Lu Q, Colorado I and 7 others PLoS One. 6(8):e14829. doi: 10.1371/journal.pone.0014829. August 4, 2011. View on PubMed.
Anticoagulants influence the in vitro activity and composition of shock lymph but not its in vivo activity. Deitch EA, Qin X, Sheth SU, Tiesi G, Palange D, Dong W, Lu Q, Xu D, Feketeova E, Feinman R Shock. 36(2):177-83. doi: 10.1097/SHK.0b013e3182205c30. August 2011. View on PubMed.
Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. Kannan KB, Colorado I, Reino D, Palange D, Lu Q, Qin X, Abungu B and 6 others Am J Physiol Gastrointest Liver Physiol. 300(5):G853-61. doi: 10.1152/ajpgi.00459.2010. December 23, 2010. View on PubMed.
HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury. Feinman R, Deitch EA, Watkins AC, Abungu B, Colorado I, Kannan KB, Sheth SU and 10 others Am J Physiol Gastrointest Liver Physiol. 299(4):G833-43. doi: 10.1152/ajpgi.00065.2010. August 5, 2010. View on PubMed.
Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats. Doucet D, Badami C, Palange D, Bonitz RP, Lu Q, Xu DZ, Kannan KB, Colorado I, Feinman R, Deitch EA PLoS One. 5(2):e9421. doi: 10.1371/journal.pone.0009421. February 25, 2010. View on PubMed.
Estrogenic hormone modulation abrogates changes in red blood cell deformability and neutrophil activation in trauma hemorrhagic shock. Doucet DR, Bonitz RP, Feinman R, Colorado I, Ramanathan M, Feketeova E, Condon M and 4 others J Trauma. 68(1):35-41. doi: 10.1097/TA.0b013e3181bbbddb. January 2010. View on PubMed.
Saturated fat and vascular compliance. Feinman R J Am Diet Assoc. 109(9):1524-5; author reply 1525, 1527. doi: 10.1016/j.jada.2009.07.034. September 2009. View on PubMed.
Trauma-hemorrhagic shock-induced pulmonary epithelial and endothelial cell injury utilizes different programmed cell death signaling pathways. Barlos D, Deitch EA, Watkins AC, Caputo FJ, Lu Q, Abungu B, Colorado I, Xu DZ, Feinman R Am J Physiol Lung Cell Mol Physiol. 296(3):L404-17. doi: 10.1152/ajplung.00491.2007. December 31, 2008. View on PubMed.
Mesenteric lymph duct ligation improves survival in a lethal shock model. Badami CD, Senthil M, Caputo FJ, Rupani BJ, Doucet D, Pisarenko V, Xu DZ, Lu Q, Feinman R, Deitch EA Shock. 30(6):680-5. doi: 10.1097/SHK.0b013e318173edd1. December 2008. View on PubMed.
Intravenous injection of trauma-hemorrhagic shock mesenteric lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway. Senthil M, Watkins A, Barlos D, Xu DZ, Lu Q, Abungu B, Caputo F, Feinman R, Deitch EA Ann Surg. 246(5):822-30. doi: 10.1097/SLA.0b013e3180caa3af. November 2007. View on PubMed.
The female intestine is more resistant than the male intestine to gut injury and inflammation when subjected to conditions associated with shock states. Homma H, Hoy E, Xu DZ, Lu Q, Feinman R, Deitch EA Am J Physiol Gastrointest Liver Physiol. 288(3):G466-72. doi: 10.1152/ajpgi.00036.2004. October 21, 2004. View on PubMed.
Persistent HIF-1alpha activation in gut ischemia/reperfusion injury: potential role of bacteria and lipopolysaccharide. Koury J, Deitch EA, Homma H, Abungu B, Gangurde P, Condon MR, Lu Q, Xu DZ, Feinman R Shock. 22(3):270-7. September 2004. View on PubMed.
RIP kinase is involved in arsenic-induced apoptosis in multiple myeloma cells. Bajenova O, Tang B, Pearse R, Feinman R, Childs BH, Michaeli J Apoptosis. 9(5):561-71. doi: 10.1023/B:APPT.0000038030.47068.49. September 2004. View on PubMed.
Regulation of NF-kB in multiple myeloma: therapeutic implications. Feinman R, Siegel DS, Berenson J Clin Adv Hematol Oncol. 2(3):162-6. March 2004. View on PubMed.
Phenylbutyrate-induced apoptosis is associated with inactivation of NF-kappaB IN HT-29 colon cancer cells. Feinman R, Clarke KO, Harrison LE Cancer Chemother Pharmacol. 49(1):27-34. January 2002. View on PubMed.
Tributyrin, an oral butyrate analogue, induces apoptosis through the activation of caspase-3. Clarke KO, Feinman R, Harrison LE Cancer Lett. 171(1):57-65. September 28, 2001. View on PubMed.
Changes in E2F binding after phenylbutyrate-induced differentiation of Caco-2 colon cancer cells. Wang QM, Feinman R, Kashanchi F, Houghton JM, Studzinski GP, Harrison LE Clin Cancer Res. 6(7):2951-8. July 2000. View on PubMed.
Role of NF-kappaB in the rescue of multiple myeloma cells from glucocorticoid-induced apoptosis by bcl-2. Feinman R, Koury J, Thames M, Barlogie B, Epstein J, Siegel DS Blood. 93(9):3044-52. May 1, 1999. View on PubMed.
Hexamethylene bisacetamide induces programmed cell death (apoptosis) and down-regulates BCL-2 expression in human myeloma cells. Siegel DS, Zhang X, Feinman R, Teitz T, Zelenetz A, Richon VM, Rifkind RA, Marks PA, Michaeli J Proc Natl Acad Sci U S A. 95(1):162-6. January 6, 1998. View on PubMed.
Combinatorial determinants of tissue-specific transcription in B cells and macrophages. Nikolajczyk BS, Cortes M, Feinman R, Sen R Mol Cell Biol. 17(7):3527-35. July 1997. View on PubMed.
Cytogenetics and molecular genetics in multiple myeloma. Feinman R, Sawyer J, Hardin J, Tricot G Hematol Oncol Clin North Am. 11(1):1-25. February 1997. View on PubMed.
Myc/max family of transcription factors and bcl-2 are involved in drug-induced apoptosis of myeloma cells. Siegel DS, Terry JA, Koury J, Barlogie B, Epstein J, Feinman R Curr Top Microbiol Immunol. 224:257-60. 1997. View on PubMed.
Biology and therapy of multiple myeloma in 1996. Barlogie B, Jagannath S, Epstein J, Munshi N, Siegel D, Desikan KR, Feinman R, Hsu PL, von Bremen K, Tricot G Semin Hematol. 34(1 Suppl 1):67-72. January 1997. View on PubMed.
PU.1 and an HLH family member contribute to the myeloid-specific transcription of the Fc gamma RIIIA promoter. Feinman R, Qiu WQ, Pearse RN, Nikolajczyk BS, Sen R, Sheffery M, Ravetch JV EMBO J. 13(16):3852-60. August 15, 1994. View on PubMed.
Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3. Pearse RN, Feinman R, Shuai K, Darnell JE Jr, Ravetch JV Proc Natl Acad Sci U S A. 90(9):4314-8. May 1, 1993. View on PubMed.
Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements. Pearse RN, Feinman R, Ravetch JV Proc Natl Acad Sci U S A. 88(24):11305-9. December 15, 1991. View on PubMed.
Mechanisms and significance of the mitogenic and antiviral actions of TNF. Vilcek J, Palombella VJ, Zhang Y, Lin JX, Feinman R, Reis LF, Le J Ann Inst Pasteur Immunol. 139(3):307-11. June 1988. View on PubMed.
Differential effects of type I IFN and IFN-gamma on the binding of tumor necrosis factor to receptors in two human cell lines. Tsujimoto M, Feinman R, Vilcek J J Immunol. 137(7):2272-6. October 1, 1986. View on PubMed.
Characterization and affinity crosslinking of receptors for tumor necrosis factor on human cells. Tsujimoto M, Feinman R, Kohase M, Vilcek J Arch Biochem Biophys. 249(2):563-8. September 1986. View on PubMed.
Interferon-gamma enhances target cell sensitivity to monocyte killing. Feinman R, Siegel DS, Le JM, Vilcek J Cell Immunol. 99(1):287-93. April 15, 1986. View on PubMed.
Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors. Vilcek J, Palombella VJ, Henriksen-DeStefano D, Swenson C, Feinman R, Hirai M, Tsujimoto M J Exp Med. 163(3):632-43. March 1, 1986. View on PubMed.
Antigen non-specific activities in culture supernatant of ovalbumin-specific, cloned helper T lymphoma. Yefenof E, Feinman R, Kedar E Immunobiology. 169(5):520-31. July 1985. View on PubMed.
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