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Kai Hilpert

Researcher (PI) - Karlsruhe Institut of Technology (KIT)

Position - Company  
Researcher (PI) - Karlsruhe Institut of Technology (KIT) 2012 - Present
Degree - University  
Ph.D., Biochemistry - Humboldt University 1997 - 2001
Publication Info
A Novel Monoclonal Antibody Against the C-terminus of β-Tubulin Recognizes Endocytic Organelles in Trypanosoma cruzi. Cornejo A, Oliveira CR, Wurtele M, Chung J, Hilpert K, Schenkman S Protein Pept Lett. 19(6):636-43. June 1, 2012. View on PubMed.
The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides. Gao G, Lange D, Hilpert K, Kindrachuk J, Zou Y, Cheng JT, Kazemzadeh-Narbat M and 7 others Biomaterials. 32(16):3899-909. doi: 10.1016/j.biomaterials.2011.02.013. March 5, 2011. View on PubMed.
SPOT synthesis as a tool to study protein-protein interactions. Winkler DF, Andresen H, Hilpert K Methods Mol Biol. 723:105-27. doi: 10.1007/978-1-61779-043-0_8. 2011. View on PubMed.
Structural studies of a peptide with immune modulating and direct antimicrobial activity. Wieczorek M, Jenssen H, Kindrachuk J, Scott WR, Elliott M, Hilpert K, Cheng JT, Hancock RE, Straus SK Chem Biol. 17(9):970-80. doi: 10.1016/j.chembiol.2010.07.007. September 24, 2010. View on PubMed.
Screening for antifungal peptides and their modes of action in Aspergillus nidulans. Mania D, Hilpert K, Ruden S, Fischer R, Takeshita N Appl Environ Microbiol. 76(21):7102-8. doi: 10.1128/AEM.01560-10. September 10, 2010. View on PubMed.
Short cationic antimicrobial peptides interact with ATP. Hilpert K, McLeod B, Yu J, Elliott MR, Rautenbach M, Ruden S, Bürck J and 4 others Antimicrob Agents Chemother. 54(10):4480-3. doi: 10.1128/AAC.01664-09. July 26, 2010. View on PubMed.
Easy strategy to protect antimicrobial peptides from fast degradation in serum. Knappe D, Henklein P, Hoffmann R, Hilpert K Antimicrob Agents Chemother. 54(9):4003-5. doi: 10.1128/AAC.00300-10. June 28, 2010. View on PubMed.
High-throughput screening for antimicrobial peptides using the SPOT technique. Hilpert K Methods Mol Biol. 618:125-33. doi: 10.1007/978-1-60761-594-1_9. 2010. View on PubMed.
Synthesis of antimicrobial peptides using the SPOT technique. Winkler DF, Hilpert K Methods Mol Biol. 618:111-24. doi: 10.1007/978-1-60761-594-1_8. 2010. View on PubMed.
Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides. Ruden S, Hilpert K, Berditsch M, Wadhwani P, Ulrich AS Antimicrob Agents Chemother. 53(8):3538-40. doi: 10.1128/AAC.01106-08. June 15, 2009. View on PubMed.
Identification of novel antibacterial peptides by chemoinformatics and machine learning. Fjell CD, Jenssen H, Hilpert K, Cheung WA, Panté N, Hancock RE, Cherkasov A J Med Chem. 52(7):2006-15. doi: 10.1021/jm8015365. April 9, 2009. View on PubMed.
Screening and characterization of surface-tethered cationic peptides for antimicrobial activity. Hilpert K, Elliott M, Jenssen H, Kindrachuk J, Fjell CD, Körner J, Winkler DF and 8 others Chem Biol. 16(1):58-69. doi: 10.1016/j.chembiol.2008.11.006. January 30, 2009. View on PubMed.
Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. Cherkasov A, Hilpert K, Jenssen H, Fjell CD, Waldbrook M, Mullaly SC, Volkmer R, Hancock RE ACS Chem Biol. 4(1):65-74. doi: 10.1021/cb800240j. January 16, 2009. View on PubMed.
Synthesis of peptide arrays using SPOT-technology and the CelluSpots-method. Winkler DF, Hilpert K, Brandt O, Hancock RE Methods Mol Biol. 570:157-74. doi: 10.1007/978-1-60327-394-7_5. 2009. View on PubMed.
Identification of novel host defense peptides and the absence of alpha-defensins in the bovine genome. Fjell CD, Jenssen H, Fries P, Aich P, Griebel P, Hilpert K, Hancock RE, Cherkasov A Proteins. 73(2):420-30. doi: 10.1002/prot.22059. November 1, 2008. View on PubMed.
X-ray spectromicroscopy study of competitive adsorption of protein and peptide onto polystyrene-poly(methyl methacrylate). Leung BO, Hitchcock AP, Brash JL, Scholl A, Doran A, Henklein P, Overhage J, Hilpert K, Hale JD, Hancock RE Biointerphases. 3(2):FB27. doi: 10.1116/1.2956637. June 2008. View on PubMed.
Short linear cationic antimicrobial peptides: screening, optimizing, and prediction. Hilpert K, Fjell CD, Cherkasov A Methods Mol Biol. 494:127-59. doi: 10.1007/978-1-59745-419-3_8. 2008. View on PubMed.
Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances. Wiegand I, Hilpert K, Hancock RE Nat Protoc. 3(2):163-75. doi: 10.1038/nprot.2007.521. 2008. View on PubMed.
Evaluating different descriptors for model design of antimicrobial peptides with enhanced activity toward P. aeruginosa. Jenssen H, Lejon T, Hilpert K, Fjell CD, Cherkasov A, Hancock RE Chem Biol Drug Des. 70(2):134-42. doi: 10.1111/j.1747-0285.2007.00543.x. August 2007. View on PubMed.
Using intrinsic X-ray absorption spectral differences to identify and map peptides and proteins. Stewart-Ornstein J, Hitchcock AP, Hernández Cruz D, Henklein P, Overhage J, Hilpert K, Hale JD, Hancock RE J Phys Chem B. 111(26):7691-9. doi: 10.1021/jp0720993. July 5, 2007. View on PubMed.
Use of luminescent bacteria for rapid screening and characterization of short cationic antimicrobial peptides synthesized on cellulose using peptide array technology. Hilpert K, Hancock RE Nat Protoc. 2(7):1652-60. doi: 10.1038/nprot.2007.203. 2007. View on PubMed.
Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion. Hilpert K, Winkler DF, Hancock RE Nat Protoc. 2(6):1333-49. doi: 10.1038/nprot.2007.160. 2007. View on PubMed.
Sequence requirements and an optimization strategy for short antimicrobial peptides. Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE Chem Biol. 13(10):1101-7. doi: 10.1016/j.chembiol.2006.08.014. October 2006. View on PubMed.
Complete substitutional analysis of a sunflower trypsin inhibitor with different serine proteases. Hilpert K, Hansen G, Wessner H, Volkmer-Engert R, Höhne W J Biochem. 138(4):383-90. doi: 10.1093/jb/mvi140. October 2005. View on PubMed.
High-throughput generation of small antibacterial peptides with improved activity. Hilpert K, Volkmer-Engert R, Walter T, Hancock RE Nat Biotechnol. 23(8):1008-12. doi: 10.1038/nbt1113. July 24, 2005. View on PubMed.
Unraveling sub-site specificities of peptidic serine protease inhibitors by substitutional and structural analysis. Höhne W, Hilpert K Protein Pept Lett. 12(5):449-56. July 2005. View on PubMed.
Crystallization and preliminary x-ray analysis of complexes of porcine pancreatic elastase with two natural inhibitors. Hilpert K, Wessner H, Scholz C, Scheerer P, Volkmer-Engert R, Kraubeta N Protein Pept Lett. 11(4):393-9. August 2004. View on PubMed.
Design and characterization of a hybrid miniprotein that specifically inhibits porcine pancreatic elastase. Hilpert K, Wessner H, Schneider-Mergener J, Welfle K, Misselwitz R, Welfle H, Hocke AC, Hippenstiel S, Höhne W J Biol Chem. 278(27):24986-93. doi: 10.1074/jbc.M212152200. July 4, 2003. View on PubMed.
Structure of a hybrid squash inhibitor in complex with porcine pancreatic elastase at 1.8 A resolution. Aÿ J, Hilpert K, Krauss N, Schneider-Mergener J, Höhne W Acta Crystallogr D Biol Crystallogr. 59(Pt 2):247-54. January 23, 2003. View on PubMed.
Crystallization and preliminary X-ray analysis of the complex of porcine pancreatic elastase and a hybrid squash inhibitor. Hilpert K, Schneider-Mergener J, Aÿ J Acta Crystallogr D Biol Crystallogr. 58(Pt 4):672-4. March 22, 2002. View on PubMed.
Anti-c-myc antibody 9E10: epitope key positions and variability characterized using peptide spot synthesis on cellulose. Hilpert K, Hansen G, Wessner H, Küttner G, Welfle K, Seifert M, Höhne W Protein Eng. 14(10):803-6. October 2001. View on PubMed.
Characterizing and optimizing protease/peptide inhibitor interactions, a new application for spot synthesis. Hilpert K, Hansen G, Wessner H, Schneider-Mergener J, Höhne W J Biochem. 128(6):1051-7. December 2000. View on PubMed.
Atomic resolution structure of native porcine pancreatic elastase at 1.1 A. Würtele M, Hahn M, Hilpert K, Höhne W Acta Crystallogr D Biol Crystallogr. 56(Pt 4):520-3. April 2000. View on PubMed.
Interaction of the capsid protein p24 (HIV-1) with sequence-derived peptides: influence on p24 dimerization. Hilpert K, Behlke J, Scholz C, Misselwitz R, Schneider-Mergener J, Höhne W Virology. 254(1):6-10. doi: 10.1006/viro.1998.9526. February 1, 1999. View on PubMed.
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