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Sridar Chittur

Director, Microarray Core - DNA Microarray Core Facility
Rensselaer New York, US

Position - Company  
Director, Microarray Core - DNA Microarray Core Facility Center for Functional Genomics

The Center for Functional Genomics (CFG) maintains a comprehensive state-of-the-art research facility to support a wide range of services that are offered on a fee-per service basis to commercial and academic organizations.

We are able to coordinate efforts among our different Facilities so that we can accommodate researchers in projects from start to finish. For example, the CFG (http://www.albany.edu/genomics/)is able to isolate genes, design and make DNA constructs through our Molecular Biology Facility, then coordinate with the Mouse Transgenic Facility to make Transgenic or Knock-out mice and then the mice generated can be analyzed at the DNA, RNA or Protein levels through our Molecular Biology, Microarray, Laser Capture Microdissection or Proteomics Facilities.

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2000 - Present
Degree - University  
PhD, Pharmaceutical Sciences (Medicinal Chemistry) - West Virginia University 1991 - 1996
BPharm, Pharmacy - Bombay University 1987 - 1991
Publication Info
Induction of STEAP4 correlates with 1,25-dihydroxyvitamin D3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue. Narvaez CJ, Simmons KM, Brunton J, Salinero A, Chittur SV, Welsh JE J Cell Physiol. 228(10):2024-36. doi: 10.1002/jcp.24371. October 2013. View on PubMed.
Substrate Activation and Conformational Dynamics of Guanosine 5'-Monophosphate Synthetase. Oliver JC, Linger RS, Chittur SV, Davisson VJ Biochemistry. :. doi: 10.1021/bi3017075. July 23, 2013. View on PubMed.
Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase and induce apoptosis in inflammatory breast cancer cells. Chatterjee N, Wang WL, Conklin T, Chittur S, Tenniswood M Cancer Biol Ther. 14(7):. doi: 10.4161/cbt.25088. June 21, 2013. View on PubMed.
Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks. Shirode AB, Kovvuru P, Chittur SV, Henning SM, Heber D, Reliene R Mol Carcinog. :. doi: 10.1002/mc.21995. January 28, 2013. View on PubMed.
Genomic and metabolic responses to methionine-restricted and methionine-restricted, cysteine-supplemented diets in Fischer 344 rat inguinal adipose tissue, liver and quadriceps muscle. Perrone CE, Mattocks DA, Plummer JD, Chittur SV, Mohney R, Vignola K, Orentreich DS, Orentreich N J Nutrigenet Nutrigenomics. 5(3):132-57. doi: 10.1159/000339347. October 9, 2012. View on PubMed.
Thrombospondin-1 type 1 repeats in a model of inflammatory bowel disease: transcript profile and therapeutic effects. Lopez-Dee ZP, Chittur SV, Patel B, Stanton R, Wakeley M, Lippert B, Menaker A, Eiche B, Terry R, Gutierrez LS PLoS One. 7(4):e34590. doi: 10.1371/journal.pone.0034590. April 3, 2012. View on PubMed.
Gene expression during normal and FSHD myogenesis. Tsumagari K, Chang SC, Lacey M, Baribault C, Chittur SV, Sowden J, Tawil R, Crawford GE, Ehrlich M BMC Med Genomics. 4:67. doi: 10.1186/1755-8794-4-67. September 27, 2011. View on PubMed.
Keratinocyte expression of calcitonin gene-related peptide β: implications for neuropathic and inflammatory pain mechanisms. Hou Q, Barr T, Gee L, Vickers J, Wymer J, Borsani E, Rodella L and 10 others Pain. 152(9):2036-51. doi: 10.1016/j.pain.2011.04.033. September 2011. View on PubMed.
Inhibition of inflammatory gene expression in keratinocytes using a composition containing carnitine, thioctic Acid and saw palmetto extract. Chittur S, Parr B, Marcovici G Evid Based Complement Alternat Med. 2011:985345. doi: 10.1093/ecam/nep102. June 8, 2011. View on PubMed.
Effects of 1α,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Wang WL, Chatterjee N, Chittur SV, Welsh J, Tenniswood MP Mol Cancer. 10:58. doi: 10.1186/1476-4598-10-58. May 18, 2011. View on PubMed.
A user's guide to the encyclopedia of DNA elements (ENCODE). ENCODE Project Consortium PLoS Biol. 9(4):e1001046. doi: 10.1371/journal.pbio.1001046. April 2011. View on PubMed.
Autophagy-dependent regulation of the DNA damage response protein ribonucleotide reductase 1. Dyavaiah M, Rooney JP, Chittur SV, Lin Q, Begley TJ Mol Cancer Res. 9(4):462-75. doi: 10.1158/1541-7786.MCR-10-0473. April 2011. View on PubMed.
Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization. Gorski JP, Huffman NT, Chittur S, Midura RJ, Black C, Oxford J, Seidah NG J Biol Chem. 286(3):1836-49. doi: 10.1074/jbc.M110.151647. January 21, 2011. View on PubMed.
RIP-Chip analysis: RNA-Binding Protein Immunoprecipitation-Microarray (Chip) Profiling. Jain R, Devine T, George AD, Chittur SV, Baroni TE, Penalva LO, Tenenbaum SA Methods Mol Biol. 703:247-63. doi: 10.1007/978-1-59745-248-9_17. 2011. View on PubMed.
Metamorphosis and the regenerative capacity of spinal cord axons in Xenopus laevis. Gibbs KM, Chittur SV, Szaro BG Eur J Neurosci. 33(1):9-25. doi: 10.1111/j.1460-9568.2010.07477.x. January 2011. View on PubMed.
Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers. Mousa SA, Sudha T, Dyskin E, Dier U, Gallati C, Hanko C, Chittur SV, Rebbaa A Cancer Lett. 289(2):208-16. doi: 10.1016/j.canlet.2009.08.018. March 28, 2010. View on PubMed.
RIP-CHIP in drug development. Jain R, Doyle F, George AD, Kuentzel M, Frank D, Chittur SV, Tenenbaum SA Methods Mol Biol. 632:159-71. doi: 10.1007/978-1-60761-663-4_10. 2010. View on PubMed.
Determination of alternate splicing events using the Affymetrix Exon 1.0 ST arrays. Subbaram S, Kuentzel M, Frank D, Dipersio CM, Chittur SV Methods Mol Biol. 632:63-72. doi: 10.1007/978-1-60761-663-4_4. 2010. View on PubMed.
Decreased triadin and increased calstabin2 expression in Great Danes with dilated cardiomyopathy. Oyama MA, Chittur SV, Reynolds CA J Vet Intern Med. 23(5):1014-9. doi: 10.1111/j.1939-1676.2009.0360.x. October 2009. View on PubMed.
Comparative analysis of protein-protein interactions in cancer-associated genes. Guda P, Chittur SV, Guda C Genomics Proteomics Bioinformatics. 7(1-2):25-36. doi: 10.1016/S1672-0229(08)60030-3. June 2009. View on PubMed.
Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism. Chittur SV, Sangster-Guity N, McCormick PJ BMC Genomics. 9:507. doi: 10.1186/1471-2164-9-507. October 29, 2008. View on PubMed.
Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency. Oyama MA, Reiken S, Lehnart SE, Chittur SV, Meurs KM, Stern J, Marks AR J Vet Cardiol. 10(1):1-10. doi: 10.1016/j.jvc.2008.04.003. June 2008. View on PubMed.
Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin. Stoecklin G, Tenenbaum SA, Mayo T, Chittur SV, George AD, Baroni TE, Blackshear PJ, Anderson P J Biol Chem. 283(17):11689-99. doi: 10.1074/jbc.M709657200. April 25, 2008. View on PubMed.
Microarray analysis in B cells among siblings with/without MS - role for transcription factor TCF2. Avasarala JR, Chittur SV, George AD, Tine JA BMC Med Genomics. 1:2. doi: 10.1186/1755-8794-1-2. January 31, 2008. View on PubMed.
Method for conducting microarray study of oxidative stress induced gene expression. Subbaram S, Melendez JA, Chittur SV Methods Mol Biol. 477:357-68. doi: 10.1007/978-1-60327-517-0_27. 2008. View on PubMed.
Advances in RIP-chip analysis : RNA-binding protein immunoprecipitation-microarray profiling. Baroni TE, Chittur SV, George AD, Tenenbaum SA Methods Mol Biol. 419:93-108. doi: 10.1007/978-1-59745-033-1_6. 2008. View on PubMed.
Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease. Oyama MA, Chittur SV Am J Vet Res. 67(8):1307-18. doi: 10.2460/ajvr.67.8.1307. August 2006. View on PubMed.
Global gene expression profiles associated with retinoic acid-induced differentiation of embryonal carcinoma cells. Eifert C, Sangster-Guity N, Yu LM, Chittur SV, Perez AV, Tine JA, McCormick PJ Mol Reprod Dev. 73(7):796-824. doi: 10.1002/mrd.20444. July 2006. View on PubMed.
Cerebellar granule cell death induced by aluminum. Tuneva J, Chittur S, Boldyrev AA, Birman I, Carpenter DO Neurotox Res. 9(4):297-304. June 2006. View on PubMed.
NF-kappa B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Di Marco S, Mazroui R, Dallaire P, Chittur S, Tenenbaum SA, Radzioch D, Marette A, Gallouzi IE Mol Cell Biol. 25(15):6533-45. doi: 10.1128/MCB.25.15.6533-6545.2005. August 2005. View on PubMed.
Genomic expression patterns of cardiac tissues from dogs with dilated cardiomyopathy. Oyama MA, Chittur S Am J Vet Res. 66(7):1140-55. July 2005. View on PubMed.
Rodent lymphocytes express functionally active glutamate receptors. Boldyrev AA, Kazey VI, Leinsoo TA, Mashkina AP, Tyulina OV, Johnson P, Tuneva JO, Chittur S, Carpenter DO Biochem Biophys Res Commun. 324(1):133-9. doi: 10.1016/j.bbrc.2004.09.019. November 5, 2004. View on PubMed.
DNA microarrays: tools for the 21st Century. Chittur SV Comb Chem High Throughput Screen. 7(6):531-7. September 2004. View on PubMed.
Multisubstrate analogue inhibitors of glucosamine-6-phosphate synthase from Candida albicans. Chittur S, Griffith R Bioorg Med Chem Lett. 12(18):2639-42. September 16, 2002. View on PubMed.
Crystal structure of imidazole glycerol phosphate synthase: a tunnel through a (beta/alpha)8 barrel joins two active sites. Chaudhuri BN, Lange SC, Myers RS, Chittur SV, Davisson VJ, Smith JL Structure. 9(10):987-97. October 2001. View on PubMed.
Mechanism for acivicin inactivation of triad glutamine amidotransferases. Chittur SV, Klem TJ, Shafer CM, Davisson VJ Biochemistry. 40(4):876-87. January 30, 2001. View on PubMed.
Expression and purification of imidazole glycerol phosphate synthase from Saccharomyces cerevisiae. Chittur SV, Chen Y, Davisson VJ Protein Expr Purif. 18(3):366-77. doi: 10.1006/prep.2000.1207. April 2000. View on PubMed.
N2-hydroxyguanosine 5'-monophosphate is a time-dependent inhibitor of Escherichia coli guanosine monophosphate synthetase. Deras ML, Chittur SV, Davisson VJ Biochemistry. 38(1):303-10. doi: 10.1021/bi981980r. January 5, 1999. View on PubMed.
Rapid and sensitive high-performance liquid chromatographic assay for 6-hydroxychlorzoxazone and chlorzoxazone in liver microsomes. Chittur SV, Tracy TS J Chromatogr B Biomed Sci Appl. 693(2):479-83. June 6, 1997. View on PubMed.
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