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Andriy Khobta

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Publication Info
Generation of reporter plasmids containing defined base modifications in the DNA strand of choice. Lühnsdorf B, Kitsera N, Warken D, Lingg T, Epe B, Khobta A Anal Biochem. :. doi: 10.1016/j.ab.2012.03.001. March 8, 2012. View on PubMed.
Interactions between DNA damage, repair, and transcription. Khobta A, Epe B Mutat Res. :. doi: 10.1016/j.mrfmmm.2011.07.014. August 12, 2011. View on PubMed.
8-Oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription, but is converted into transcription-blocking damage by OGG1. Kitsera N, Stathis D, Lühnsdorf B, Müller H, Carell T, Epe B, Khobta A Nucleic Acids Res. 39(14):5926-34. doi: 10.1093/nar/gkr163. March 25, 2011. View on PubMed.
Spontaneous mutagenesis in Csb(m/m)Ogg1⁻(/)⁻ mice is attenuated by dietary resveratrol. Fusser M, Nesse GJ, Khobta A, Xia N, Li H, Klungland A, Epe B Carcinogenesis. 32(1):80-5. doi: 10.1093/carcin/bgq196. November 9, 2010. View on PubMed.
Mouse CSB protein is important for gene expression in the presence of a single-strand break in the non-transcribed DNA strand. Khobta A, Lingg T, Schulz I, Warken D, Kitsera N, Epe B DNA Repair (Amst). 9(9):985-93. doi: 10.1016/j.dnarep.2010.06.011. September 4, 2010. View on PubMed.
Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter region. Khobta A, Anderhub S, Kitsera N, Epe B Nucleic Acids Res. 38(13):4285-95. doi: 10.1093/nar/gkq170. March 24, 2010. View on PubMed.
8-Oxoguanine DNA glycosylase (Ogg1) causes a transcriptional inactivation of damaged DNA in the absence of functional Cockayne syndrome B (Csb) protein. Khobta A, Kitsera N, Speckmann B, Epe B DNA Repair (Amst). 8(3):309-17. doi: 10.1016/j.dnarep.2008.11.006. March 1, 2009. View on PubMed.
Destabilized green fluorescent protein detects rapid removal of transcription blocks after genotoxic exposure. Kitsera N, Khobta A, Epe B Biotechniques. 43(2):222-7. August 2007. View on PubMed.
Generation and characterization of tTS-H4: a novel transcriptional repressor that is compatible with the reverse tetracycline-controlled TET-ON system. Bockamp E, Christel C, Hameyer D, Khobta A, Maringer M, Reis M, Heck R and 6 others J Gene Med. 9(4):308-18. doi: 10.1002/jgm.1012. April 2007. View on PubMed.
G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition in MLL-AF9 acute myeloid leukemia cells is p21 dependent and MLL-AF9 independent. Tonelli R, Sartini R, Fronza R, Freccero F, Franzoni M, Dongiovanni D, Ballarini M and 9 others Leukemia. 20(7):1307-10. doi: 10.1038/sj.leu.2404221. April 13, 2006. View on PubMed.
Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells. Khobta A, Ferri F, Lotito L, Montecucco A, Rossi R, Capranico G J Mol Biol. 357(1):127-38. doi: 10.1016/j.jmb.2005.12.069. March 17, 2006. View on PubMed.
Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster region of the human MLL gene. Khobta A, Carlo-Stella C, Capranico G Cancer Res. 64(8):2656-62. April 15, 2004. View on PubMed.
Enhanced CPT sensitivity of yeast cells and selective relaxation of Ga14 motif-containing DNA by novel Gal4-topoisomerase I fusion proteins. Alessandri M, Beretta GL, Ferretti E, Mancia A, Khobta A, Capranico G J Mol Biol. 337(2):295-305. doi: 10.1016/j.jmb.2004.01.032. March 19, 2004. View on PubMed.
Epidermoid carcinoma-derived antimicrobial peptide (ECAP) inhibits phosphorylation by protein kinases in vitro. Hobta A, Lisovskiy I, Mikhalap S, Kolybo D, Romanyuk S, Soldatkina M, Markeyeva N, Garmanchouk L, Sidorenko SP, Pogrebnoy PV Cell Biochem Funct. 19(4):291-8. doi: 10.1002/cbf.929. December 2001. View on PubMed.
A protein kinase inhibitor from A431 subline overexpressing TGF alpha possesses antimicrobial activity. Pogrebnoy PV, Hobta AI, Soldatkina MA, Garmanchouk LV, Markeeva NV, Eremenko T New Microbiol. 21(3):269-73. July 1998. View on PubMed.
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