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Ho Leung Ng

Assistant Professor of Chemistry - University of Hawaii at Manoa

Position - Company  
Sr. Scientist - ConfometRx

G-protein coupled receptors (GPCRs) are the largest protein family of drug targets.

Project responsibilities include recombinant expression, purification on the milligram scale, characterization, crystallization, and solving crystal structures of GPCRs. Established the crystallography lab at Confometrx. Part of team that crystallized and solved the novel structure of one GPCR.

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2009 - 2011
Associate Specialist - University of California, Berkeley

Protein crystallography, biochemistry, biophysics, computational biology.

Solved crystal structure of red fluorescent protein engineered for in vivo mammalian imaging, elucidating red shift mechanism, in collaboration with Nobel laureate Roger Tsien. Solved crystal structure and proposed solvent/ion transport mechanism for the iron storage protein ferritin. Supervised undergraduate and PhD students.

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2007 - 2009
Postdoctoral fellow - University of California, Berkeley

With Prof. Tom Alber. NIH Postdoctoral fellowship. Protein crystallography, biochemistry, biophysics, computational biology.

Solved crystal structures of 2 protein kinases and 2 phosphatases involved in tuberculosis pathology. Crystallized the 400 kD yeast septin cytoskeletal protein complex. Developed computational method for characterizing low occupancy protein conformations in x-ray crystallography electron density maps. Supervised undergraduate and PhD students.

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2001 - 2007
PhD student researcher - University of California, Los Angeles

MD/PhD student researcher with Profs. David Eisenberg and Richard Dickerson. NIH MSTP graduate fellowship.

Solved the crystal structure of DNA with DNA binding drugs. Solved the first crystal structure of DNA in an intermediate conformation between A- and B-DNA, published in PNAS. Codeveloped an algorithm for predicting protein-protein interactions based on homologous gene fusions, published in Science with 600+ citations.

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1994 - 2001
Assistant Professor of Chemistry - University of Hawaii at Manoa

Research program in protein crystallography and computational structural biology with a focus on cancer related proteins, protein complexes, membrane proteins, and structure based drug design. Current proteins of interest include protein kinases, kinase receptors, transcription factors, and GPCRs. Also working on developing methods for membrane protein production and crystallization.

Biophysical interests include crystallographic methods, and computational analysis of mechanisms of allostery and information transfer.

Teaching general chemistry, physical chemistry, and scientific ethics.

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2011 - Present
Degree - University  
PhD, Biochemistry - University of California, Los Angeles

With Profs. David Eisenberg and Richard Dickerson. Protein and nucleic acid crystallography, bioinformatics.

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1994 - 2001
BA, Biochemistry - Harvard University 1990 - 1994
High school - Iolani 1984 - 1990
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