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Nicholas Sherman

Director of Mass Spectrometry - University of Virginia Health System View Biosketch →

Position - Company  
Director - W.M. Keck Biomedical Mass Spectrometry Laboratory University of Virginia School of Medicine May 1995 - Present
Director of Mass Spectrometry - University of Virginia Health System

Oversee the Mass Spectrometry Core Facility at UVA working on biomedical and health problems.

Show details
May 1995 - Present
Degree - University  
Ph.D., Chemistry - University of Virginia 1990 - 1995
Bachelor of Science (B.S.), Chemistry - Bridgewater College 1986 - 1990
Publication Info
Integrated proteomics identified up-regulated focal adhesion-mediated proteins in human squamous cell carcinoma in an orthotopic murine model. Granato DC, Zanetti MR, Kawahara R, Yokoo S, Domingues RR, Aragão AZ, Agostini M and 10 others PLoS One. 9(5):e98208. doi: 10.1371/journal.pone.0098208. May 23, 2014. View on PubMed.
Dietary phytoestrogens inhibit experimental aneurysm formation in male mice. Lu G, Su G, Zhao Y, Johnston WF, Sherman NE, Rissman EF, Lau C, Ailawadi G, Upchurch GR Jr J Surg Res. 188(1):326-38. doi: 10.1016/j.jss.2013.11.1108. May 1, 2014. View on PubMed.
Proteomic analysis of cattle tick Rhipicephalus (Boophilus) microplus saliva: a comparison between partially and fully engorged females. Tirloni L, Reck J, Terra RM, Martins JR, Mulenga A, Sherman NE, Fox JW and 4 others PLoS One. 9(4):e94831. doi: 10.1371/journal.pone.0094831. April 24, 2014. View on PubMed.
Accurate label-free protein quantitation with high- and low-resolution mass spectrometers. Krey JF, Wilmarth PA, Shin JB, Klimek J, Sherman NE, Jeffery ED, Choi D, David LL, Barr-Gillespie PG J Proteome Res. 13(2):1034-44. doi: 10.1021/pr401017h. February 7, 2014. View on PubMed.
Phosphoproteome analysis reveals differences in phosphosite profiles between tumorigenic and non-tumorigenic epithelial cells. Winck FV, Belloni M, Pauletti BA, Zanella Jde L, Domingues RR, Sherman NE, Paes Leme AF J Proteomics. 96:67-81. doi: 10.1016/j.jprot.2013.10.039. January 16, 2014. View on PubMed.
Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase. Linford AS, Jiang NM, Edwards TE, Sherman NE, Van Voorhis WC, Stewart LJ, Myler PJ, Staker BL, Petri WA Jr Mol Biochem Parasitol. 193(1):33-44. doi: 10.1016/j.molbiopara.2014.01.003. January 2014. View on PubMed.
Molecular architecture of the chick vestibular hair bundle. Shin JB, Krey JF, Hassan A, Metlagel Z, Tauscher AN, Pagana JM, Sherman NE and 8 others Nat Neurosci. 16(3):365-74. doi: 10.1038/nn.3312. March 2013. View on PubMed.
Epidermal growth factor stimulates extracellular-signal regulated kinase phosphorylation of a novel site on cytoplasmic Dynein intermediate chain 2. Pullikuth AK, Ozdemir A, Cardenas D, Bailey E, Sherman NE, Pfister KK, Catling AD Int J Mol Sci. 14(2):3595-620. doi: 10.3390/ijms14023595. February 7, 2013. View on PubMed.
Identification of novel interaction between ADAM17 (a disintegrin and metalloprotease 17) and thioredoxin-1. Aragão AZ, Nogueira ML, Granato DC, Simabuco FM, Honorato RV, Hoffman Z, Yokoo S and 6 others J Biol Chem. 287(51):43071-82. doi: 10.1074/jbc.M112.364513. December 14, 2012. View on PubMed.
Matrix rigidity regulates cancer cell growth by modulating cellular metabolism and protein synthesis. Tilghman RW, Blais EM, Cowan CR, Sherman NE, Grigera PR, Jeffery ED, Fox JW and 4 others PLoS One. 7(5):e37231. doi: 10.1371/journal.pone.0037231. May 18, 2012. View on PubMed.
Proteomic analysis of the cyst stage of Entamoeba histolytica. Ali IK, Haque R, Siddique A, Kabir M, Sherman NE, Gray SA, Cangelosi GA, Petri WA Jr PLoS Negl Trop Dis. 6(5):e1643. doi: 10.1371/journal.pntd.0001643. May 8, 2012. View on PubMed.
Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells. Grigera PR, Ma L, Borgman CA, Pinto AF, Sherman NE, Parsons JT, Fox JW J Proteomics. 75(7):2153-9. doi: 10.1016/j.jprot.2012.01.012. April 3, 2012. View on PubMed.
Hemorrhagic activity of HF3, a snake venom metalloproteinase: insights from the proteomic analysis of mouse skin and blood plasma. Paes Leme AF, Sherman NE, Smalley DM, Sizukusa LO, Oliveira AK, Menezes MC, Fox JW, Serrano SM J Proteome Res. 11(1):279-91. doi: 10.1021/pr2006439. January 1, 2012. View on PubMed.
Phosphorylation sites in the cerebral cavernous malformations complex. Kim J, Sherman NE, Fox JW, Ginsberg MH J Cell Sci. 124(Pt 23):3929-32. doi: 10.1242/jcs.095471. December 1, 2011. View on PubMed.
Bothrops jararaca venom proteome rearrangement upon neonate to adult transition. Zelanis A, Tashima AK, Pinto AF, Paes Leme AF, Stuginski DR, Furtado MF, Sherman NE, Ho PL, Fox JW, Serrano SM Proteomics. 11(21):4218-28. doi: 10.1002/pmic.201100287. November 2011. View on PubMed.
ABRF-PRG07: advanced quantitative proteomics study. Falick AM, Lane WS, Lilley KS, MacCoss MJ, Phinney BS, Sherman NE, Weintraub ST, Witkowska HE, Yates NA J Biomol Tech. 22(1):21-6. April 2011. View on PubMed.
The ABRF Proteomics Research Group studies: educational exercises for qualitative and quantitative proteomic analyses. Friedman DB, Andacht TM, Bunger MK, Chien AS, Hawke DH, Krijgsveld J, Lane WS and 9 others Proteomics. 11(8):1371-81. doi: 10.1002/pmic.201000736. April 2011. View on PubMed.
Binding of β4γ5 by adenosine A1 and A2A receptors determined by stable isotope labeling with amino acids in cell culture and mass spectrometry. Bigler Wang D, Sherman NE, Shannon JD, Leonhardt SA, Mayeenuddin LH, Yeager M, McIntire WE Biochemistry. 50(2):207-20. doi: 10.1021/bi101227y. January 18, 2011. View on PubMed.
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient. Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB Front Microbiol. 2:162. doi: 10.3389/fmicb.2011.00162. 2011. View on PubMed.
Isolation and partial sequence of a Kunitz-type elastase specific inhibitor from marama bean (Tylosema esculentum). Nadaraja D, Weintraub ST, Hakala KW, Sherman NE, Starcher B J Enzyme Inhib Med Chem. 25(3):377-82. doi: 10.3109/14756360903179500. June 2010. View on PubMed.
Antibacterial activity of six novel peptides from Tityus discrepans scorpion venom. A fluorescent probe study of microbial membrane Na+ permeability changes. Díaz P, D'Suze G, Salazar V, Sevcik C, Shannon JD, Sherman NE, Fox JW Toxicon. 54(6):802-17. doi: 10.1016/j.toxicon.2009.06.014. November 2009. View on PubMed.
Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Tao J, Hu K, Chang Q, Wu H, Sherman NE, Martinowich K, Klose RJ and 4 others Proc Natl Acad Sci U S A. 106(12):4882-7. doi: 10.1073/pnas.0811648106. March 24, 2009. View on PubMed.
Multi-peptide vaccines vialed as peptide mixtures can be stable reagents for use in peptide-based immune therapies. Chianese-Bullock KA, Lewis ST, Sherman NE, Shannon JD, Slingluff CL Jr Vaccine. 27(11):1764-70. doi: 10.1016/j.vaccine.2009.01.018. March 10, 2009. View on PubMed.
Entamoeba histolytica phagocytosis of human erythrocytes involves PATMK, a member of the transmembrane kinase family. Boettner DR, Huston CD, Linford AS, Buss SN, Houpt E, Sherman NE, Petri WA Jr PLoS Pathog. 4(1):e8. doi: 10.1371/journal.ppat.0040008. January 2008. View on PubMed.
Identification of phosphorylation sites in betaPIX and PAK1. Mayhew MW, Jeffery ED, Sherman NE, Nelson K, Polefrone JM, Pratt SJ, Shabanowitz J and 4 others J Cell Sci. 120(Pt 22):3911-8. doi: 10.1242/jcs.008177. November 15, 2007. View on PubMed.
An experimentally derived database of candidate Ras-interacting proteins. Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Han J, Haling JR, Sherman NE, Fox JW, Hunt DF, Ginsberg MH J Proteome Res. 6(5):1806-11. doi: 10.1021/pr060630l. May 2007. View on PubMed.
Autocatalytic phosphorylation of CDK2 at the activating Thr160. Abbas T, Jha S, Sherman NE, Dutta A Cell Cycle. 6(7):843-52. doi: 10.4161/cc.6.7.4000. April 1, 2007. View on PubMed.
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Dorrello NV, Peschiaroli A, Guardavaccaro D, Colburn NH, Sherman NE, Pagano M Science. 314(5798):467-71. doi: 10.1126/science.1130276. October 20, 2006. View on PubMed.
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Peschiaroli A, Dorrello NV, Guardavaccaro D, Venere M, Halazonetis T, Sherman NE, Pagano M Mol Cell. 23(3):319-29. doi: 10.1016/j.molcel.2006.06.013. August 4, 2006. View on PubMed.
Comparison of indirect and direct approaches using ion-trap and Fourier transform ion cyclotron resonance mass spectrometry for exploring viperid venom proteomes. Fox JW, Ma L, Nelson K, Sherman NE, Serrano SM Toxicon. 47(6):700-14. doi: 10.1016/j.toxicon.2006.01.022. May 2006. View on PubMed.
Purification and characterization of an esterase isozyme involved in hydrolysis of organophosphorus compounds from an insecticide resistant pest, Helicoverpa armigera (Lepidoptera: Noctüidae). Srinivas R, Jayalakshmi SK, Sreeramulu K, Sherman NE, Rao J Biochim Biophys Acta. 1760(3):310-7. doi: 10.1016/j.bbagen.2005.12.009. March 2006. View on PubMed.
ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. Wright PW, Bolling LC, Calvert ME, Sarmento OF, Berkeley EV, Shea MC, Hao Z and 11 others Dev Biol. 256(1):73-88. April 1, 2003. View on PubMed.
The neurotoxic phospholipase A2 associates, through a non-phosphorylated binding motif, with 14-3-3 protein gamma and epsilon isoforms. Sribar J, Sherman NE, Prijatelj P, Faure G, Gubensek F, Fox JW, Aitken A, Pungercar J, Krizaj I Biochem Biophys Res Commun. 302(4):691-6. March 21, 2003. View on PubMed.
Cloning and characterization of a novel sperm-associated isoantigen (E-3) with defensin- and lectin-like motifs expressed in rat epididymis. Rao J, Herr JC, Reddi PP, Wolkowicz MJ, Bush LA, Sherman NE, Black M, Flickinger CJ Biol Reprod. 68(1):290-301. January 2003. View on PubMed.
A novel asparaginase-like protein is a sperm autoantigen in rats. Bush LA, Herr JC, Wolkowicz M, Sherman NE, Shore A, Flickinger CJ Mol Reprod Dev. 62(2):233-47. doi: 10.1002/mrd.10092. June 2002. View on PubMed.
High-molecular-mass receptors for ammodytoxin in pig are tissue-specific isoforms of M-type phospholipase A(2) receptor. Vardjan N, Sherman NE, Pungercar J, Fox JW, Gubensek F, Krizaj I Biochem Biophys Res Commun. 289(1):143-9. doi: 10.1006/bbrc.2001.5940. November 23, 2001. View on PubMed.
Co-localization of the inositol 1,4,5-trisphosphate receptor and calreticulin in the equatorial segment and in membrane bounded vesicles in the cytoplasmic droplet of human spermatozoa. Naaby-Hansen S, Wolkowicz MJ, Klotz K, Bush LA, Westbrook VA, Shibahara H, Shetty J and 8 others Mol Hum Reprod. 7(10):923-33. October 2001. View on PubMed.
Differential extraction and enrichment of human sperm surface proteins in a proteome: identification of immunocontraceptive candidates. Shetty J, Diekman AB, Jayes FC, Sherman NE, Naaby-Hansen S, Flickinger CJ, Herr JC Electrophoresis. 22(14):3053-66. doi: 10.1002/1522-2683(200108)22:14<3053::AID-ELPS3053>3.0.CO;2-K. August 2001. View on PubMed.
Proteolytic processing of the human T-cell lymphotropic virus 1 reverse transcriptase: identification of the N-terminal cleavage site by mass spectrometry. Agbuya PG, Sherman NE, Moen LK Arch Biochem Biophys. 392(1):93-102. doi: 10.1006/abbi.2001.2432. August 1, 2001. View on PubMed.
Outer dense fiber proteins are dominant postobstruction autoantigens in adult Lewis rats. Flickinger CJ, Rao J, Bush LA, Sherman NE, Oko RJ, Jayes FC, Herr JC Biol Reprod. 64(5):1451-9. May 2001. View on PubMed.
A high affinity acceptor for phospholipase A2 with neurotoxic activity is a calmodulin. Sribar J, Copic A, Paris A, Sherman NE, Gubensek F, Fox JW, Krizaj I J Biol Chem. 276(16):12493-6. doi: 10.1074/jbc.C100048200. April 20, 2001. View on PubMed.
Fingerprinting Trichoderma reesei hydrolases in a commercial cellulase preparation. Vinzant TB, Adney WS, Decker SR, Baker JO, Kinter MT, Sherman NE, Fox JW, Himmel ME Appl Biochem Biotechnol. 91-93:99-107. 2001. View on PubMed.
Pseudomonas aeruginosa and a proteomic approach to bacterial pathogenesis. Sherman NE, Stefansson B, Fox JW, Goldberg JB Dis Markers. 17(4):285-93. 2001. View on PubMed.
Tracking lysozyme unfolding during salt-induced precipitation with hydrogen exchange and mass spectrometry. Tobler SA, Sherman NE, Fernandez EJ Biotechnol Bioeng. 71(3):194-207. 2001. View on PubMed.
Comparison of proteins expressed by Pseudomonas aeruginosa strains representing initial and chronic isolates from a cystic fibrosis patient: an analysis by 2-D gel electrophoresis and capillary column liquid chromatography-tandem mass spectrometry. Hanna SL, Sherman NE, Kinter MT, Goldberg JB Microbiology. 146 ( Pt 10):2495-508. doi: 10.1099/00221287-146-10-2495. October 2000. View on PubMed.
T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity. Sandberg JK, Franksson L, Sundbäck J, Michaelsson J, Petersson M, Achour A, Wallin RP and 6 others J Immunol. 165(1):25-33. July 1, 2000. View on PubMed.
Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA. Mehta A, Kinter MT, Sherman NE, Driscoll DM Mol Cell Biol. 20(5):1846-54. March 2000. View on PubMed.
Arginine to glutamine substitutions in the fourth module of Xenopus interphotoreceptor retinoid-binding protein. Baer CA, Van Niel EE, Cronk JW, Kinter MT, Sherman NE, Braiman MS, Gonzalez-Fernandez F Mol Vis. 4:30. December 30, 1998. View on PubMed.
G protein gamma subunits with altered prenylation sequences are properly modified when expressed in Sf9 cells. Lindorfer MA, Sherman NE, Woodfork KA, Fletcher JE, Hunt DF, Garrison JC J Biol Chem. 271(31):18582-7. August 2, 1996. View on PubMed.
A Listeria monocytogenes pentapeptide is presented to cytolytic T lymphocytes by the H2-M3 MHC class Ib molecule. Gulden PH, Fischer P 3rd, Sherman NE, Wang W, Engelhard VH, Shabanowitz J, Hunt DF, Pamer EG Immunity. 5(1):73-9. July 1996. View on PubMed.
Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein. Wang W, Meadows LR, den Haan JM, Sherman NE, Chen Y, Blokland E, Shabanowitz J, Agulnik AI, Hendrickson RC, Bishop CE Science. 269(5230):1588-90. September 15, 1995. View on PubMed.
Identification of a graft versus host disease-associated human minor histocompatibility antigen. den Haan JM, Sherman NE, Blokland E, Huczko E, Koning F, Drijfhout JW, Skipper J, Shabanowitz J, Hunt DF, Engelhard VH Science. 268(5216):1476-80. June 9, 1995. View on PubMed.
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