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Towia Libermann

Associate Professor of Medicine - Genomics, Proteomics, Bioinformatics and Systems Biology Center
Boston Massachusetts, US
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Position - Company  
Associate Professor of Medicine - Genomics, Proteomics, Bioinformatics and Systems Biology Center Beth Israel Deaconess Medical Center 2011 - Present
Degree - University  
Postdoc, Immunology, Molecular Biology - Whitehead Institute 1987 - 1990
PhD, Chemical Immunology - The Weizmann Institute of Science 1981 - 1986
Publication Info
Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells. Oliveira AP, Simabuco FM, Tamura RE, Guerrero MC, Ribeiro PG, Libermann TA, Zerbini LF, Ventura AM Virus Res. 177(1):108-12. doi: 10.1016/j.virusres.2013.07.010. October 2013. View on PubMed.
Pressure-overload hypertrophy of the developing heart reveals activation of divergent gene and protein pathways in the left and right ventricular myocardium. Friehs I, Cowan DB, Choi YH, Black KM, Barnett R, Bhasin MK, Daly C and 6 others Am J Physiol Heart Circ Physiol. 304(5):H697-708. doi: 10.1152/ajpheart.00802.2012. March 1, 2013. View on PubMed.
Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. Bhasin MK, Dusek JA, Chang BH, Joseph MG, Denninger JW, Fricchione GL, Benson H, Libermann TA PLoS One. 8(5):e62817. doi: 10.1371/journal.pone.0062817. 2013. View on PubMed.
Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. Junker Y, Zeissig S, Kim SJ, Barisani D, Wieser H, Leffler DA, Zevallos V and 5 others J Exp Med. 209(13):2395-408. doi: 10.1084/jem.20102660. December 17, 2012. View on PubMed.
Microarray and proteomic analysis of the cardioprotective effects of cold blood cardioplegia in the mature and aged male and female. Black KM, Barnett RJ, Bhasin MK, Daly C, Dillon ST, Libermann TA, Levitsky S, McCully JD Physiol Genomics. 44(21):1027-41. doi: 10.1152/physiolgenomics.00011.2012. November 1, 2012. View on PubMed.
Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival. Koulmanda M, Bhasin M, Fan Z, Hanidziar D, Goel N, Putheti P, Movahedi B, Libermann TA, Strom TB Proc Natl Acad Sci U S A. 109(38):15443-8. doi: 10.1073/pnas.1018366109. September 18, 2012. View on PubMed.
A metabolic prosurvival role for PML in breast cancer. Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC and 13 others J Clin Invest. 122(9):3088-100. doi: 10.1172/JCI62129. September 4, 2012. View on PubMed.
Creating a "pro-survival" phenotype through epigenetic modulation. Li Y, Liu B, Gu X, Kochanek AR, Fukudome EY, Liu Z, Zhao T and 5 others Surgery. 152(3):455-64. doi: 10.1016/j.surg.2012.06.036. September 2012. View on PubMed.
NSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo. Duncan K, Uwimpuhwe H, Czibere A, Sarkar D, Libermann TA, Fisher PB, Zerbini LF IUBMB Life. :. doi: 10.1002/iub.1035. May 11, 2012. View on PubMed.
The Role of TNF-α in Mice with Type 1- and 2- Diabetes. Koulmanda M, Bhasin M, Awdeh Z, Qipo A, Fan Z, Hanidziar D, Putheti P and 4 others PLoS One. 7(5):e33254. doi: 10.1371/journal.pone.0033254. May 11, 2012. View on PubMed.
GADD45 proteins: central players in tumorigenesis. Tamura RE, de Vasconcellos JF, Sarkar D, Libermann TA, Fisher PB, Zerbini LF Curr Mol Med. :. April 18, 2012. View on PubMed.
The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target. Paccez JD, Vasques GJ, Correa RG, Vasconcellos JF, Duncan K, Gu X, Bhasin M, Libermann TA, Zerbini LF Oncogene. :. doi: 10.1038/onc.2012.89. March 12, 2012. View on PubMed.
Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy. Zerbini LF, Tamura RE, Correa RG, Czibere A, Cordeiro J, Bhasin M, Simabuco FM and 7 others PLoS One. 6(9):e24285. doi: 10.1371/journal.pone.0024285. September 12, 2011. View on PubMed.
JunD-mediated repression of GADD45alpha and gamma regulates escape from cell death in prostate cancer. Zerbini LF, de Vasconcellos JF, Czibere A, Wang Y, Paccez JD, Gu X, Zhou JR, Libermann TA Cell Cycle. 10(15):. doi: 10.4161/cc.10.15.16057. August 1, 2011. View on PubMed.
Resistance of renal cell carcinoma to sorafenib is mediated by potentially reversible gene expression. Zhang L, Bhasin M, Schor-Bardach R, Wang X, Collins MP, Panka D, Putheti P and 7 others PLoS One. 6(4):e19144. doi: 10.1371/journal.pone.0019144. April 29, 2011. View on PubMed.
PTH regulates Myleoid ELF-1-like factor (MEF)-induced MAB-21-like-1 (MAB21L1) expression through the JNK1 pathway. Kim BK, Park YJ, Libermann TA, Cho JY J Cell Biochem. :. doi: 10.1002/jcb.23124. April 4, 2011. View on PubMed.
A20 modulates lipid metabolism and energy production to promote liver regeneration. Damrauer SM, Studer P, da Silva CG, Longo CR, Ramsey HE, Csizmadia E, Shrikhande GV and 4 others PLoS One. 6(3):e17715. doi: 10.1371/journal.pone.0017715. March 17, 2011. View on PubMed.
Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum. Horst D, Gu X, Bhasin M, Yang Q, Verzi M, Lin D, Joseph M and 5 others J Biol Chem. 285(45):35047-55. doi: 10.1074/jbc.M110.164541. November 5, 2010. View on PubMed.
Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells. Kornek M, Popov Y, Libermann TA, Afdhal NH, Schuppan D Hepatology. 53(1):230-42. doi: 10.1002/hep.23999. October 26, 2010. View on PubMed.
Nna1 mediates Purkinje cell dendritic development via lysyl oxidase propeptide and NF-κB signaling. Li J, Gu X, Ma Y, Calicchio ML, Kong D, Teng YD, Yu L and 7 others Neuron. 68(1):45-60. doi: 10.1016/j.neuron.2010.08.013. October 6, 2010. View on PubMed.
Alterations of the gene expression profile in renal cell carcinoma after treatment with the histone deacetylase-inhibitor valproic acid and interferon-alpha. Juengel E, Bhasin M, Libermann T, Barth S, Michaelis M, Cinatl J Jr, Jones J, Hudak L, Jonas D, Blaheta RA World J Urol. :. doi: 10.1007/s00345-010-0582-y. July 17, 2010. View on PubMed.
Optimizing a proteomics platform for urine biomarker discovery. Afkarian M, Bhasin M, Dillon ST, Guerrero MC, Nelson RG, Knowler WC, Thadhani R, Libermann TA Mol Cell Proteomics. 9(10):2195-204. doi: 10.1074/mcp.M110.000992. May 28, 2010. View on PubMed.
Bioinformatic identification and characterization of human endothelial cell-restricted genes. Bhasin M, Yuan L, Keskin DB, Otu HH, Libermann TA, Oettgen P BMC Genomics. 11:342. doi: 10.1186/1471-2164-11-342. May 28, 2010. View on PubMed.
Analysis of multiple sarcoma expression datasets: implications for classification, oncogenic pathway activation and chemotherapy resistance. Konstantinopoulos PA, Fountzilas E, Goldsmith JD, Bhasin M, Pillay K, Francoeur N, Libermann TA, Gebhardt MC, Spentzos D PLoS One. 5(4):e9747. doi: 10.1371/journal.pone.0009747. April 1, 2010. View on PubMed.
GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes. Tsuchimochi K, Otero M, Dragomir CL, Plumb DA, Zerbini LF, Libermann TA, Marcu KB, Komiya S, Ijiri K, Goldring MB J Biol Chem. 285(11):8395-407. doi: 10.1074/jbc.M109.038638. March 12, 2010. View on PubMed.
The synergistic regulatory effect of Runx2 and MEF transcription factors on osteoblast differentiation markers. Lee JM, Libermann TA, Cho JY J Periodontal Implant Sci. 40(1):39-44. doi: 10.5051/jpis.2010.40.1.39. February 28, 2010. View on PubMed.
Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer. Arredouani MS, Lu B, Bhasin M, Eljanne M, Yue W, Mosquera JM, Bubley GJ and 4 others Clin Cancer Res. 15(18):5794-802. doi: 10.1158/1078-0432.CCR-09-0911. September 15, 2009. View on PubMed.
Identification of a novel potential biomarker in a model of hemorrhagic shock and valproic acid treatment. Li Y, Liu B, Dillon ST, Fukudome EY, Kheirbek T, Sailhamer EA, Velmahos G, deMoya M, Libermann TA, Alam HB J Surg Res. 159(1):474-81. doi: 10.1016/j.jss.2009.04.011. May 13, 2009. View on PubMed.
Proteomic analysis of a PDEF Ets transcription factor-interacting protein complex. Cho JY, Lee M, Ahn JM, Park ES, Cho JH, Lee SJ, Kim BG and 5 others J Proteome Res. 8(3):1327-37. doi: 10.1021/pr800683b. March 2009. View on PubMed.
Differential gene expression of bone marrow-derived CD34+ cells is associated with survival of patients suffering from myelodysplastic syndrome. Prall WC, Czibere A, Grall F, Spentzos D, Steidl U, Giagounidis AA, Kuendgen A and 7 others Int J Hematol. 89(2):173-87. doi: 10.1007/s12185-008-0242-9. January 20, 2009. View on PubMed.
Carboplatin-induced gene expression changes in vitro are prognostic of survival in epithelial ovarian cancer. Konstantinopoulos PA, Fountzilas E, Pillay K, Zerbini LF, Libermann TA, Cannistra SA, Spentzos D BMC Med Genomics. 1:59. doi: 10.1186/1755-8794-1-59. November 28, 2008. View on PubMed.
Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S and 6 others Proc Natl Acad Sci U S A. 105(42):16242-7. doi: 10.1073/pnas.0808031105. October 21, 2008. View on PubMed.
Gene expression profile of mouse prostate tumors reveals dysregulations in major biological processes and identifies potential murine targets for preclinical development of human prostate cancer therapy. Haram KM, Peltier HJ, Lu B, Bhasin M, Otu HH, Choy B, Regan M and 4 others Prostate. 68(14):1517-30. doi: 10.1002/pros.20803. October 1, 2008. View on PubMed.
Genomic counter-stress changes induced by the relaxation response. Dusek JA, Otu HH, Wohlhueter AL, Bhasin M, Zerbini LF, Joseph MG, Benson H, Libermann TA PLoS One. 3(7):e2576. doi: 10.1371/journal.pone.0002576. July 2, 2008. View on PubMed.
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Ijiri K, Zerbini LF, Peng H, Otu HH, Tsuchimochi K, Otero M, Dragomir C and 8 others Arthritis Rheum. 58(7):2075-87. doi: 10.1002/art.23504. July 2008. View on PubMed.
Tissue-based research in kidney cancer: current challenges and future directions. Signoretti S, Bratslavsky G, Waldman FM, Reuter VE, Haaga J, Merino M, Thomas GV and 8 others Clin Cancer Res. 14(12):3699-705. doi: 10.1158/1078-0432.CCR-07-4733. June 15, 2008. View on PubMed.
Gene expression analysis of embryonic stem cells expressing VE-cadherin (CD144) during endothelial differentiation. Nikolova-Krstevski V, Bhasin M, Otu HH, Libermann T, Oettgen P BMC Genomics. 9:240. doi: 10.1186/1471-2164-9-240. May 22, 2008. View on PubMed.
ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes. Peng H, Tan L, Osaki M, Zhan Y, Ijiri K, Tsuchimochi K, Otero M and 7 others J Cell Physiol. 215(2):562-73. doi: 10.1002/jcp.21338. May 2008. View on PubMed.
E-NTPDases and ecto-5'-nucleotidase expression profile in rat heart left ventricle and the extracellular nucleotide hydrolysis by their nerve terminal endings. Rücker B, Almeida ME, Libermann TA, Zerbini LF, Wink MR, Sarkis JJ Life Sci. 82(9-10):477-86. doi: 10.1016/j.lfs.2007.12.003. February 27, 2008. View on PubMed.
Serum proteomics and biomarkers in hepatocellular carcinoma and chronic liver disease. Zinkin NT, Grall F, Bhaskar K, Otu HH, Spentzos D, Kalmowitz B, Wells M and 4 others Clin Cancer Res. 14(2):470-7. doi: 10.1158/1078-0432.CCR-07-0586. January 15, 2008. View on PubMed.
Proteomic identification of interleukin-2 therapy response in metastatic renal cell cancer. Jones J, Otu HH, Grall F, Spentzos D, Can H, Aivado M, Belldegrun AS, Pantuck AJ, Libermann TA J Urol. 179(2):730-6. doi: 10.1016/j.juro.2007.09.016. December 20, 2007. View on PubMed.
Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. Marselli L, Thorne J, Ahn YB, Omer A, Sgroi DC, Libermann T, Otu HH, Sharma A, Bonner-Weir S, Weir GC J Clin Endocrinol Metab. 93(3):1046-53. doi: 10.1210/jc.2007-0931. December 11, 2007. View on PubMed.
c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells. Zhang X, Zhang L, Yang H, Huang X, Otu H, Libermann TA, DeWolf WC, Khosravi-Far R, Olumi AF Cancer Res. 67(19):9425-34. doi: 10.1158/0008-5472.CAN-07-1310. October 1, 2007. View on PubMed.
Genomic expression pathways associated with brain injury after cardiopulmonary bypass. Ramlawi B, Otu H, Rudolph JL, Mieno S, Kohane IS, Can H, Libermann TA, Marcantonio ER, Bianchi C, Sellke FW J Thorac Cardiovasc Surg. 134(4):996-1005. doi: 10.1016/j.jtcvs.2007.01.096. October 2007. View on PubMed.
Biochemical characterization of ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP, E.C. from rat heart left ventricle. Rücker B, Almeida ME, Libermann TA, Zerbini LF, Wink MR, Sarkis JJ Mol Cell Biochem. 306(1-2):247-54. doi: 10.1007/s11010-007-9576-5. September 5, 2007. View on PubMed.
IGF axis gene expression patterns are prognostic of survival in epithelial ovarian cancer. Spentzos D, Cannistra SA, Grall F, Levine DA, Pillay K, Libermann TA, Mantzoros CS Endocr Relat Cancer. 14(3):781-90. doi: 10.1677/ERC-06-0073. September 2007. View on PubMed.
Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells. Prall WC, Czibere A, Jäger M, Spentzos D, Libermann TA, Gattermann N, Haas R, Aivado M Mech Ageing Dev. 128(9):503-10. doi: 10.1016/j.mad.2007.06.008. July 4, 2007. View on PubMed.
Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor. Huh K, Zhou X, Hayakawa H, Cho JY, Libermann TA, Jin J, Harper JW, Munger K J Virol. 81(18):9737-47. doi: 10.1128/JVI.00881-07. July 3, 2007. View on PubMed.
NTPDase and 5' ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor. Buffon A, Wink MR, Ribeiro BV, Casali EA, Libermann TA, Zerbini LF, Robson SC, Sarkis JJ Biochim Biophys Acta. 1770(8):1259-65. doi: 10.1016/j.bbagen.2007.05.004. May 21, 2007. View on PubMed.
Reduced PDEF expression increases invasion and expression of mesenchymal genes in prostate cancer cells. Gu X, Zerbini LF, Otu HH, Bhasin M, Yang Q, Joseph MG, Grall F, Onatunde T, Correa RG, Libermann TA Cancer Res. 67(9):4219-26. doi: 10.1158/0008-5472.CAN-06-3689. May 1, 2007. View on PubMed.
Restoration of liver mass after injury requires proliferative and not embryonic transcriptional patterns. Otu HH, Naxerova K, Ho K, Can H, Nesbitt N, Libermann TA, Karp SJ J Biol Chem. 282(15):11197-204. doi: 10.1074/jbc.M608441200. April 13, 2007. View on PubMed.
Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy. Otu HH, Can H, Spentzos D, Nelson RG, Hanson RL, Looker HC, Knowler WC and 4 others Diabetes Care. 30(3):638-43. doi: 10.2337/dc06-1656. March 2007. View on PubMed.
A high-fat, ketogenic diet induces a unique metabolic state in mice. Kennedy AR, Pissios P, Otu H, Roberson R, Xue B, Asakura K, Furukawa N and 5 others Am J Physiol Endocrinol Metab. 292(6):E1724-39. doi: 10.1152/ajpendo.00717.2006. February 13, 2007. View on PubMed.
Serum proteome profiling detects myelodysplastic syndromes and identifies CXC chemokine ligands 4 and 7 as markers for advanced disease. Aivado M, Spentzos D, Germing U, Alterovitz G, Meng XY, Grall F, Giagounidis AA and 13 others Proc Natl Acad Sci U S A. 104(4):1307-12. doi: 10.1073/pnas.0610330104. January 23, 2007. View on PubMed.
Genomics of renal cell cancer: the biology behind and the therapy ahead. Jones J, Libermann TA Clin Cancer Res. 13(2 Pt 2):685s-692s. doi: 10.1158/1078-0432.CCR-06-1867. January 15, 2007. View on PubMed.
Innovations and challenges in renal cell carcinoma: summary statement from the Second Cambridge Conference. Atkins MB, Ernstoff MS, Figlin RA, Flaherty KT, George DJ, Kaelin WG Jr, Kwon ED and 12 others Clin Cancer Res. 13(2 Pt 2):667s-670s. doi: 10.1158/1078-0432.CCR-06-2231. January 15, 2007. View on PubMed.
Gene expression during chemically induced liver fibrosis: effect of halofuginone on TGF-beta signaling. Gnainsky Y, Kushnirsky Z, Bilu G, Hagai Y, Genina O, Volpin H, Bruck R and 7 others Cell Tissue Res. 328(1):153-66. doi: 10.1007/s00441-006-0330-1. December 19, 2006. View on PubMed.
A novel pathway involving melanoma differentiation associated gene-7/interleukin-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells. Zerbini LF, Czibere A, Wang Y, Correa RG, Otu H, Joseph M, Takayasu Y and 8 others Cancer Res. 66(24):11922-31. doi: 10.1158/0008-5472.CAN-06-2068. December 15, 2006. View on PubMed.
Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells. Steidl U, Rosenbauer F, Verhaak RG, Gu X, Ebralidze A, Otu HH, Klippel S and 11 others Nat Genet. 38(11):1269-77. doi: 10.1038/ng1898. October 15, 2006. View on PubMed.
Exisulind induces apoptosis in advanced myelodysplastic syndrome (MDS) and acute myeloid leukaemia/MDS. Czibere A, Prall WC, Zerbini LF, Jäger M, Kobbe G, Knipp S, Libermann TA, Haas R, Aivado M Br J Haematol. 135(3):355-7. doi: 10.1111/j.1365-2141.2006.06298.x. September 15, 2006. View on PubMed.
Proteomic analysis of the allograft response. El Essawy B, Otu HH, Choy B, Zheng XX, Libermann TA, Strom TB Transplantation. 82(2):267-74. doi: 10.1097/01.tp.0000226254.89987.ec. July 27, 2006. View on PubMed.
Urine proteomic profiling of pediatric nephrotic syndrome. Khurana M, Traum AZ, Aivado M, Wells MP, Guerrero M, Grall F, Libermann TA, Schachter AD Pediatr Nephrol. 21(9):1257-65. doi: 10.1007/s00467-006-0165-8. June 30, 2006. View on PubMed.
Soluble endoglin contributes to the pathogenesis of preeclampsia. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y and 12 others Nat Med. 12(6):642-9. doi: 10.1038/nm1429. June 4, 2006. View on PubMed.
SELDI-TOF MS of quadruplicate urine and serum samples to evaluate changes related to storage conditions. Traum AZ, Wells MP, Aivado M, Libermann TA, Ramoni MF, Schachter AD Proteomics. 6(5):1676-80. doi: 10.1002/pmic.200500174. March 2006. View on PubMed.
Targeting transcription factors for cancer gene therapy. Libermann TA, Zerbini LF Curr Gene Ther. 6(1):17-33. February 2006. View on PubMed.
Antimyeloma activity of heat shock protein-90 inhibition. Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Kung AL, Davies FE, Morgan G and 12 others Blood. 107(3):1092-100. doi: 10.1182/blood-2005-03-1158. February 1, 2006. View on PubMed.
Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes. Wink MR, Braganhol E, Tamajusuku AS, Lenz G, Zerbini LF, Libermann TA, Sévigny J, Battastini AM, Robson SC Neuroscience. 138(2):421-32. doi: 10.1016/j.neuroscience.2005.11.039. January 18, 2006. View on PubMed.
Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells. Ramnarain DB, Park S, Lee DY, Hatanpaa KJ, Scoggin SO, Otu H, Libermann TA and 6 others Cancer Res. 66(2):867-74. doi: 10.1158/0008-5472.CAN-05-2753. January 15, 2006. View on PubMed.
A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y and 13 others J Biol Chem. 280(46):38544-55. doi: 10.1074/jbc.M504202200. November 18, 2005. View on PubMed.
Unique gene expression profile based on pathologic response in epithelial ovarian cancer. Spentzos D, Levine DA, Kolia S, Otu H, Boyd J, Libermann TA, Cannistra SA J Clin Oncol. 23(31):7911-8. doi: 10.1200/JCO.2005.02.9363. November 1, 2005. View on PubMed.
Blockage of NF-kappaB induces serine 15 phosphorylation of mutant p53 by JNK kinase in prostate cancer cells. Zerbini LF, Wang Y, Correa RG, Cho JY, Libermann TA Cell Cycle. 4(9):1247-53. doi: 10.4161/cc.4.9.1966. September 24, 2005. View on PubMed.
Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell. Wada Y, Otu H, Wu S, Abid MR, Okada H, Libermann T, Kodama T, Shih SC, Minami T, Aird WC FASEB J. 19(13):1914-6. doi: 10.1096/fj.05-4037fje. September 19, 2005. View on PubMed.
GADD45 deregulation in cancer: frequently methylated tumor suppressors and potential therapeutic targets. Zerbini LF, Libermann TA Clin Cancer Res. 11(18):6409-13. doi: 10.1158/1078-0432.CCR-05-1475. September 15, 2005. View on PubMed.
Gene signatures of progression and metastasis in renal cell cancer. Jones J, Otu H, Spentzos D, Kolia S, Inan M, Beecken WD, Fellbaum C and 5 others Clin Cancer Res. 11(16):5730-9. doi: 10.1158/1078-0432.CCR-04-2225. August 15, 2005. View on PubMed.
The nonsteroidal anti-inflammatory drug Exisulind selectively induces apoptosis via JNK in secondary acute myeloid leukemia after myelodysplastic syndrome. Czibere A, Prall WC, Zerbini LF, Grall F, Craigie EC, Ulrich SD, Giagounidis AA, Haas R, Libermann TA, Aivado M Cell Cycle. 4(6):812-7. doi: 10.4161/cc.4.6.1722. June 8, 2005. View on PubMed.
A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions. Mazzocca A, Coppari R, De Franco R, Cho JY, Libermann TA, Pinzani M, Toker A Cancer Res. 65(11):4728-38. doi: 10.1158/0008-5472.CAN-04-4449. June 1, 2005. View on PubMed.
The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes. Grall FT, Prall WC, Wei W, Gu X, Cho JY, Choy BK, Zerbini LF and 6 others FEBS J. 272(7):1676-87. doi: 10.1111/j.1742-4658.2005.04592.x. April 2005. View on PubMed.
Life and death in cancer. GADD45 alpha and gamma are critical regulators of NF-kappaB mediated escape from programmed cell death. Zerbini LF, Libermann TA Cell Cycle. 4(1):18-20. doi: 10.4161/cc.4.1.1363. January 11, 2005. View on PubMed.
Optimization and evaluation of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) with reversed-phase protein arrays for protein profiling. Aivado M, Spentzos D, Alterovitz G, Otu HH, Grall F, Giagounidis AA, Wells M and 7 others Clin Chem Lab Med. 43(2):133-40. doi: 10.1515/CCLM.2005.022. 2005. View on PubMed.
Gene expression signature with independent prognostic significance in epithelial ovarian cancer. Spentzos D, Levine DA, Ramoni MF, Joseph M, Gu X, Boyd J, Libermann TA, Cannistra SA J Clin Oncol. 22(23):4700-10. doi: 10.1200/JCO.2004.04.070. December 1, 2004. View on PubMed.
Differential transcriptional effects of PTH and estrogen during anabolic bone formation. von Stechow D, Zurakowski D, Pettit AR, Müller R, Gronowicz G, Chorev M, Otu H, Libermann T, Alexander JM J Cell Biochem. 93(3):476-90. doi: 10.1002/jcb.20174. October 15, 2004. View on PubMed.
Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest. Voisine P, Ruel M, Khan TA, Bianchi C, Xu SH, Kohane I, Libermann TA, Otu H, Saltiel AR, Sellke FW Circulation. 110(11 Suppl 1):II280-6. doi: 10.1161/01.CIR.0000138974.18839.02. September 14, 2004. View on PubMed.
NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Zerbini LF, Wang Y, Czibere A, Correa RG, Cho JY, Ijiri K, Wei W and 6 others Proc Natl Acad Sci U S A. 101(37):13618-23. doi: 10.1073/pnas.0402069101. September 14, 2004. View on PubMed.
Progression to androgen-independent LNCaP human prostate tumors: cellular and molecular alterations. Zhou JR, Yu L, Zerbini LF, Libermann TA, Blackburn GL Int J Cancer. 110(6):800-6. doi: 10.1002/ijc.20206. July 20, 2004. View on PubMed.
Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Hong YK, Foreman K, Shin JW, Hirakawa S, Curry CL, Sage DR, Libermann T, Dezube BJ, Fingeroth JD, Detmar M Nat Genet. 36(7):683-5. doi: 10.1038/ng1383. June 27, 2004. View on PubMed.
Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. Wang H, Fang R, Cho JY, Libermann TA, Oettgen P J Biol Chem. 279(24):25241-50. doi: 10.1074/jbc.M401356200. June 11, 2004. View on PubMed.
Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. Cho JY, Akbarali Y, Zerbini LF, Gu X, Boltax J, Wang Y, Oettgen P, Zhang DE, Libermann TA J Biol Chem. 279(19):19512-22. doi: 10.1074/jbc.M309074200. May 7, 2004. View on PubMed.
ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. Brown C, Gaspar J, Pettit A, Lee R, Gu X, Wang H, Manning C and 6 others J Biol Chem. 279(13):12794-803. doi: 10.1074/jbc.M308593200. March 26, 2004. View on PubMed.
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Akiyama M, Hideshima T and 8 others Cancer Cell. 5(3):221-30. March 2004. View on PubMed.
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications. Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Hideshima T, Akiyama M and 9 others Proc Natl Acad Sci U S A. 101(2):540-5. doi: 10.1073/pnas.2536759100. January 13, 2004. View on PubMed.
Analysis and robot pipelined automation for SELDI-TOF mass spectrometry. Alterovitz G, Aivado M, Spentzos D, Libermann TA, Ramoni M, Kohane IS Conf Proc IEEE Eng Med Biol Soc. 4:3068-71. doi: 10.1109/IEMBS.2004.1403867. 2004. View on PubMed.
Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repressio Gupta M, Sueblinvong V, Raman J, Jeevanandam V, Gupta MP J Biol Chem. 278(45):44935-48. doi: 10.1074/jbc.M307696200. November 7, 2003. View on PubMed.
Gene expression profile after cardiopulmonary bypass and cardioplegic arrest. Ruel M, Bianchi C, Khan TA, Xu S, Liddicoat JR, Voisine P, Araujo E and 4 others J Thorac Cardiovasc Surg. 126(5):1521-30. doi: 10.1016/S0022. November 2003. View on PubMed.
Comment on " 'Stemness': transcriptional profiling of embryonic and adult stem cells" and "a stem cell molecular signature". Fortunel NO, Otu HH, Ng HH, Chen J, Mu X, Chevassut T, Li X and 9 others Science. 302(5644):393; author reply 393. doi: 10.1126/science.1086384. October 17, 2003. View on PubMed.
Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1. Grall F, Gu X, Tan L, Cho JY, Inan MS, Pettit AR, Thamrongsak U and 10 others Arthritis Rheum. 48(5):1249-60. doi: 10.1002/art.10942. May 2003. View on PubMed.
Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer. Zerbini LF, Wang Y, Cho JY, Libermann TA Cancer Res. 63(9):2206-15. May 1, 2003. View on PubMed.
The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Mitsiades N, Mitsiades CS, Richardson PG, Poulaki V, Tai YT, Chauhan D, Fanourakis G and 8 others Blood. 101(6):2377-80. doi: 10.1182/blood-2002-06-1768. March 15, 2003. View on PubMed.
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA and 6 others J Clin Invest. 111(5):649-58. doi: 10.1172/JCI17189. March 2003. View on PubMed.
Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells. Hirakawa S, Hong YK, Harvey N, Schacht V, Matsuda K, Libermann T, Detmar M Am J Pathol. 162(2):575-86. doi: 10.1016/S0002-9440(10)63851-5. February 2003. View on PubMed.
ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells. Kwon JH, Keates S, Simeonidis S, Grall F, Libermann TA, Keates AC J Biol Chem. 278(2):875-84. doi: 10.1074/jbc.M208241200. January 10, 2003. View on PubMed.
Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung. Silverman ES, Baron RM, Palmer LJ, Le L, Hallock A, Subramaniam V, Riese RJ and 8 others Am J Respir Cell Mol Biol. 27(6):697-704. doi: 10.1165/rcmb.2002-0011OC. December 2002. View on PubMed.
Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Mitsiades N, Mitsiades CS, Poulaki V, Chauhan D, Fanourakis G, Gu X, Bailey C and 7 others Proc Natl Acad Sci U S A. 99(22):14374-9. doi: 10.1073/pnas.202445099. October 29, 2002. View on PubMed.
Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer. Muotri AR, Marchetto MC, Zerbini LF, Libermann TA, Ventura AM, Sarasin A, Menck CF Hum Gene Ther. 13(15):1833-44. doi: 10.1089/104303402760372936. October 10, 2002. View on PubMed.
DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma. Baron RM, Palmer LJ, Tantisira K, Gabriel S, Sonna LA, Le L, Hallock A and 4 others Am J Respir Crit Care Med. 166(7):927-32. doi: 10.1164/rccm.200201-048OC. October 1, 2002. View on PubMed.
Insertion of an exogenous domain in the adenovirus type 2 fiber globular region. Zerbini LF, Libermann TA, Ventura AM Biochem Biophys Res Commun. 296(4):897-903. August 30, 2002. View on PubMed.
Opposing functions of the Ets factors NERF and ELF-1 during chicken blood vessel development. Gaspar J, Thai S, Voland C, Dube A, Libermann TA, Iruela-Arispe ML, Oettgen P Arterioscler Thromb Vasc Biol. 22(7):1106-12. July 1, 2002. View on PubMed.
Adenovirus vector-induced inflammation: capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B. Bowen GP, Borgland SL, Lam M, Libermann TA, Wong NC, Muruve DA Hum Gene Ther. 13(3):367-79. doi: 10.1089/10430340252792503. February 10, 2002. View on PubMed.
CHIP TUNER: a web tool for evidence-based noise reduction in gene discovery. Tsien CL, Libermann TA, Gu X, Kho A, Kohane IS Proc AMIA Symp. :810-4. 2002. View on PubMed.
Epstein-Barr Virus and its glycoprotein-350 upregulate IL-6 in human B-lymphocytes via CD21, involving activation of NF-kappaB and different signaling pathways. D'Addario M, Libermann TA, Xu J, Ahmad A, Menezes J J Mol Biol. 308(3):501-14. doi: 10.1006/jmbi.2001.4589. May 4, 2001. View on PubMed.
Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6. Gu X, Shin BH, Akbarali Y, Weiss A, Boltax J, Oettgen P, Libermann TA J Biol Chem. 276(12):9421-36. doi: 10.1074/jbc.M010070200. March 23, 2001. View on PubMed.
Elf-1 is a transcriptional regulator of the Tie2 gene during vascular development. Dube A, Thai S, Gaspar J, Rudders S, Libermann TA, Iruela-Arispe L, Oettgen P Circ Res. 88(2):237-44. February 2, 2001. View on PubMed.
ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene. Rudders S, Gaspar J, Madore R, Voland C, Grall F, Patel A, Pellacani A, Perrella MA, Libermann TA, Oettgen P J Biol Chem. 276(5):3302-9. doi: 10.1074/jbc.M006507200. February 2, 2001. View on PubMed.
On reporting fold differences. Tsien CL, Libermann TA, Gu X, Kohane IS Pac Symp Biocomput. :496-507. 2001. View on PubMed.
Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB. Borgland SL, Bowen GP, Wong NC, Libermann TA, Muruve DA J Virol. 74(9):3941-7. May 2000. View on PubMed.
Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation. Brembeck FH, Opitz OG, Libermann TA, Rustgi AK Oncogene. 19(15):1941-9. doi: 10.1038/sj.onc.1203441. April 6, 2000. View on PubMed.
ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. Kas K, Finger E, Grall F, Gu X, Akbarali Y, Boltax J, Weiss A, Oettgen P, Kapeller R, Libermann TA J Biol Chem. 275(4):2986-98. January 28, 2000. View on PubMed.
PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression. Oettgen P, Finger E, Sun Z, Akbarali Y, Thamrongsak U, Boltax J, Grall F and 8 others J Biol Chem. 275(2):1216-25. January 14, 2000. View on PubMed.
Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes. Oettgen P, Kas K, Dube A, Gu X, Grall F, Thamrongsak U, Akbarali Y and 6 others J Biol Chem. 274(41):29439-52. October 8, 1999. View on PubMed.
Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear factor-kappaB. Schwaninger M, Sallmann S, Petersen N, Schneider A, Prinz S, Libermann TA, Spranger M J Neurochem. 73(4):1461-6. October 1999. View on PubMed.
AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter. Libermann TA, Pan Z, Akbarali Y, Hetherington CJ, Boltax J, Yergeau DA, Zhang DE J Biol Chem. 274(35):24671-6. August 27, 1999. View on PubMed.
Role of the Ets transcription factors in the regulation of the vascular-specific Tie2 gene. Dube A, Akbarali Y, Sato TN, Libermann TA, Oettgen P Circ Res. 84(10):1177-85. May 28, 1999. View on PubMed.
Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo. Muruve DA, Barnes MJ, Stillman IE, Libermann TA Hum Gene Ther. 10(6):965-76. doi: 10.1089/10430349950018364. April 10, 1999. View on PubMed.
Genomic organization of the human ELF3 (ESE-1/ESX) gene, a member of the Ets transcription factor family, and identification of a functional promoter. Oettgen P, Barcinski M, Boltax J, Stolt P, Akbarali Y, Libermann TA Genomics. 55(3):358-62. doi: 10.1006/geno.1998.5681. February 1, 1999. View on PubMed.
Tissue-restricted expression of the cardiac alpha-myosin heavy chain gene is controlled by a downstream repressor element containing a palindrome of two ets-binding sites. Gupta M, Zak R, Libermann TA, Gupta MP Mol Cell Biol. 18(12):7243-58. December 1998. View on PubMed.
Cloning and characterization of GETS-1, a goldfish Ets family member that functions as a transcriptional repressor in muscle. Goldman D, Sapru MK, Stewart S, Plotkin J, Libermann TA, Wasylyk B, Guan K Biochem J. 335 ( Pt 2):267-75. October 15, 1998. View on PubMed.
Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response. Sata M, Perlman H, Muruve DA, Silver M, Ikebe M, Libermann TA, Oettgen P, Walsh K Proc Natl Acad Sci U S A. 95(3):1213-7. February 3, 1998. View on PubMed.
Parathyroid hormone (1-34)-mediated interleukin-6 induction. Onyia JE, Libermann TA, Bidwell J, Arnold D, Tu Y, McClelland P, Hock JM J Cell Biochem. 67(2):265-74. November 1, 1997. View on PubMed.
The novel epithelial-specific Ets transcription factor gene ESX maps to human chromosome 1q32.1. Oettgen P, Carter KC, Augustus M, Barcinski M, Boltax J, Kunsch C, Libermann TA Genomics. 45(2):456-7. doi: 10.1006/geno.1997.4974. October 15, 1997. View on PubMed.
The Novel Epithelial-Specific Ets Transcription Factor Gene ESX Maps to Human Chromosome 1q32.1 Oettgen P, Carter KC, Augustus M, Barcinski M, Boltax J, Kunsch C, Libermann TA Genomics. 445(2):456-7. October 15, 1997. View on PubMed.
Ex vivo adenovirus-mediated gene delivery leads to long-term expression in pancreatic islet transplants. Muruve DA, Manfro RC, Strom TB, Libermann TA Transplantation. 64(3):542-6. August 15, 1997. View on PubMed.
Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family. Oettgen P, Alani RM, Barcinski MA, Brown L, Akbarali Y, Boltax J, Kunsch C, Munger K, Libermann TA Mol Cell Biol. 17(8):4419-33. August 1997. View on PubMed.
Adenovirus-mediated expression of Fas ligand induces hepatic apoptosis after Systemic administration and apoptosis of ex vivo-infected pancreatic islet allografts and isografts. Muruve DA, Nicolson AG, Manfro RC, Strom TB, Sukhatme VP, Libermann TA Hum Gene Ther. 8(8):955-63. doi: 10.1089/hum.1997.8.8-955. May 20, 1997. View on PubMed.
ELF-1 interacts with and transactivates the IgH enhancer pi site. Akbarali Y, Oettgen P, Boltax J, Libermann TA J Biol Chem. 271(42):26007-12. October 18, 1996. View on PubMed.
Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA Mol Cell Biol. 16(9):5091-106. September 1996. View on PubMed.
Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Chauhan D, Uchiyama H, Akbarali Y, Urashima M, Yamamoto K, Libermann TA, Anderson KC Blood. 87(3):1104-12. February 1, 1996. View on PubMed.
Interleukin-6 Gene Expression by Prostaglandins and Cyclic AMP Mediated by Multiple Regulatory Elements. Dendorfer U, Oettgen P, Libermann TA Am J Ther. 2(9):660-665. September 1995. View on PubMed.
Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Dendorfer U, Oettgen P, Libermann TA Mol Cell Biol. 14(7):4443-54. July 1994. View on PubMed.
ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development. Lopez M, Oettgen P, Akbarali Y, Dendorfer U, Libermann TA Mol Cell Biol. 14(5):3292-309. May 1994. View on PubMed.
Coexpression of interleukin-1 beta and interleukin-6 in human brain tumors. Lichtor T, Libermann TA Neurosurgery. 34(4):669-72; discussion 672-3. April 1994. View on PubMed.
Pi, a pre-B-cell-specific enhancer element in the immunoglobulin heavy-chain enhancer. Libermann TA, Baltimore D Mol Cell Biol. 13(10):5957-69. October 1993. View on PubMed.
HSV-1-inducible proteins bind to NF-kappa B-like sites in the HSV-1 genome. Rong BL, Libermann TA, Kogawa K, Ghosh S, Cao LX, Pavan-Langston D, Dunkel EC Virology. 189(2):750-6. August 1992. View on PubMed.
Involvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression. Libermann TA, Lenardo M, Baltimore D Mol Cell Biol. 10(6):3155-62. June 1990. View on PubMed.
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Libermann TA, Baltimore D Mol Cell Biol. 10(5):2327-34. May 1990. View on PubMed.
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines. Nistér M, Libermann TA, Betsholtz C, Pettersson M, Claesson-Welsh L, Heldin CH, Schlessinger J, Westermark B Cancer Res. 48(14):3910-8. July 15, 1988. View on PubMed.
An angiogenic growth factor is expressed in human glioma cells. Libermann TA, Friesel R, Jaye M, Lyall RM, Westermark B, Drohan W, Schmidt A, Maciag T, Schlessinger J EMBO J. 6(6):1627-32. June 1987. View on PubMed.
Structural features of growth factor receptors with oncogenic potential. Chen E, Coussens L, Liao YC, Smith D, Yang-Feng TL, McGrath J, Van Beveren C, Verma IM, Libermann TA, Schlessinger J Biochem Soc Symp. 52:65-82. 1986. View on PubMed.
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Coussens L, Yang-Feng TL, Liao YC, Chen E, Gray A, McGrath J, Seeburg PH, Libermann TA, Schlessinger J, Francke U Science. 230(4730):1132-9. December 6, 1985. View on PubMed.
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J Nature. 313(5998):144-7. January 10, 1985. View on PubMed.
Amplification and overexpression of the EGF receptor gene in primary human glioblastomas. Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J J Cell Sci Suppl. 3:161-72. 1985. View on PubMed.
The carbohydrate specificities of the monoclonal antibodies 29.1, 455 and 3C1B12 to the epidermal growth factor receptor of A431 cells. Gooi HC, Hounsell EF, Lax I, Kris RM, Libermann TA, Schlessinger J, Sato JD, Kawamoto T, Mendelsohn J, Feizi T Biosci Rep. 5(1):83-94. January 1985. View on PubMed.
Antibodies to two defined regions of the transforming protein pp60src interact specifically with the epidermal growth factor receptor kinase system. Lax I, Bar-Eli M, Yarden Y, Libermann TA, Schlessinger J Proc Natl Acad Sci U S A. 81(19):5911-5. October 1984. View on PubMed.
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tam AW, Lee J, Yarden Y, Libermann TA, Schlessinger J Nature. 309(5967):418-25. June 6, 1984. View on PubMed.
Expression of epidermal growth factor receptors in human brain tumors. Libermann TA, Razon N, Bartal AD, Yarden Y, Schlessinger J, Soreq H Cancer Res. 44(2):753-60. February 1984. View on PubMed.
Monoclonal antibody reactive with the human epidermal-growth-factor receptor recognizes the blood-group-A antigen. Gooi HC, Schlessinger J, Lax I, Yarden Y, Libermann TA, Feizi T Biosci Rep. 3(11):1045-52. November 1983. View on PubMed.
Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH3). Hapgood J, Libermann TA, Lax I, Yarden Y, Schreiber AB, Naor Z, Schlessinger J Proc Natl Acad Sci U S A. 80(21):6451-5. November 1983. View on PubMed.
Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies. Schreiber AB, Libermann TA, Lax I, Yarden Y, Schlessinger J J Biol Chem. 258(2):846-53. January 25, 1983. View on PubMed.
Regulation of cell proliferation by epidermal growth factor. Schlessinger J, Schreiber AB, Levi A, Lax I, Libermann T, Yarden Y CRC Crit Rev Biochem. 14(2):93-111. 1983. View on PubMed.
Intracellular and extracellular components involved in the formation of ventral surfaces of fibroblasts. Birchmeier W, Libermann TA, Imhof BA, Kreis TE Cold Spring Harb Symp Quant Biol. 46 Pt 2:755-67. 1982. View on PubMed.
Molecular steps in the action and regulation of epidermal growth factor: a cellular mitogen. Schlessinger J, Schreiber AB, Lax I, Yashuv-Gan Y, Libermann TA, Hillman GM, Levi A, Yarden Y Prog Clin Biol Res. 91:359-72. 1982. View on PubMed.
Phosphorylation and dephosphorylation of spectrin from human erythrocyte ghosts under physiological conditions: autocatalysis rather than reaction with separate kinase and phosphatase. Imhof BA, Acha-Orbea HJ, Libermann TA, Reber BF, Lanz JH, Winterhalter KH, Birchmeier W Proc Natl Acad Sci U S A. 77(6):3264-8. June 1980. View on PubMed.
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