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Sebastien Vigneau

Position - Company  
Graduate Student - Institut Pasteur

Functional study of the X-chromosome inactivation process using targeted deletions within the mouse X-chromosome inactivation center.

Supervised by Dr. Philippe Clerc
Mouse Molecular Genetics unit led by Pr. Philip Avner
Pasteur Institute, Paris, France.
Website: http://www.pasteur.fr/recherche/unites/Gmm/index-en.html

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Sep 2003 - Sep 2007
Trainee - Ecole Normale Supérieure

Characterization of the identity and the migration of Dbx1 expressing cells in the mouse telencephalon.

Supervised by Dr. Alessandra Pierani
Brain Regionalization team led by Dr. Marion Wassef
Ecole Normale Supérieure, Paris, France.
Website: http://www.biologie.ens.fr/desnrnv/

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Sep 2002 - Sep 2003
Trainee - Centre de Biologie du Développement

Study of the msxB regulatory elements in zebrafish.

Supervised by Dr. Patrick Blader
Control of Neuronal Identity team led by Dr. Patrick Blader
Centre de Biologie du Développement, Toulouse, France.
Website: http://www-cbd.ups-tlse.fr/cbd/equipes/equipe.php?lang=Fr&Equipe=blader

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Feb 2002 - Jun 2002
Trainee - Biosentec

Developing an ethanol enzymatic biosensor.

Biosentec, Toulouse, France.
Website: http://www.biosentec.fr

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Jul 2001 - Aug 2001
Trainee - INRA

Developing a functional complementation system in Medicago truncatula with the aim of performing positional cloning of the DMI1 gene.

Supervised by Dr. Jean-Michel Ané
Symbiotics Signals team led by Jean Dénarié
Institut National de Recherche Agronomique, Toulouse, France.
Website:
http://compact.jouy.inra.fr/compact/CONSULTER/INTER/externe/equipes/ecrans/441_5

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Feb 2001 - Jun 2001
Trainee - CerCo-CNRS

Modeling vision evoked potentials as measured by electroencephalograms.

Supervised by Margot Taylor
Margot Taylor’s team
CerCo-CNRS, Toulouse, France.
Website: http://www.cerco.ups-tlse.fr/fr_vers/cerco_eng/index.php?url=presentation.htm

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Jul 2000 - Aug 2000
Trainee - THALES ALENIA SPACE

Modeling a satellite element using finite element analysis.

Calculation service
Thales Alenia Space, Toulouse, France.
Website: http://www.thalesgroup.com/Markets/Space/Home/

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Jul 1998 - Jul 1998
Teaching Assistant - University of Pennsylvania School of Arts and Sciences

BIOL425 laboratory designed by John Wagner: "Exploring the relationship between epigenetics and organismal longevity, using yeast as a model system".
Students are taught how to conduct independent research, through tackling an open research question during the course. Techniques used include reverse-genetic screening of histone mutations, microarray analysis, Western-blot and gene over-expression.

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Jan 2012 - Present
Vice-President for Information Technologies - Penn Biotech Group

February 2009 - May 2009: team member, performed a market study for a microarray analysis software.
September 2009 - November 2009: team member, performed a market study for a behavioral therapy software.
July 2009 - June 2010: director of communications and information technologies, installed and configured an intranet system for project management based on Open Atrium/Drupal.
July 2010 - present: vice-president for information technologies, managing an intranet system for project management based on Open Atrium/Drupal.

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Feb 2009 - Present
Postdoctoral researcher - Perelman School of Medicine University of Pennsylvania

Project 1: Investigating the regulation and activity of the DNA-binding protein CTCF.

Project 2: Investigating the epigenetic control of MeCP2 in the brain; establishing a screen to identify MeCP2 gene activators for the treatment of Rett syndrome.

Supervised by Marisa Bartolomei
Marisa Bartolomei's laboratory
University of Pennsylvania School of Medicine, Philadelphia, USA
Website: http://www.med.upenn.edu/

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Mar 2008 - Present
Degree - University  
Certificate, Bioinformatics - Conservatoire National des Arts et Métiers

Basic programming in Unix shell, html, scheme, java.
Algorithmic for bioinformatics.
Biostatistics.
Sequences and protein structure analysis.

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2004 - 2007
PhD, Biology - Université Pierre et Marie Curie

Functional study of X-chromosome inactivation process using targeted deletions within the mouse X-chromosome inactivation center.

supervised by Dr. Philippe Clerc
in the Mouse Molecular Genetics unit directed by Pr. Philip Avner
Institut Pasteur, Paris, France.
Website: http://www.pasteur.fr/recherche/unites/Gmm/index-en.html

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2003 - 2007
DEA, Developmental biology - Université Pierre et Marie Curie

Master of Science (« Diplôme d’Etudes Approfondies ») in Molecular and Cellular Biology of Development.

Practical classes in embryology (mouse, chicken, frog, zebrafish, drosophila, c.elegans, starfish and sea-urchin)

Seminars on embryonic polarity, organizers and induction in embryos, mouse development, myogenesis, chromatin, EvoDevo, new methodologies in developmental biology.

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2002 - 2003
Maîtrise, Biology - Université Paul Sabatier (Toulouse III)

Bachelor of Science (« Maîtrise ») in Cellular and Developmental Biology

Cellular and molecular biology, genetics, developmental biology, neurobiology, bioinformatics.

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2001 - 2002
Licence, Biology - Université Paul Sabatier (Toulouse III)

Cellular and molecular biology, genetics, biochemistry, biophysics, developmental biology, animal physiology.

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2000 - 2001
DEUG, Biology - Université Paul Sabatier (Toulouse III) 1998 - 2000
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