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M. Andrea Azcarate Peril

Associate Professor of Medicine - University of North Carolina at Chapel Hill

Position - Company  
ASSISTANT PROFESSOR - Microbiome Core Facility University of North Carolina at Chapel Hill School of Medicine Nov 2008 - Present
Associate Professor of Medicine - University of North Carolina at Chapel Hill Feb 2018 - Present
Adjunt Assistant Professor of Plant and Microbial Biology - North Carolina State University Jan 2018 - Present
Adjunt Assistant Professor of Nutrition - University of North Carolina at Chapel Hill Dec 2017 - Present
Director, Microbiome Core Facility - University of North Carolina at Chapel Hill

The human body is the home to approximately 10,000,000,000 bacterial cells that inhabit our gastrointestinal tract, mouth, urogenital tract, and our skin. Most of these bacteria are uncultivable, which meant in the past that researchers were unable to study and characterize them. The development of metagenomic technologies allow us today to examine microbial communities through culture independent techniques, of which the most used are next-generation sequencing methods.

The UNC Microbiome Core Facility was established to provide technical and research support to study community structure and function of host-associated microbial populations.

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Nov 2009 - Present
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Publication Info
Comparative phenotypic analysis and genome sequence of Clostridium beijerinckii SA-1, an offspring of NCIMB 8052. Sandoval-Espinola WJ, Makwana ST, Chinn MS, Thon MR, Azcárate-Peril MA, Bruno-Bárcena JM Microbiology. :. doi: 10.1099/mic.0.069534-0. September 25, 2013. View on PubMed.
Fusobacterium spp. and colorectal cancer: cause or consequence? Keku TO, McCoy AN, Azcarate-Peril AM Trends Microbiol. :. doi: 10.1016/j.tim.2013.08.004. September 9, 2013. View on PubMed.
Diet Complexity and Estrogen Receptor β Status Affect the Composition of the Murine Intestinal Microbiota. Menon R, Watson SE, Thomas LN, Allred CD, Dabney A, Azcarate-Peril MA, Sturino JM Appl Environ Microbiol. 79(18):5763-73. doi: 10.1128/AEM.01182-13. September 2013. View on PubMed.
Impact of ileocecal resection and concomitant antibiotics on the microbiome of the murine jejunum and colon. Devine AA, Gonzalez A, Speck KE, Knight R, Helmrath M, Lund PK, Azcarate-Peril MA PLoS One. 8(8):e73140. doi: 10.1371/journal.pone.0073140. August 27, 2013. View on PubMed.
Heterologous expression of a bioactive β-hexosyltransferase, an enzyme producer of prebiotics, from Sporobolomyces singularis. Dagher SF, Azcarate-Peril MA, Bruno-Bárcena JM Appl Environ Microbiol. 79(4):1241-9. doi: 10.1128/AEM.03491-12. February 2013. View on PubMed.
Fusobacterium is associated with colorectal adenomas. McCoy AN, Araújo-Pérez F, Azcárate-Peril A, Yeh JJ, Sandler RS, Keku TO PLoS One. 8(1):e53653. doi: 10.1371/journal.pone.0053653. January 15, 2013. View on PubMed.
The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer? Azcárate-Peril MA, Sikes M, Bruno-Bárcena JM Am J Physiol Gastrointest Liver Physiol. 301(3):G401-24. doi: 10.1152/ajpgi.00110.2011. September 2011. View on PubMed.
Acute necrotizing enterocolitis of preterm piglets is characterized by dysbiosis of ileal mucosa-associated bacteria. Azcarate-Peril MA, Foster DM, Cadenas MB, Stone MR, Jacobi SK, Stauffer SH, Pease A, Gookin JL Gut Microbes. 2(4):234-43. doi: 10.4161/gmic.2.4.16332. August 2011. View on PubMed.
Construction of vectors for inducible and constitutive gene expression in Lactobacillus. Duong T, Miller MJ, Barrangou R, Azcarate-Peril MA, Klaenhammer TR Microb Biotechnol. 4(3):357-67. doi: 10.1111/j.1751-7915.2010.00200.x. May 2011. View on PubMed.
Role of antioxidant enzymes in bacterial resistance to organic acids. Bruno-Bárcena JM, Azcárate-Peril MA, Hassan HM Appl Environ Microbiol. 76(9):2747-53. doi: 10.1128/AEM.02718-09. May 2010. View on PubMed.
Role of autoinducer-2 on the adhesion ability of Lactobacillus acidophilus. Buck BL, Azcarate-Peril MA, Klaenhammer TR J Appl Microbiol. 107(1):269-79. doi: 10.1111/j.1365-2672.2009.04204.x. July 2009. View on PubMed.
Development and application of a upp-based counterselective gene replacement system for the study of the S-layer protein SlpX of Lactobacillus acidophilus NCFM. Goh YJ, Azcárate-Peril MA, O'Flaherty S, Durmaz E, Valence F, Jardin J, Lortal S, Klaenhammer TR Appl Environ Microbiol. 75(10):3093-105. doi: 10.1128/AEM.02502-08. May 2009. View on PubMed.
Temporal gene expression and probiotic attributes of Lactobacillus acidophilus during growth in milk. Azcarate-Peril MA, Tallon R, Klaenhammer TR J Dairy Sci. 92(3):870-86. doi: 10.3168/jds.2008-1457. March 2009. View on PubMed.
Genome sequence and characteristics of Lrm1, a prophage from industrial Lactobacillus rhamnosus strain M1. Durmaz E, Miller MJ, Azcarate-Peril MA, Toon SP, Klaenhammer TR Appl Environ Microbiol. 74(15):4601-9. doi: 10.1128/AEM.00010-08. August 2008. View on PubMed.
Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals the molecular basis of an autochthonous intestinal organism. Azcarate-Peril MA, Altermann E, Goh YJ, Tallon R, Sanozky-Dawes RB, Pfeiler EA, O'Flaherty S and 6 others Appl Environ Microbiol. 74(15):4610-25. doi: 10.1128/AEM.00054-08. August 2008. View on PubMed.
Characterization of a novel bile-inducible operon encoding a two-component regulatory system in Lactobacillus acidophilus. Pfeiler EA, Azcarate-Peril MA, Klaenhammer TR J Bacteriol. 189(13):4624-34. doi: 10.1128/JB.00337-07. July 2007. View on PubMed.
Influence of the dairy environment on gene expression and substrate utilization in lactic acid bacteria. Klaenhammer TR, Azcarate-Peril MA, Altermann E, Barrangou R J Nutr. 137(3 Suppl 2):748S-50S. March 2007. View on PubMed.
Global analysis of carbohydrate utilization by Lactobacillus acidophilus using cDNA microarrays. Barrangou R, Azcarate-Peril MA, Duong T, Conners SB, Kelly RM, Klaenhammer TR Proc Natl Acad Sci U S A. 103(10):3816-21. doi: 10.1073/pnas.0511287103. March 7, 2006. View on PubMed.
Transcriptional and functional analysis of oxalyl-coenzyme A (CoA) decarboxylase and formyl-CoA transferase genes from Lactobacillus acidophilus. Azcarate-Peril MA, Bruno-Bárcena JM, Hassan HM, Klaenhammer TR Appl Environ Microbiol. 72(3):1891-9. doi: 10.1128/AEM.72.3.1891-1899.2006. March 2006. View on PubMed.
Microarray analysis of a two-component regulatory system involved in acid resistance and proteolytic activity in Lactobacillus acidophilus. Azcarate-Peril MA, McAuliffe O, Altermann E, Lick S, Russell WM, Klaenhammer TR Appl Environ Microbiol. 71(10):5794-804. doi: 10.1128/AEM.71.10.5794-5804.2005. October 2005. View on PubMed.
Genomic features of lactic acid bacteria effecting bioprocessing and health. Klaenhammer TR, Barrangou R, Buck BL, Azcarate-Peril MA, Altermann E FEMS Microbiol Rev. 29(3):393-409. doi: 10.1016/j.femsre.2005.04.007. August 2005. View on PubMed.
Marker-free chromosomal integration of the manganese superoxide dismutase gene (sodA) from Streptococcus thermophilus into Lactobacillus gasseri. Bruno-Bárcena JM, Azcárate-Peril MA, Klaenhammer TR, Hassan HM FEMS Microbiol Lett. 246(1):91-101. doi: 10.1016/j.femsle.2005.03.044. May 1, 2005. View on PubMed.
Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Altermann E, Russell WM, Azcarate-Peril MA, Barrangou R, Buck BL, McAuliffe O, Souther N and 7 others Proc Natl Acad Sci U S A. 102(11):3906-12. doi: 10.1073/pnas.0409188102. March 15, 2005. View on PubMed.
Identification and inactivation of genetic loci involved with Lactobacillus acidophilus acid tolerance. Azcarate-Peril MA, Altermann E, Hoover-Fitzula RL, Cano RJ, Klaenhammer TR Appl Environ Microbiol. 70(9):5315-22. doi: 10.1128/AEM.70.9.5315-5322.2004. September 2004. View on PubMed.
Sequence analysis of pLBB1, a cryptic plasmid from Lactobacillus delbrueckii subsp. bulgaricus. Azcárate-Peril MA, Raya RR Can J Microbiol. 48(2):105-12. February 2002. View on PubMed.
Deoxyribonuclease activities in Lactobacillus delbrueckii. Azcárate Peril MA, Auad L, Raya RR Microbiol Res. 155(2):101-6. doi: 10.1016/S0944-5013(00)80044-0. July 2000. View on PubMed.
From Jing Xu (Northwestern University) on 2014-06-23 10:42:53 -0400 Nice service. Read more
From Jesse vanWestrienen (Biomeme) on 2014-01-27 12:52:33 -0500 M. Andrea was great to work with. She was extremely accommodating expanding the scope of the pro... Read more
From Desmond Mascarenhas (Protigen) on 2013-01-07 11:58:10 -0500 Great job! Thanks. Read more