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Nadja Grobe

Postdoctoral Research Fellow - Morris lab

Position - Company  
Postdoctoral Research Fellow - Morris lab Wright State University Boonshoft School of Medicine

The balance of the renin angiotensin system in cardiovascular function.

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Jan 2010 - Present
Degree - University  
PhD, Biochemistry - Martin Luther University, Halle, Germany

Dissertation "Biosynthesis of morphine in mammals" with Prof. Dr. Meinhart Zenk

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2006 - 2009
MS, Biochemistry - Martin Luther University, Halle, Germany

Thesis "Characterization of enzymes involved in the biosynthesis of secondary metabolites in plants" with Prof. Dr. Toni M. Kutchan

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2000 - 2005
Publication Info
Mass spectrometry for the molecular imaging of angiotensin metabolism in kidney. Grobe N, Elased KM, Cool DR, Morris M Am J Physiol Endocrinol Metab. 302(8):E1016-24. doi: 10.1152/ajpendo.00515.2011. April 15, 2012. View on PubMed.
Picomolar concentrations of morphine in human urine determined by dansyl derivatization and liquid chromatography-mass spectrometry. Lamshöft M, Grobe N, Spiteller M J Chromatogr B Analyt Technol Biomed Life Sci. 879(13-14):933-7. doi: 10.1016/j.jchromb.2011.02.044. April 15, 2011. View on PubMed.
An (R)-specific N-methyltransferase involved in human morphine biosynthesis. Grobe N, Ren X, Kutchan TM, Zenk MH Arch Biochem Biophys. 506(1):42-7. doi: 10.1016/j.abb.2010.11.010. February 1, 2011. View on PubMed.
The biosynthesis of papaverine proceeds via (S)-reticuline. Han X, Lamshöft M, Grobe N, Ren X, Fist AJ, Kutchan TM, Spiteller M, Zenk MH Phytochemistry. 71(11-12):1305-12. doi: 10.1016/j.phytochem.2010.04.022. May 20, 2010. View on PubMed.
Urinary excretion of morphine and biosynthetic precursors in mice. Grobe N, Lamshöft M, Orth RG, Dräger B, Kutchan TM, Zenk MH, Spiteller M Proc Natl Acad Sci U S A. 107(18):8147-52. doi: 10.1073/pnas.1003423107. May 4, 2010. View on PubMed.
Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis. Grobe N, Zhang B, Fisinger U, Kutchan TM, Zenk MH, Guengerich FP J Biol Chem. 284(36):24425-31. doi: 10.1074/jbc.M109.011320. September 4, 2009. View on PubMed.
Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone--a Pönisch W, Mitrou PS, Merkle K, Herold M, Assmann M, Wilhelm G, Dachselt K and 15 others J Cancer Res Clin Oncol. 132(4):205-12. doi: 10.1007/s00432-005-0074-4. April 2006. View on PubMed.
Anti-dsDNA antibody subtypes and anti-C1q antibodies: toward a more reliable diagnosis and monitoring of systemic lupus erythematosus and lupus nephritis. Jaekell HP, Trabandt A, Grobe N, Werle E Lupus. 15(6):335-45. doi: 10.1191/0961203306lu2308oa. 2006. View on PubMed.
[Allogeneic blood stem cell transplantation in high-risk patients after conditioning with treosulfan and fludarabine]. Casper J, Wilhelm S, Steiner B, Wolff D, Grobe N, Hähling D, Hartung G and 7 others Dtsch Med Wochenschr. 130(38):2125-9. doi: 10.1055/s-2005-916351. September 23, 2005. View on PubMed.
Autoantibodies to prothrombin and phosphatidylserine/prothrombin-complexes: do they contribute to the serodiagnosis of primary and secondary anti-phospholipid syndrome? Jaekel HP, Trabandt A, Schmid D, Grobe N, Müller EW, Ziutelis V, Kaskel-Paul S and 5 others Clin Lab. 50(5-6):295-304. 2004. View on PubMed.
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