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  • Influence of donor microbiota on the severity of experimental graft-versus-host-disease.

    Biol Blood Marrow Transplant. 19(1):164-8. doi: 10.1016/j.bbmt.2012.09.001. January 2013. View on PubMed.
  • Authors

    Tawara I, Liu C, Tamaki H, Toubai T, Sun Y, Evers R, Nieves E, Mathewson N, Nunez G, and Reddy P
  • Abstract

    The link between microbial flora and the shaping of immune responses is being increasingly appreciated, and recent data have uncovered a role for recipient microbiota in the severity of graft-versus-host disease (GVHD). The impact of donor microbiota on T cell-mediated alloresponses and GVHD is not known, however. Using multiple clinically relevant murine models, we analyzed the effect of donor microbiota on the severity of GVHD induced by T cells from specific pathogen-free and germ-free donors, and found that donor microbiota does not alter the expansion or differentiation of alloreactive T cells or the severity of GVHD.

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