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  • Nucleosome mobilization and positioning by ISWI-containing chromatin-remodeling factors.

    J Cell Sci. 114(Pt 14):2561-8. July 2001. View on PubMed.
  • Authors

    Längst G and Becker PB
  • Abstract

    ATP-dependent chromatin-remodeling machines of the SWI/SNF family are involved in many cellular processes in eukaryotic nuclei, such as transcription, replication, repair and recombination. Remodeling factors driven by the ATPase ISWI make up a subgroup of this family that exhibits defined mechanistic and functional characteristics. ISWI-induced nucleosome mobility endows nucleosomal arrays with dynamic properties and recent results suggest that ISWI-type remodelers have diverse functions that range from transcriptional regulation to chromatin assembly and maintenance of chromosome structure.

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