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  • Mitochondrial calcium homeostasis: mechanisms and molecules.

    IUBMB life. 52(3-5):213-9. January 1, 2013. View on PubMed.
  • Authors

    G Vandecasteele, G Szabadkai, and Rosario Rizzuto
  • Abstract

    Despite the early characterisation of Ca2+ fluxes in isolated mitochondria and the ability of this ion to up-regulate dehydrogenases of the Krebs cycle, the low affinity of the organelle uptake pathways was a long-standing obstacle to the recognition of a physiological role for mitochondrial Ca2+ uptake. This review begins with a historical account of the main results that proved the contrary and provides a brief description of mitochondrial Ca2+ signals. Then, it discusses the characteristics of Ca2+ regulation of mitochondrial function. Finally, it summarizes recent discoveries on structural aspects of mitochondrial reticulum and its connections to signalling partners such as the endoplasmic reticulum or the plasma membrane.

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