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  • Involvement of sortase anchoring of cell wall proteins in biofilm formation by Streptococcus mutans.

    Infect Immun. 73(6):3773-7. doi: 10.1128/IAI.73.6.3773-3777.2005. June 2005. View on PubMed.
  • Authors

    Dennis Cvitkovitch (Dental Research Institute), Lévesque CM, Voronejskaia E, Huang YC, Mair RW, and Ellen RP
  • Abstract

    Streptococcus mutans is one of the best-known biofilm-forming organisms associated with humans. We investigated the role of the sortase gene (srtA) in monospecies biofilm formation and observed that inactivation of srtA caused a decrease in biofilm formation. Genes encoding three putative sortase-dependent proteins were also found to be up-regulated in biofilms versus planktonic cells and mutations in these genes resulted in reduced biofilm biomass.

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