Intestinal adaptation is the process that attempts to restore total gut absorption after intestinal resection. In humans, the ileum and the colon can undergo adaptation without the jejunum. However, there is little evidence for the jejunum to undergo adaptation in the absence of the ileum. Here, we report the unusual case of a prepubertal boy who underwent total ileal resection, right hemicolectomy, and jejunostomy after a motor vehicle accident. Despite ileal resection, he showed evidence of successful structural and functional jejunal adaptation.