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  • Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

    Immunol Today. 18(9):450-4. September 1997. View on PubMed.
  • Authors

    Effros RB and Pawelec G
  • Abstract

    Extensive in vitro research on fibroblasts has defined numerous genetic and phenotypic changes associated with replicative senescence. Identification of T-cell replicative senescence as a feature of human immunodeficiency virus (HIV) disease and ageing suggests this phenomenon merits more careful consideration by immunologists, especially with regard to chronic infection, memory and adoptive immunotherapy.

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