This article presents insight into the different types of asymmetrical Class III dentofacial deformities, their diagnoses, and the treatment modalities adopted by orthodontists and maxillofacial surgeons. In diagnosing facial and dental asymmetries, a thorough clinical examination and radiographic survey are necessary to determine the extent of the soft tissue, skeletal, dental, and functional involvement. The management of three cases of asymmetrical Class III dentofacial deformities is described. The optimal esthetic results and functional outcomes in the cases outlined were achieved by vertical and anteroposterior reduction with rotation of the mandible in conjunction with meticulously planned pre- and postsurgical orthodontic treatment. When choosing a surgical technique for correction of the problem, the structures involved in the asymmetry, the magnitude of asymmetry, and the patient's concerns and expectations must be taken into consideration.