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  • Regulation of NF-kB in multiple myeloma: therapeutic implications.

    Clin Adv Hematol Oncol. 2(3):162-6. March 2004. View on PubMed.
  • Authors

    Rena Feinman (Department of Surgery), Siegel DS, and Berenson J
  • Abstract

    The nuclear factor kappa B (NF-kappaB) family of transcription factors plays a major role in inflammation, immune and stress responses, oncogenesis, cell migration, and angiogenesis. Aberrant activation of NF-kappaB has also been shown to contribute to intrinsic and inducible drug resistance in numerous cancers, including multiple myeloma. The expression of NF-kappaB-responsive targets will vary depending on the cellular context and type of inducer. The regulation of NF-kappaB activity occurs at multiple levels involving the IkappaB kinase (IKK) complex, members of the IkappaB family, recruitment of heterologous transcription factors and coactivators by NF-kappaB, and post-translational modifications of p65. This article highlights regulatory mechanisms responsible for constitutive NF-kappaB activation and provides justification for target-based therapy for NF-kappaB in multiple myeloma.

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