This study investigated the effects of varying strength exercises and loading scheme on muscle cross-sectional area (CSA) and maximum strength after 4 strength training loading schemes constant intensity and constant exercise (CICE), constant intensity and varied exercise (CIVE), varied intensity and constant exercise (VICE), varied intensity and varied exercise (VIVE). Forty-nine individuals were allocated into 5 groups CICE, CIVE, VICE, VIVE, and control group (C). Experimental groups underwent twice a week training for 12 weeks. Squat 1 repetition maximum was assessed at baseline and after the training period. Whole quadriceps muscle and its heads CSA were also obtained pretraining and posttraining. The whole quadriceps CSA increased significantly (p ≤ 0.05) in all of the experimental groups from pretest to posttest in both the right and left legs CICE 11.6 and 12.0%; CIVE 11.6 and 12.2%; VICE 9.5 e 9.3%; and VIVE 9.9 and 11.6%, respectively. The CIVE and VIVE groups presented hypertrophy in all of the quadriceps muscle heads (p ≤ 0.05), whereas the CICE and VICE groups did not present hypertrophy in the vastus medialis and rectus femoris (RF), and in the RF muscles, respectively (p > 0.05). The CIVE group had greater strength increments than the other training groups (effect size confidence limit of the difference [ESCLdiff] CICE 1.41-1.56; VICE 2.13-2.28; VIVE 0.59-0.75). Our findings suggest (a) CIVE is more efficient to produce strength gains for physically active individuals; (b) as long as the training intensity reaches an alleged threshold, muscle hypertrophy is similar regardless of the training intensity and exercise variation.