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  • Cancer immunotherapy for prostate cancer.

    Can J Urol. 4(2 Supp 1):79-82. June 1997. View on PubMed.
  • Authors

    Tjoa BA, Erickson SJ, Bowes VA, Salgaller ML, Lodge PA, McLean JG, Ragde H, Kenny GM, Boynton AL, and Murphy GP
  • Abstract

    Our approach to prostate cancer immunotherapy involves two components dendritic cells as antigen-presenting cells; and the antigen used to target T-cell attack, HLA-A0201-associated peptides from prostate specific membrane antigen (PSMA). We have conducted a phase I dose-ranging study in 51 men with advanced prostate cancer, using dendritic cells pulsed with a PSMA peptide. no significant toxicity was observed. In that study, T-cell response was enhanced, with seven men meeting NCPC and PSA criteria for partial response. We are now conducting a phase II study with 67 men, who will receive 6 infusions of dendritic cells that have been pulsed with 2 PSMA peptides, at 6-week intervals. The phase II study design and rationale is described in this paper.

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