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  • HLA and T cell receptor polymorphisms in pauciarticular-onset juvenile rheumatoid arthritis.

    Arthritis Rheum. 34(10):1260-7. October 1991. View on PubMed.
  • Authors

    Nepom BS, Malhotra U, Schwarz DA, Nettles JW, Schaller JG, and Concannon P
  • Abstract

    The immunogenetic basis of pauciarticular-onset juvenile rheumatoid arthritis is unclear. We therefore analyzed the HLA and T cell receptor genes present in a clinically well-defined group of patients. We found that the DR8 haplotype contributes most of the HLA-associated risk, although alleles at other loci contribute independently. A candidate disease-associated T cell receptor polymorphism, in contrast, was not identified in this population. Mechanistic implications of these findings are discussed.

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