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  • Cloning and expression of a human glucagon receptor.

    Biochem Biophys Res Commun. 198(1):328-34. doi: 10.1006/bbrc.1994.1046. January 14, 1994. View on PubMed.
  • Authors

    MacNeil DJ, Occi JL, Hey PJ, Strader CD, and Graziano MP
  • Abstract

    A human glucagon receptor has been cloned from human liver tissue. The 1578-bp cDNA clone encodes a protein of 477 amino acids with 82% identity to the rat glucagon receptor. The predicted secondary structure and homology to known proteins places this receptor within the superfamily of seven transmembrane domain G protein coupled receptors. Transfection of the human glucagon receptor into COS-7 cells confers upon them high affinity binding for [125I] glucagon. In membranes prepared from COS-7 cells transfected with the human glucagon receptor, the binding of [125I] glucagon is inhibited with the rank order of potency glucagon > oxyntomodulin > glucagon-like peptide 1 (7-36) amide > glucagon-like peptide 2 = gastric inhibitory peptide = secretin.

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