Osteoporosis is a clinical manifestation of fracture from weakened bone tissues. Fracture is the result of incompatibility between biomechanical loading forces and material properties of bone tissues. Bone tissues constantly renew themselves and renovate microstructurally in responding to physiopathological changes. This kind of adaptation evolves as human lifestyles progress to modernization and as medicinal therapeutics advance to individualization. Realization of the bone tissues' adaptation broadens the choices for therapeutic approaches and the utilization of combinational treatments for the sake of not only prolonging life span but also improving life quality.